Biomedical subjects

E M F Muri

Publications and source records attributed to E M F Muri.

4 recordsLinked to original sources

PubMed2005

Pseudo-peptides derived from isomannide as potential inhibitors of serine proteases.

Hepatitis C, Dengue and West Nile virus are among of the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors.

Animals↗

PubMed2004

N- t-Boc-amino acid esters of isomannide. Potential inhibitors of serine proteases.

Hepatitis C, Dengue and West Nile virus are some of the most important flaviviruses, that share one important serine protease enzyme. Serine proteases are the most studied class of proteolytic enzyme and, in these cases, a primary target for drug discovery. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N- t-Boc amino acid esters derived of isomannide as potential serine proteases inhibitors.

Amino Acids↗

PubMed2004

Anti-Helicobacter pylori agents. An update.

Helicobacter pylori infection is the major causative factor of a number of gastric pathologies. Several classes of compounds have been identified as anti-H. pylori agents. Here we provide a review of anti-H. pylori compounds that have recently appeared in the literature, including the guanidino, antibiotics, acetamide, pyrazole and benzimidazole compounds.

Anti-Bacterial Agents↗

PubMed2002

Hydroxamic acids as pharmacological agents.

A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A(4) hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.

Amidohydrolases↗