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Biomedical subjects

E M Mullin

Publications and source records attributed to E M Mullin.

17 recordsLinked to original sources
PubMed1984

Bilateral amyloidosis of the ureter associated with carcinoma.

We report a case of coexisting amyloid and neoplasm in a localized ureteral lesion. This case also represents the third reported instance of sequential bilateral ureteral amyloidosis. Right nephroureterectomy revealed amyloid and an in situ focus of low grade transitional cell carcinoma. Three years later amyloid in the distal left ureter was resected and the gap was bridged by a bladder hitch and Boari flap. Subsequent followup has been uneventful.

Amyloidosis↗
PubMed1976

Renal cystic disease.

Renal cystic disorders have long represented an area of diagnostic confusion. We have attempted to correlate renal microdissection findings with clinically established renal cystic disorders by examining each disorder in sequential fashion. The clinical presentation of a child with a multicystic kidney is followed by a review of the cystic diseases with emphasis on clinical presentation, distinguishing factors, course, and prognosis.

Adolescent↗
PubMed1976

Bilateral renal carcinoma in von Hippel-Lindau Disease.

Von Hippel-Lindau disease, one of the phakomatoses, is believed to be a disorder of mesodermal differentiation. Renal lesions, usually cysts or adenocarcinomas with an occasional hemangioblastoma, occur in approximately two thirds of all patients. The renal neoplasms previously reported have been multiple, bilateral, and usually beyond resection. A thirty-eight-year-old white male with a cerebellar hemangioblastoma and bilateral renal adenocarcinoma underwent suboccipital craniotomy, right heminephrectomy, and left radical nephrectomy. No evidence of recurrent disease can be identified ten months postoperatively. An aggressive approach in this systemic disease appears to be warranted.

Adenocarcinoma↗
PubMed1976

Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery.

Male Charles River mice, divided into control or experimental groups, received on Day 0 either sterile 0.3 MNaHCO3 in 0.9 per cent saline (pH7.4) intraperitoneal injection or pteroylglutamic acid (200 mug per body weight), similarly buffered to pH7.6, and were sacrificed on Days 0, 1/4, 1/2, 1,2,3,4,7, and 14. The experimental kidneys demonstrated intratubular deposits of pteroylglutamic acid with edema between Days 1 and 4 with cortical scarring by Day 14. The experimental kidneys reached maximal increases in weight (+90 per cent) on Day 2, RNA (+61 per cent, protein (+67 per cent) on Day 3, and DNA (+25 per cent) on Day 4 before falling to below control levels on Day 14. The control kidneys demonstrated the gradual incremental increases of normal renal growth throughout this period. No change in renal size, protein, RNA, or DNA could be detected in those animals who failed to demonstrate renal tubular damage. It is postulated that the response of the kidney to folic acid administration is a reparative response and not a response directed toward accelerated renal growth.

Acute Kidney Injury↗
PubMed1975

Effect of transient hydronephrosis on subsequent compensatory renal growth.

Apparent augmentation of renal growth occurs in kidneys made temporarily ischemic, or partially obstructed, before contralateral nephrectomy. The study herein was undertaken to investigate the effect of acute complete ureteral occlusion on a subsequent course of renoprival hypertrophy and hypoplasia. Three groups of animals were established. Animals in Group 1 underwent high ligation of the right ureter. Animals in Groups 2 and 3 underwent exposure and manipulation of the right ureter. Forty-eight hours later, animals in Group 1 underwent deligation and contralateral nephrectomy, animals in Group 2 underwent contralateral nephrectomy, and animals in Group 3 underwent sham operation. Animals were then selected 6 and 17 days after their second operative procedure and decapitated; the right kidneys were removed and underwent analysis with respect to wet and dry weight, total RNA, DNA, and protein content. At 6 days and at 17 days, animals in Groups 1 and 2 demonstrated no difference between these groups, although the remaining kidneys from animals in Group 1 and Group 2 were significantly larger than Group 3 animals. When compared to Group 3 animals, wet renal weight at 17 days had increased by 41 per cent, total bulk RNA had increased by 26 per cent, and total bulk DNA had increased by 33 per cent. The data support the clinical impression that transient, complete ureteral obstruction is well tolerated by the normal kidney, and that the metabolic response to obstruction does not hinder recovery after release of obstruction.

Animals↗