[The conditions for decreasing the risk and increasing the efficacy of infusion therapy].
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Biomedical subjects
Publications and source records attributed to E M Levité.
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Jet high-frequency artificial ventilation produces oscillations of some parts of the chest wall, which in its turn transmits oscillations to the lung parenchyma. It results in the mix-up of the gas in the alveolar space, which leads to the increase in the gradient of oxygen concentration on the alveolar membranes, thus, augmenting oxygen saturation of the blood. The effect is the same when oscillation artificial ventilation is performed, owing to the provocation of the oscillations amplified by the resonance in the natural acoustic circuit, formed by the adjacent parts of the chest and lung parenchyma. Derangement of the exudative adhesion to the bronchi epithelial tissue intensifies gas exchange, when the oscillations are generated in the lungs. It facilitates the removal of the exudate and lets the air into the previously obstructed parts of the lungs. Clinical studies confirm the effect of the increase in the blood oxygenation (by average 20%) at the feeding air column by pneumatic oscillations in the range of 65 Hz, when traditional artificial ventilation is performed.
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A new explanation of improved oxygenation during high-frequency jet ventilation has been suggested. The mechanism is based on resonance oscillations generated by oscillation and injection high-frequency jet ventilation and promoting gas penetration into the alveoli, PaO2 elevation in perimembrane layer and O2 concentration gradient increase between the alveolar and convection zones. Alveolar and bronchial fluctuations facilitate their drainage and decrease pulmonary shunting. The suggested mechanism is explained, using facts known from the practical application of high frequency jet ventilation. The advantages of combined volumic-oscillation high-frequency jet ventilation over the jet one are established, except cases of lung ventilation in patients with open bronchus and in patients transmitted to spontaneous respiration after prolonged controlled lung ventilation.
The improvement of combined anesthesia is associated with the improvement of its control. The latter is possible only with continuous administration of anesthetics. 130 procedures of combined anesthesia were performed in patients subject to abdominal and other types of operations. With this in view fentanyl and calipsol were continuously injected, using modified dosators, to patients pretreated with N2O and total curarization. It has been found that with continuous administration adequate analgesia with stable blood pressure can be achieved provided that 1/3-2/3 of the total fentanyl dose is used as a loading dose at the beginning of anesthesia. The maintenance dose does not change considerably blood anesthetic concentration. If required, changes in the concentrations were achieved by additional fentanyl administration, using a dosator for 25-50 mukg. The technique described has advantages over bolus drug injection and continuous drug infusion. The technique may be considered a controlled one.
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