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Biomedical subjects

E M McDougall

Publications and source records attributed to E M McDougall.

At least 19 recordsLinked to original sources

Lower caliceal stone clearance after shock wave lithotripsy or ureteroscopy: the impact of lower pole radiographic anatomy.

PURPOSE: We determine whether there is a significant relationship between the spatial anatomy of the lower pole, as seen on preoperative excretory urography (IVP), and the outcome after shock wave lithotripsy or ureteroscopy for a solitary lower pole caliceal stone 15 mm. or less. MATERIALS AND METHODS: Between January 1992 and June 1996, 34 patients with 15 mm. or less solitary lower pole stone underwent ureteroscopy with intracorporeal lithotripsy (13) or extracorporeal shock wave lithotripsy (ESWL) with a Dornier HM3 lithotriptor (21). On pretreatment IVP lower pole infundibular length and width, infundibulopelvic angle of the stone bearing calix were measured. Stone size and area were determined from an abdominal plain x-ray. A plain x-ray of the kidneys, ureters and bladder was obtained in all patients at a median followup of 12.3 and 8 months in the ureteroscopy and ESWL groups, respectively. RESULTS: After initial therapy the overall stone-free rate was 62 and 52% in the ureteroscopy and ESWL groups, respectively. Stone-free status after ESWL was significantly related to each anatomical measurement. Infundibulopelvic angle 90 degrees or greater, and infundibular length less than 3 cm. and width greater than 5 mm. were each noted to correlate with an improved stone-free rate after ESWL. In contrast, the stone-free rate after ureteroscopy was not statistically significantly impacted by these anatomical features, although a clinical stone-free trend was identified relating to a favorable infundibular length and infundibulopelvic angle. The infundibulopelvic angle was 90 degrees or greater in 4 stone-free patients (12% overall), including 2 who underwent ureteroscopy and 2 who underwent ESWL. On the other hand, in 2 and 4 stone-free patients (18% overall) who underwent ureteroscopy and ESWL, respectively, favorable radiographic features consisted of a short, wide but acutely angulated infundibulum with the infundibulopelvic angle less than 90 degrees, and infundibular length less than 3 cm. and width 5 mm. or greater. In contrast, in 4 and 6 patients (29% overall) who underwent ureteroscopy and ESWL, respectively, all 3 radiographic features were unfavorable with the infundibulopelvic angle less than 90 degrees, and infundibular length greater than 3 cm. and width less than 5 mm. In these cases the stone-free rate was 50 and 17% after ureteroscopy and ESWL, respectively. CONCLUSIONS: The 3 major radiographic features of the lower pole calix (infundibulopelvic angle, and infundibular length and width) can be easily measured on standard IVP using a ruler and protractor. Each factor individually has a statistically significant influence on stone clearance after ESWL. A wide infundibulopelvic angle or short infundibular length and broad infundibular width regardless of infundibulopelvic angle are significant favorable factors for stone clearance following ESWL. Conversely, these factors have a cumulatively negative effect on the stone clearance rate after ESWL when they are all unfavorable. In ureteroscopy spatial anatomy has less of a role in regard to stone clearance but it may have a negative impact when there is uniformly unfavorable anatomy.

Adult

Laparoscopic creation of a catheterizable cutaneous ureterovesicostomy.

Nephrectomy and creation of a cutaneous ureterovesicostomy for intermittent catheterization of the bladder traditionally requires two surgical procedures performed through separate incisions. Herein we report completion of these procedures using a transperitoneal laparoscopic approach, with the ureterovesicostomy stoma created at one of the laparoscopic working ports. The clinical course was remarkable for a shortened postoperative hospitalization (48 hours) with minimal incisional pain, and an excellent long-term result with complete bladder emptying and resolution of urinary infections. Laparoscopic application of the Mitrofanoff principle for creation of a catheterizable cutaneous ureterovesicostomy combines the advantages of both, allowing optimal preservation of ureteral vascularity, minimal morbidity, and efficient bladder evacuation.

Adolescent

Endourologic management of ureterosigmoidostomy anastomotic stricture.

A 47-year-old woman presented with a stricture of a ureterosigmoid anastomosis. After through-and-through access had been established from a nephrostomy tract to the anus, an Acucise cutting balloon catheter was positioned retrograde and used to incise the strictured area. Twelve months postoperatively, the patient is doing well. Monitoring for colon adenocarcinoma continues.

Anastomosis, Surgical

Recent advances in laparoscopic partial nephrectomy: comparative study of electrosurgical snare electrode and ultrasound dissection.

Although technically feasible, laparoscopic partial nephrectomy (LPN) using conventional instrumentation presents the intraoperative challenge of hemostasis, creating a flush (i.e., precise guillotine) incision, and closure of the collecting system. In an effort to resolve these technical problems, we used a unique electrosurgical snare electrode (ESE) in combination with an ERBE electrosurgical generator and compared its effectiveness with that of two ultrasonic dissectors (Cavitron Ultrasonic Surgical Aspirator [CUSA] and harmonic scalpel [HS]) in performing LPN. Twelve female minipigs underwent right lower-pole LPN using one of the aforementioned modalities. Six weeks later, in the same animals, a left lower-pole LPN was performed using the same device, thereby providing an acute and chronic renal remnant to examine. The animals were harvested, and transverse and perpendicular histologic sections were prepared of the cut surface of each specimen. The weights of the LPN specimens and the remaining kidney were also recorded. The time required for partial nephrectomy, degree of hemostasis (i.e., blood loss), ease of excising the targeted tissue, changes in renal function, tissue reactivity, and depth of damage to the surface of the remaining renal parenchyma were measured for each device. All 12 procedures were successful using the ultrasonic dissection, and 11 procedures were successful using the ESE. The ESE was significantly faster than the two forms of ultrasonic dissection (p < 0.0001) and produced less intraoperative bleeding (P = 0.002). Both forms of ultrasonic energy produced significantly deeper parenchymal injury in the acute surgical specimen (P = 0.03) and more parenchymal fibrosis and chronic inflammation in the chronic surgical specimens (P = 0.007) than the ESE. None of the animals exhibited any extravasation from the incised collecting system when studied by retrograde pyelography 6 weeks postoperatively at the time of left LPN and harvest. The function of the renal remnant was consistent with the size of the partial nephrectomy specimen. No hypertension developed in any of the study animals. Our results using a unique electrosurgical snare probe show it to have potential advantages as a rapid, hemostatic method for performing a partial nephrectomy. We believe that this instrument may represent an important tool for performing nephron-sparing surgery via an open or laparoscopic approach. Clinical trials are in progress.

Animals

Effect of mineral oil on porcine urothelium.

Mineral oil has been used to facilitate ureteral stone extraction and to treat selected patients with infected residual urine. The purpose of this study was to evaluate the effect of mineral oil on the urothelium. Twelve adult female farm pigs underwent bilateral ureteral catheter placement under general endotracheal anesthesia. Retrograde pyelograms were performed and the ureteral diameters measured. Using a randomization protocol, six animals underwent injection of 10 mL of normal saline into one ureteral catheter and 50 mL of normal saline instillation into the bladder. In the remaining six animals, 10 mL of mineral oil was injected into one ureteral catheter and 50 mL of mineral oil into the bladder. The instillation was maintained for 30 minutes, and then the catheters were removed. One week later, under general endotracheal anesthesia, cystoscopy and retrograde pyelography were performed to measure the diameter of the ureters, and the animals were euthanized. The bladder, ureters, and kidneys were harvested for macroscopic and histopathologic evaluation. There was no significant difference in the diameter of the ureters injected with normal saline, the uninjected ureters, or the mineral oil-injected ureters. The bladders, ureters, and kidneys were grossly normal in all animals. No significant histopathologic changes were noted in the ureteral or bladder urothelium or the renal parenchyma in the animals injected with mineral oil. In conclusion, the instillation of mineral oil within the urinary tract does not have any significant long-term functional or histopathologic effect on the urothelium.

Animals

Techniques for stenting the normal and obstructed ureter.

Ureteral obstruction is a common cause of urologic morbidity requiring quick and effective treatment, as prolonged obstruction can cause pain, infection, and eventual loss of renal function. Few would argue that initial drainage or bypassing of the obstruction is favorable initial management; however, urologists are often-times faced with technically difficult cases not responsive to the standard operative maneuvers. Recognizing the diversity of pathology and the potentially complicating issues, urologists should have in their armamentarium a systematic approach or algorithm for dealing with these common dilemmas, as well as an understanding of various tricks of the trade. This knowledge will prevent heightened anxiety at the time of surgery and will ensure the availability of the proper operative equipment. This article outlines an approach and discusses the obstacles and options in stenting the obstructed ureter.

Humans

Preoperative assessment of ureteropelvic junction obstruction with endoluminal sonography and helical CT.

OBJECTIVE: Our objective was to compare the value of endoluminal sonography with the value of helical CT in the preoperative assessment of crossing vessels in patients with ureteropelvic junction (UPJ) obstruction. SUBJECTS AND METHODS: Thirteen patients with UPJ obstruction underwent contrast-enhanced helical CT with multiplanar reformations and endoluminal sonography. Imaging preceded surgery for UPJ repair. On imaging, vessels were considered significant if greater than or equal to 2 mm in diameter and within 1 cm of the UPJ. RESULTS: Three patients had no crossing vessels revealed by either study. On sonography, another patient had a vessel revealed with a diameter that varied between 1.3 and 2.2 mm; on CT no correlate was detected. The remaining nine patients had vessels revealed by both techniques. On CT, four patients had two vessels revealed and five patients had single vessels revealed for a total of 13 vessels revealed by CT. On sonography, five patients had two vessels revealed and five patients had single vessels revealed. Thus, 15 vessels were revealed by sonography. Both arteries and veins were revealed anterior, posterior, and medial to the UPJ; no lateral vessels were seen. Four patients underwent laparoscopy, during which the absence, presence, and location of vessels were found to correlate with sonography and helical CT. CONCLUSION: Endoluminal sonography and helical CT were similar in revealing crossing vessels in patients with UPJ obstruction.

Adolescent

Laparoscopic adrenalectomy for solitary metachronous contralateral adrenal metastasis from renal cell carcinoma.

PURPOSE: We report our experience with laparoscopic adrenalectomy for malignant adrenal disease. MATERIALS AND METHODS: Between June 1995 and January 1996, 2 patients with a solitary metachronous contralateral adrenal metastasis from renal cell cancer were evaluated. Both patients had undergone radical nephrectomy for localized renal cancer 5 years previously. Laparoscopic transperitoneal adrenalectomy was performed. RESULTS: The laparoscopic procedures required 2.5 and 4.3 hours. Hospital stay was 3 and 4 days. The specimens weighed 98 and 81 gm. All surgical margins were free of metastatic clear cell cancer. Both patients were begun on prednisone and fludrocortisone replacement therapy. One patient experienced an increase in creatinine, which has since stabilized at 3.0 mg/dl. Neither patient had recurrent cancer at 11 and 16 months of followup. CONCLUSIONS: Laparoscopic adrenalectomy for metastatic renal cell cancer was performed successfully in 2 patients. However, the short-term benefits to the patient of earlier ambulation, decreased pain, minimal incisions and shortened convalescence must be weighted against the as yet unknown long-term (5 years) results.

Adrenal Gland Neoplasms

Laparoscopic pneumodissection: results in initial 20 patients.

BACKGROUND: The efficiency of laparoscopic procedures has been hindered by a lack of instrumentation for blunt tissue dissection. We evaluated here the efficacy of a new 5-mm laparoscopic dissecting instrument, a pneumodissector. This instrument allows the surgeon to use short bursts of high-pressure carbon dioxide to bluntly dissect fatty tissue. STUDY DESIGN: In 20 patients undergoing a variety of laparoscopic procedures, a 5-mm laparoscopic pneumodissector was used. Subjective assessment of the efficacy of the instrument was recorded. In addition, acid-base changes were measured by blood gas determination, and serum chemistries were obtained before, during, and after the procedure. RESULTS: The pneumodissector enhanced dissection of the kidney, ureter, and major blood vessels and shortened the operative time for laparoscopic nephrectomy. Although statistically significant changes in acidbase values occurred with use of the pneumodissector, these changes were not clinically significant and were no different than what is normally seen during carbon dioxide pneumoperitoneum. CONCLUSIONS: Laparoscopic pneumodissection is a safe and efficacious technique for rapid blunt tissue dissection.

Acid-Base Equilibrium

Incisional hernia after laparoscopic nephrectomy with intact specimen removal: caveat emptor.

PURPOSE: We report 5 cases of postoperative incisional hernia after laparoscopic nephrectomy with intact removal of the specimen. MATERIALS AND METHODS: During the last 5 years 29 patients underwent laparoscopic nephrectomy with intact removal of the resected specimen due to a large kidney and/or malignancy. Of these 29 patients 5 had a postoperative incisional hernia at the site of intact removal, including 3 with renal tumors and 2 with large polycystic kidneys due to adult onset autosomal dominant polycystic kidney disease. The records of these patients were reviewed to determine any specific factors that might relate to the development of this complication. RESULTS: An incisional hernia developed at the wound site in 5 patients (17%) 41 to 73 years old (mean age 53.4). Average body mass index for the patients was 34.2 (range 26 to 47). Average weight and size were 542 gm. and 20.3 x 10.3 cm., respectively, for the 3 resected malignant specimens and 1,975 gm. and 23.8 x 16.5 cm., respectively, for the 2 benign kidneys. A transverse lower flank muscle cutting incision (average 10.4 cm.) was performed to remove the resected kidney. Incisional hernias appeared after an average of 6.6 weeks postoperatively. Risk factors for a postoperative hernia included obesity in 80% of the patients, chronic renal insufficiency due to autosomal dominant polycystic kidney disease in 40%, postoperative pulmonary complication in 40% and metastatic cancer in 20%. CONCLUSIONS: Our experience has led us to avoid a lower flank port connecting incision for specimen removal. Instead we changed to a midline or subcostal incision in these patients. In addition, we believe that with the availability of the impermeable organ entrapment sacks there is less need for intact specimen removal even for renal tumors. Currently large benign kidneys (autosomal dominant polycystic kidney disease) are morcellated in situ to a suitable size for entrapment, while renal tumors are entrapped and morcellated directly. Presently our only indication for intact removal is in the case of a renal pelvic or caliceal transitional cell cancer.

Adult

Laparoscopic ablation of peripelvic renal cysts.

PURPOSE: We describe and define the operative techniques, findings and results of laparoscopic ablation of peripelvic renal cysts. MATERIALS AND METHODS: One male and three female patients, ranging in age from 35 to 59 years, underwent laparoscopic ablation of symptomatic peripelvic cysts. All patients had symptoms of ipsilateral flank pain and obstruction. One patient had an episode of pyelonephritis before detection of the cyst, and 2 patients had concomitant stones within the obstructed system. Cysts ranged in size from 4 to 6 cm. Dissection was uniformly complex because of the depth to which the cyst extended into the renal parenchyma and the overlying renal vessels and collecting system. RESULTS: Operative times ranged from 315 to 390 minutes (mean 338 minutes). The average length of hospital stay was 2.75 days (range 2 to 4 days). Three of 4 patients (75%) had resolution of their symptoms and collecting system obstruction. One patient, the only case of a retroperitoneal approach, had recurrence of her symptoms and cyst 2 months after the operation and required open surgical repair. CONCLUSIONS: Laparoscopic ablation of peripelvic cysts is a challenging yet feasible procedure. Because of the medial location of these cysts, a transperitoneal approach may be preferable to retroperitoneal access alone.

Adult

Ureterolysis for extrinsic ureteral obstruction: a comparison of laparoscopic and open surgical techniques.

PURPOSE: We evaluated the role of laparoscopy in the management of extrinsic ureteral obstruction due to benign retroperitoneal fibrosis or ovarian pathology. The results of laparoscopic ureterolysis were compared to those of a contemporary series of open ureterolysis performed for the same pathological conditions. MATERIALS AND METHODS: We compared 6 patients undergoing unilateral laparoscopic ureterolysis for extrinsic ureteral obstruction to 7 undergoing open unilateral ureterolysis for similar pathological conditions. Patient demographic, operative, and early and late postoperative data were collected. RESULTS: Laparoscopic ureterolysis was associated with less intraoperative blood loss and need for parenteral pain medications, and significantly shorter hospital stay and convalescence than open surgery. Although there were no intraoperative or postoperative complications in the laparoscopy group, 1 patient in the open surgery group had an intraoperative ureteral avulsion and 4 had minor postoperative complications (blood transfusion, ileus and/or wound cellulitis). Operative time was longer in the laparoscopy group (255 versus 232 minutes). Subjective followup with an analog pain scale and/or telephone interview showed improvement in all patients in the laparoscopy group and all 6 contacted in the open surgery group. Likewise, excretory urography and/or renal scan showed improved renal function and relief of obstruction in all patients. CONCLUSIONS: Laparoscopic unilateral ureterolysis for extrinsic ureteral obstruction is a less morbid, yet equally effective procedure with several clinical advantages over conventional open surgical ureterolysis.

Adolescent

Endourology.

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Endoscopy

Laparoscopic complications in markedly obese urologic patients (a multi-institutional review)

OBJECTIVES: Significant obesity is considered to be a relative contraindication to laparoscopic surgery. This study reviews the complications encountered in massively obese patients undergoing urologic laparoscopic surgery. METHODS: Body mass index (BMI) was used as an objective index to indicate massive obesity. Eleven institutions compiled retrospective data on 125 patients having a BMI greater than 30. Procedures performed included 76 pelvic lymph node dissections, 14 nephrectomies, 7 bladder neck suspensions, and 28 miscellaneous procedures. RESULTS: For the group as a whole, the mean BMI was 35.1 (range 30.1 to 57.2). Mean operative time was 202 minutes (range 60 to 480). Conversion to open surgery occurred in 15 of the 125 patients (12%). Complication rates (minor and major) were 22% (27 occurrences in 125 patients) intraoperatively and 26% (33 occurrences in 125 patients) postoperatively. The major complications included 2 trocar injuries to abdominal wall vessels, 1 bladder injury, 3 peripheral nerve injuries, 1 dysrhythmia, 1 deep vein thrombosis, 1 wound seroma, 1 nephrocutaneous fistula, 1 incisional hernia, and 1 death. CONCLUSIONS: In this review, complication rates for urologic laparoscopic surgery on massively obese patients were higher than in the general population undergoing laparoscopic surgery (0.3% to 21%).

Adolescent

Laparoscopy for adult polycystic kidney disease: a promising alternative.

The purpose of this study was to evaluate the efficacy of laparoscopy in managing patients with abdominal symptoms from autosomal dominant polycystic kidney disease (ADPKD). From April 1993 to July 1995, four patients with ADPKD underwent seven laparoscopic procedures: five cyst decortications were performed in two patients using a laparoscopic ultrasound unit and two laparoscopic nephrectomies were performed in two patients with end-stage renal failure. The mean operative time was 207 minutes for laparoscopic cyst decortication and 272 minutes for laparoscopic nephrectomy. The two nephrectomy specimens were 2,200 g and 1,750 g, respectively. The mean intraoperative blood loss was 85 mL. The patients resumed their oral intake within 10 hours after laparoscopic cyst decortication and within 16 hours after laparoscopic nephrectomy. The mean amount of parenteral analgesics required postoperatively was 12 mg morphine sulfate for cyst decortication and 30 mg morphine sulfate for nephrectomy. The mean hospital stay was 3 days for cyst decortication and 3.5 days for nephrectomy. The patients returned to their usual activities after an average of 2 weeks. Based on pain analog scales, all the patients have shown marked reduction in their symptoms (average, 90%) during an average follow-up period of 6.6 months. Laparoscopic cyst decortication and nephrectomy are effective minimally invasive treatment options for patients with adult polycystic kidney disease who are experiencing abdominal symptoms due to marked renal enlargement. We believe that by using a laparoscopic ultrasound unit, most renal cysts may be safely removed, and if need be, even "giant" kidneys can be removed laparoscopically. To the best of our knowledge, the two nephrectomy specimens in this study represent the largest kidneys removed laparoscopically to date and the first laparoscopic nephrectomies in ADPKD patients.

Adult

Correction of stress urinary incontinence: retropubic approach.

Urinary incontinence affects more than 10,000,000 Americans, a significant number of whom have stress urinary incontinence. Laparoscopic bladder neck suspension is an increasingly common treatment for this disorder. Performed by an extraperitoneal approach, this operation takes significantly longer than a transvaginal operation; but the postoperative analgesic requirements, period of urinary diversion, and hospital stay are far less, and the success rates are similar. Randomized trials and longer follow-up are necessary to substantiate the preliminary encouraging results of the laparoscopic operation.

Adult

Laparoscopic bladder seromyotomy: laboratory experience.

Twelve female microminipigs with normal bladder capacity underwent laparoscopic bladder seromyotomy. Three other female microminipigs were added to the study as controls. Urodynamic studies and cystograms were performed preoperatively and at 2 and 4 months after a laparoscopic bladder seromyotomy. Histologic studies of the treated bladders were performed when the animals were euthanized at 4 months. The operation was completed in all 12 test animals. There was no significant difference in bladder capacity or leak-point pressure between the 12 seromyotomy and the 3 control bladders at any time point. Histologically, over the seromyotomy site, the urothelium remained intact; however, the muscularis was attenuated, and a thin layer of fibrotic tissue replaced the normal serosal covering of the bladder. Laparoscopic bladder seromyotomy can be performed reliably in the porcine animal model. Not surprisingly, no significant changes in bladder capacity or bladder compliance were seen in our study of normal bladders. An animal model of a neuropathic contracted bladder is needed to assess more accurately the physiological impact of laparoscopic seromyotomy.

Animals

Comparison of three-dimensional and two-dimensional laparoscopic video systems.

The limitations of two-dimensional (2D) video may be overcome by the recent introduction of the three-dimensional (3D) laparoscope and video system. Twenty-two urologic and gynecologic surgeons experienced in laparoscopy were evaluated during a live porcine laboratory session in an advanced course designed to teach laparoscopic retroperitioneal nephrectomy and bladder neck suspension. The surgeons performed dissection of the kidney, securing of the renal vessels, laparoscopic suturing and intracorporeal knot-tying at the bladder neck, and suture clipping of an intracorporeally placed suture at the bladder neck using 2D and 3D equipment. The time needed to complete each technique was recorded and compared using nonparametric analysis. The participants' subjective evaluation of the 3D system was also analyzed. Three-dimensional video did not significantly improve the surgeons' ability to perform laparoscopic dissection of the kidney, securing the renal vessels, or laparoscopic suturing and knot-tying. Surgeons felt that the 3D system did not improve vision or perceived surgical performance sufficiently to justify an expense greater than that of the 2D systems now available. Compared with the standard 2D camera system, the currently available 3D video system does not hasten the laparoscopic dissection of tissues or the performance of advanced technical maneuvers such as laparoscopic suturing and knot-tying by experienced laparoscopists.

Adult