Biomedical subjects

E M Husslein

Publications and source records attributed to E M Husslein.

2 recordsLinked to original sources

PubMed1989

[Diurnal differences in alcohol absorption].

Under standardized conditions five subjects were submitted twice to a dose of alcohol of 1.1 g/kg. This dose was administered once between 7:15 and 7:45 am. and at a different day between 7:15 and 7:45 pm. The blood alcohol concentration curves in the morning and the evening differed significantly in peak and time elapsed until this value was reached. During the morning the peak averaged 32% higher than in the evening. In the morning it was reached after about 60 min and during evening after 110 min. The elimination rate was about the same. These results show that alcohol is significantly faster absorbed into the blood in the morning than during the evening. This could be explained by accelerated transport of uptaken alcohol into the bowels.

Adult↗

PubMed1987

Morphology of the chronic toxicity of busulfan on the islets of Langerhans in the rat.

Male Wistar rats were fed Busulfan dissolved in fat milk at a daily dose of 0.35, 0.89, 1.20 mg/kg body weight for a period of four, eight and twelve weeks. Examination by light microscopy, including immunohistochemistry, and by electron microscopy revealed changes in the pancreatic islets which were dependent on dose and time. First, hyperaemia was demonstrated, then perivascular "inbleedings" were followed by organisation and islet fibrosis with centripetal reduction of the islet cells. This resulted in an almost complete loss of A-cells and a reduction in the number of B-cells. A morphological factor analysis suggested additional analogies to type I - diabetes mellitus, so that for the formal pathogenesis, islet haematoma and immunological events have to be discussed.

Animals↗