[Current classification of rickets in children (response to the discussion)].
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Biomedical subjects
Publications and source records attributed to E M Luk'ianova.
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Infants afflicted with rickets demonstrate a reduction in the blood content of vitamin K-dependent protein, osteocalcin, most pronounced in disease of medium gravity, in its calcipenic and phosphopenic varieties. It has been established that there is an inverse correlation between osteocalcin content and the level of parathyroid hormone and a direct correlation between osteocalcin content and the concentration of total and ionized calcium and calcitonin in the blood. It is suggested that measurement of blood osteocalcin in children may serve a diagnostic marker of metabolic disorders and mineralization of osseous tissue.
The experience of follow-up and treatment of over 500 pregnant diabetic women and their newborns is summarised. The incidence of severe complications of pregnancy and labour is shown to rise significantly in this condition, the fetal development and neonatal status being impaired. The effects of the genetic factors, hypoxia, ketoacidosis, metabolic and hormonal errors, complicated pregnancy and labour on the perinatal disease development are defined. A comparative evaluation of various diagnostic techniques for early detection of impaired fetal and neonatal status is presented. An effective complex of organizational, therapeutic, preventive, and rehabilitation activities serve to provide for antenatal care and birth of a healthy infant in a diabetic mother.
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