PubMed Health⌕ Search

Biomedical subjects

E M Degtiareva

Publications and source records attributed to E M Degtiareva.

At least 19 recordsLinked to original sources
PubMed1992

[The modern concepts of hereditary nephritis].

The authors describe the results of modern studies into the problems of genetics, clinical picture, prognosis and prospects of the treatment of inherited nephritis. It is assumed that at the basis of inherited nephritis there lies generalized impairment of the basal membranes, which is determined by mutation of X chromosome that codes the structure of the chains of the fourth fraction of collagen. The phenotypic heterogeneity of the disease is accounted for by mutation of different alleles in a solitary locus. The clinical characteristics of inherited nephritis without hypoacusis and Alport's syndrome in inbred and outbred families is provided as are specific features of the disease evolution. The results and efficacy of kidney transplantation in patients with inherited nephritis in the phase of chronic renal failure are discussed.

Biopsy↗
PubMed1991

[Hormonal interactions and glucocorticoid receptors in patients with the nephrotic syndrome].

As many as 27 children aged 6 to 15 years with morphologically verified nephropathies were examined. Four variants of changes in the thyroid status, characteristic of children with different variants of nephrotic syndrome were distinguished: 1) biochemical signs of primary hypothyroidism, 2) biochemical signs of secondary hypothyroidism, 3) low content of T3, 4) dysfunction of the hypophyseal and thyroid system. It is shown that the low level of steroid receptors, thyroid hormones that the low level of steroid receptors, thyroid hormones (T3 and T4) and cortisol is typical of children with the signs of renal dysplasia. It is assumed that superaddition under such conditions of immune glomerulopathy (glomerulonephritis and nephrotic syndrome) gives rise to the resistance to the treatment with glucocorticoids.

Adolescent↗
PubMed1990

[The growth of children and thyroid function in differentiation disorders of renal tissue].

The growth of children and thyroid function were examined in abnormal differentiation of renal tissue. Forty-four children with different varieties of renal dysembryogenesis were examined. Seventy-three children with acquired renal pathology made up a reference group. Children with congenital nephropathies manifested a higher incidence of delayed growth. The majority of patients with renal dysembryogenesis showed the laboratory signs of both primary and secondary hypothyrosis. The role of thyroid hormones in the genesis of delayed growth and development of children afflicted with renal diseases is under discussion.

Adolescent↗
PubMed1989

[Features of thrombophilia in nephrotic syndrome in children].

A comprehensive study was made of the hemostatic system in 25 children with the nephrotic syndrome and combined forms of glomerulonephritis. Hypercoagulation and a number of factors preventing thrombosis formation were revealed, namely the presence of so-called thrombin-resistant blocked fibrinogen, a rise of the total antithrombin potential at the expense of proteins differing from antithrombin III, sufficient reserves of plasminogen, and a moderate increase of fibrin degradation products.

Antithrombin III↗
PubMed1989

[Health status of children born to women with renal pathology].

The children born to mothers suffering from glomerulonephritis, pyelonephritis and hereditary nephritis were followed up for 4-5 and more years. This allowed a conclusion about a considerable rate of the birth of children with pathology of the urinary system organs (USO) and with diseases of other organs which were diagnosed for the first time at the age of 3-10 years as a result of goal-oriented investigations. The groups of the children born to women with renal diseases were marked by a high perinatal lethality studied by means of retrospective questionnaire. As for the structure of the USO diseases, the children manifested the predominance of the disease patterns associated with dysembryogenesis at the organ (anatomic abnormalities), tissue (dysplasia of the renal tissue) and at the cellular levels (metabolic nephropathies). In children born to women with hereditary nephritis, USO pathology was of the same kind and occurred only in the form of hereditary nephritis, which corresponds to the concepts of monogenously inherited pathology. The demonstration during pregnancy of a considerable rate of the environmental effects capable of exerting a damaging action on the embryonal development of children born to women with glomerulo- and pyelonephritis suggests a concomitant genesis of USO diseases in children born to mothers suffering from renal diseases. The authors discuss measures aimed at the prevention or reduction of the incidence of USO pathology in children as well as at the recognition of pathologies in children born to women with renal diseases at the predisease stage.

Child, Preschool↗
PubMed1989

[Course and outcome of nephropathies of structural renal dysembryogenesis].

The authors elucidate the role played by structural renal dysembryogenesis in the development, progress and outcome of nephropathies. Based on an analysis of mainly morphobiopsies of the kidneys in 298 patients aged 2.5 to 15 years a high incidence of renal dysembryogenesis is shown as an independent disease entity and as combined with acquired nephropathies. This provides basis for regarding structural deficiency of the kidneys as predisposing factor to the development of immune or microbial inflammation. The long-term (up to 18 years) observation over children with the most frequently occurring variant of renal dysembryogenesis, hypoplastic dysplasia, made it possible to define the main clinico-laboratory characteristics and outcome of the pathology determined by a high rate of the formation of chronic renal failure.

Adolescent↗
PubMed1988

[Clinico-genetic characteristics of hereditary nephritis in different populations].

Some data are presented on the clinical features of a course of hereditary nephritis in persons of 13 nationalities residing in the central zone of the RSFSR, in Central Asia and East Slovakia (the Czechoslovak Socialist Republic). At least 2 types of hereditary nephritis transmission (the dominant x-chromosome-linked one was more common than the autosomal-dominant one) not differing in their clinical course were revealed. Basing on a study of the clinical features of a course of disease in 123 autobred and 52 inbred families a more severe course of nephritis was observed in children from the inbred families.

Adult↗