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Biomedical subjects

E M Granger

Publications and source records attributed to E M Granger.

5 recordsLinked to original sources
PubMed1994

Role of acoustic striae in hearing: mechanism for enhancement of sound detection in cats.

We report the results of behavioral studies in cats conducted first, to demonstrate the presence of a monaural mechanism for the enhancement of signal to noise; and then to examine the necessity or sufficiency of the acoustic striae for this mechanism. The results show that cats do indeed have a monaural mechanism for enhancing the detection of tones in co-located background noise for noise levels at least as high as 60 dB SPL. The ablation-behavior results show that surgical section of the dorsal (DAS) and most of the intermediate (IAS) striae has no measurable effect on this mechanism. In sharp contrast, even partial section of the trapezoid body results in a profound and permanent deficit and this deficit is not accounted for by hearing loss alone. It is concluded that the ascending and descending fibers in the dorsal and intermediate acoustic striae are neither necessary nor sufficient for enhancing the detection of salient sounds in a noisy environment while the ascending or descending fibers in the ventral acoustic stria are sufficient and probably necessary.

Acoustic Stimulation↗
PubMed1992

Psychoacoustical contribution of each lateral lemniscus.

Although each lateral lemniscus is required for sound localization in its contralateral hemifield, no auditory function is yet known for the neural activity evoked in the lemniscus ipsilateral to a sound source. In an attempt to assess the role played by the ipsilateral lemniscus, monaural cats were tested on an array of psychoacoustical tasks before and after surgical section of one or the other lateral lemniscus. The results show that the lemniscus contralateral to the remaining intact ear is either necessary or sufficient for 24 of the 26 tests administered. However, the lemniscus ipsilateral to the intact ear is both necessary and sufficient (or alternatively, the contralateral lemniscus makes no obvious contribution) to normal thresholds in two of the tasks: detection of low-frequency tones (< 4 kHz) and detection of low-frequency AM modulation. Because of their projections to the ipsilateral inferior colliculus via the ipsilateral lemniscus, the anatomical substrate of these two unusual tasks is probably the fibers from the MSO and possibly, the LSO, ipsilateral to the intact ear.

Acoustic Stimulation↗
PubMed1988

Role of the acoustic striae in hearing: contribution of dorsal and intermediate striae to detection of noises and tones.

1. Behavioral thresholds were obtained from cats, first with only their right ear and right dorsal, intermediate, and ventral acoustic striae (DAS, IAS, and VAS, respectively) intact, and then again with only their right ventral acoustic stria intact. 2. Using usual definitions of "threshold" the loss of the dorsal and intermediate acoustic striae results in no measurable deficit in the detection of noises or tones on a silent background. 3. In sharp contrast, even partial damage of the ventral acoustic stria (i.e., trapezoid body section) results in marked deficits in sound detection. 4. Therefore, the ventral acoustic stria is both necessary and sufficient to maintain normal acoustical sensitivity. 5. However, loss of the dorsal and intermediate striae seems to result in a degradation of reliability in the detection of suprathreshold sounds--perhaps akin to a deficit in listening.

Acoustic Stimulation↗
PubMed1985

Origin of interhemispheric fibers in acallosal opossum (with a comparison to callosal origins in rat).

The neocortical origins of the anterior commissure in the acallosal, marsupial opossum were studied with the horseradish peroxidase (HRP) method. Following complete surgical transection of the anterior commissure, HRP was applied directly to the cut fiber tips. This procedure resulted in very large numbers of vividly labeled cells within the neocortex. The labeled cells were plotted and counted for comparison among cytoarchitectonic areas and among cortical layers. For comparative purposes, the neocortical origins of the corpus callosum are studied with the same procedure in the rat. No cytoarchitectonic area was entirely devoid of labeled cells in either species. The concentration of labeled cells throughout the entire neocortex averaged 25.2 cells/0.05 mm3 in opossum and 31.2 cells/0.05 mm3 in rat. The concentrations of labeled cells were correlated for the eight cytoarchitectonic areas common to the two species, though they were different enough in number to be statistically reliable. The distribution of labeled cells both among and within cytoarchitectonic areas was often more homogeneous in opossum than in rat. Although cortical layer 1 had no labeled cells in either species, the distribution of labeled cells across the remaining cortical layers differed sharply between the two species. In opossum, layer 3 had the most labeled cells (averaging 55% of the total number) while layer 5 had considerably less (averaging 12%). In rat, layer 5 had as many labeled cells as layer 3--both layers averaging 43% of the total number of labeled cells. In both species, striate cortex deviated markedly from other cytoarchitectonic areas. Although both species had very few labeled cells in striate cortex, those that were labeled were invariably supragranular in opossum and infragranular in rat. The similarities and dissimilarities in the topographic distribution of the origins of the two types of interhemispheric fiber systems seem to parallel the degree of cortical (and thalamic) differentiation in the two animals. However, the differences in laminar distribution are much greater and in particular, the small contribution of layer 5 in opossum as opposed to rat may well be functionally significant.

Animals↗