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Biomedical subjects

E M Lumb

Publications and source records attributed to E M Lumb.

9 recordsLinked to original sources
PubMed1984

Disodium cromoglycate relieves symptoms in symptomatic young smokers. A double blind placebo controlled trial.

We have undertaken a double blind placebo controlled study of disodium cromoglycate (DSCG) in 32 symptomatic young smokers. These individuals had regular morning cough and sputum with the sensation of wheeze, but were not asthmatics as determined by the usual criteria. No significant changes were observed in sputum or serum eosinophils, IgE, IgG or IgA, or sputum histamine concentrations following the administration, for 3 weeks, of either DSCG (20 mg) or placebo, thrice daily. However DSCG, but not placebo, was associated with significant improvements in the symptoms of cough (P less than 0.01) and wheezing (P less than 0.025). We suggest that these changes may be due to an effect of DSCG on the irritant receptor mediated reflex response to cigarette smoke rather than the involvement of mast cells.

Adolescent↗
PubMed1981

Mediators of hypersensitivity in the sputum of young, symptomatic cigarette smokers.

We have measured the concentrations of mediators of hypersensitivity in the sputum of twenty-five young, symptomatic cigarette smokers who regularly expectorated and twenty-three matched non-smokers with a respiratory infection. The measurements included sputum and blood eosinophils, IgE, IgG, IgA and IgM and also sputum histamine. We found a significant increase of sputum histamine, and a higher sputum/serum ratio of IgE in smokers when compared to non-smokers. These findings support the view that the bronchial inflammatory response in smokers, as in chronic bronchitis, involves the participation of mediators of hypersensitivity.

Adult↗
PubMed1977

Karyometric changes in human muscle with age.

Human muscle cell growth was studied to investigate the nucleo-cytoplasmic ratio during development and ageing. The mean muscle fibre size, as well as the number and size of myonuclei were estimated in human muscle biopsies from normal individuals whose ages ranged from 1 to 71 years. Changes in muscle fibre size were accompanied by similar changes in nuclear number, the size of which remained the same. This resulted in a constant nucleo-cytoplasmic ratio during the age range studied. The role of the satellite cell in the maintenance of this ratio was discussed.

Adolescent↗
PubMed1976

Muscle nuclear size in neuromuscular disease.

Nuclear size has been estimated in muscle biopsy specimens from seven healthy individuals, eight patients with infantile spinal muscular atrophy (types I and II), and eight patients with Duchenne muscular dystrophy. The results indicate a great increase in nuclear size in Duchenne muscular dystrophy but not in spinal muscular atrophy when compared with controls. The reasons for this finding are discussed in relation to the pathogenesis of these two groups of diseases.

Cell Nucleus↗