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Biomedical subjects

E M Cordasco

Publications and source records attributed to E M Cordasco.

8 recordsLinked to original sources

Pulmonary amyloidoma and hilar adenopathy. Rare manifestations of primary amyloidosis.

Three cases of primary intrathoracic amyloidosis are reported. Two of these three patients initially had localized parenchymal pulmonary amyloid tumors (or pulmonary amyloidomas). The third patient developed bilateral enlargement of the hilar lymph nodes as a manifestation of primary amyloidosis. These rare manifestations of primary amyloidosis are illustrated, and their clinical signifiance is discussed. Amyloidoma should be considered in patients with unexplained pulmonary nodules or enlargement of hilar lymph nodes.

Aged

Air pollution and COPD.

Air pollution referable to increased ambient levels of sulfur dioxide and suspended particulates is associated with increased episodes of acute bronchitis and is also causally related to some cases of chronic bronchitis. Oxidant air pollution is associated with abnormalities of pulmonary function in children and is a major contributory factor in COP, especially bronchitis, in some areas of the United States. The relationship of nitrogen dioxide atmospheric contamination to COPD is still controversial. In our opinion, the epidemiologic studies conducted to date have been inadequate and further elucidation is indicated. Cadmium fumes and compounds have been found to be instrumental in the development of some cases of chronic bronchitis and emphysema in Sweden. This association is unproved in the United States and warrants a thorough clinical and epidemiologic evaluation.

Air Pollutants

Pulmonary rehabilitation of the patient with COPD.

The basic aims in managing COPD are to minimize hypoxia and to improve the ventilation-perfusion relationship. A progressive daily walking exercise program together with pulmonary physiotherapy, creative or occupational therapy, and respiratory therapy to improve bronchial hygiene is advocated. The main benefits of this program, in addition to improved emotional and sociologic status, are increased exercise tolerance, reduced dyspnea (work of breathing), and reduced oxygen requirements.

Bronchodilator Agents

The central venous O2 saturation test in acute pulmonary fat embolism.

1. The central venous oxygen saturation appears to be a reliable method of assessing the prognosis of patients with pulmonary fat embolism. 2. There was an inverse relationship to the A-a gradient and A-V oxygen difference in this group of patients. Further additional hemodynamic studies concomitantly with central venous oxygen saturation are being investigated. 3. The patients with depressed central venous oxygen saturation should be closely observed and diligently treated earlier, with combined respiratory and pharmacological therapy. 4. Such an approach might prevent the development of pulmonary fat embolism in traumatic patients.

Acute Disease