Biomedical subjects

E M Botkina

Publications and source records attributed to E M Botkina.

3 recordsLinked to original sources

PubMed1981

[Structural changes in renal tissue in experimental staphylococcal septicopyemia].

The structure of the kidney tissue in mice with staphylococcal septicopyemia due to intraperitoneal introduction of Staph. aureus in various doses was studied. It was found that the level of acute purulent inflammation in the kidney tissue was different depending on the site of the affection: the purulent component predominated in the cortical layer, while the necrotic component in the medullary layer and papillae. The most gross changes in the glomerular filter developed in the presence of a swarm of staphylococci and deposition of electron-dense material in the basal capillary layers. It is noted that the study on the ultrastructural changes in the kidney tissue makes it possible to use them for estimation of highly active antibacterial agents.

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PubMedDate not supplied

[Electron microscopic studies of experimental staphylococcal infections in mice as chemotherapeutic models].

Study of ultrastructural changes in the brain and renal tissues has shown that both intracerebral and intraperitoneal administration of staphylococcus in low infecting doses leads to the development in the brain and renal tissues of acute purulent inflammation, with a dramatic growth of infectious process and involvement of all parts of the organs under consideration. The presence in the brain tissues and in its meninges of inflammatory pyonecrotic foci might attest to the necrotic purulent encephalomeningitis, whereas the presence in the cortex and renal medullary substance of histiolymphocytic infiltration and foci of necrosis might be evidence of necrotic glomerulonephritis of bacterial etiology.

Animals↗

PubMedDate not supplied

[Electron microscopic study of the antiviral action of bonafton in experimental influenza infection].

Action of bonaphthon on influenza A virus was studied in experimental influenzal pneumonia of mice. Bonaphthon was shown to lower 1.5-2 fold the reproduction of influenza virus in pulmonary tissue as compared with control. It is suggested that the mechanism of bonaphthon action may be due both to the inhibition of the synthesis of virus-specific membrane protein by the cells and to disordered transport of this polypeptide to the cell membranes. Bonaphthon proved to exert the most favorable effect in the course of its preventive administration in the early stages of infection.

Animals↗