Biomedical subjects

E M Martini

Publications and source records attributed to E M Martini.

3 recordsLinked to original sources

PubMed1996

Chromatin assembly coupled to DNA repair: a new role for chromatin assembly factor I.

DNA repair in the eukaryotic cell disrupts local chromatin organization. To investigate whether the resetting of nucleosomal arrays can be linked to the repair process, we developed model systems, with both Xenopus egg extract and human cell extracts, to follow repair and chromatin assembly in parallel on circular DNA templates. Both systems were able to carry out nucleotide excision repair of DNA lesions. We observed that UV-dependent DNA synthesis occurs simultaneously with chromatin assembly, strongly indicating a mechanistic coupling between the two processes. A complementation assay established that chromatin assembly factor I (CAF1) is necessary for this repair associated chromatin formation.

Animals↗

PubMed1973

Changes in isozyme patterns between monokaryons and dikaryons of a bipolar Coprinus.

Proteins and isozymes of several different classes of enzymes in partially purified protein extracts of monokaryons, dikaryons, and monokaryon mixtures of a bipolar Coprinus sp. were separated on polyacrylamide gels by slab electrophoresis. Differences in protein and isozyme spectra were correlated with the operation of the incompatibility factors and with the results of Wang and Raper on Schizophyllum. It was concluded that the shift from monokaryon to dikaryon mediated a major change in the nature, quantity, or distribution of the proteins of this Coprinus sp.

Aminopeptidases↗

PubMedDate not supplied

Using data in disease management. Opportunities and challenges.

Data collection is much talked about and little practiced. HealthPartners has a fully-developed data collection model that has successfully improved the quality and cost of health services, especially in women's health. This discussion of their system points out the complexities of data collections, the need for managed care plan and clinic cooperation and the clear benefits of the approach. Special attention is paid to developing data-based clinical practice guidelines, reminder systems, identification of at-risk patients and development of patient-centered information about physicians.

Community Participation↗