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Biomedical subjects

E M Ophus

Publications and source records attributed to E M Ophus.

7 recordsLinked to original sources
PubMed1981

Massive pulmonary deposition of rutile after titanium dioxide exposure: Light-microscopical and physico-analytical methods in pigment identification.

Autopsy findings in a 55-year old man known to have been occupationally heavily exposed to titanium dioxide dust showed extensive pulmonary deposition of white pigment. By energy dispersive X-ray analysis (EDAX) and electron and X-ray diffraction, the pigment was identified as rutile. By ordinary transmitted light microscopy, deposits of the white crystalline titanium-dioxide could not be distinguished from anthracotic pigment present in the lung sections. By transmitted polarized and incident light microscopy, the different nature of the two types of pigment was immediately evident. Absence of inflammatory and fibrotic changes in the lungs in our case lends support to the view that rutile is biochemically inert.

Environmental Exposure↗
PubMed1980

Scanning electron microscopy and x-ray microanalysis of mineral deposits in lungs of a patient with pleural mesothelioma.

Scanning electron microscopy of lung tissue, ashed at low temperature, and obtained from an insulation worker who had died of pleural mesothelioma, showed the presence of numerous inorganic particles and fibres. A regional variation in fibre concentration in different tissue samples was found, and the size distribution of naked fibres and asbestos bodies was determined. By energy dispersive x-ray microanalysis the fibres were identified mainly as amphibole asbestos. This method also showed the presence of particles containing titanium and of fragments of diatom shells. Despite a mean concentration of 33 x 10(6) fibres per gram of dry tissue no significant lung fibrosis was found.

Adult↗
PubMed1979

Determination of inorganic fiber density in human lung tissue by scanning electron microscopy after low temperature ashing.

The concentration of asbestos fibers in lung tissue may give information about previous occupational asbestos exposure. A procedure for the preparation, quantification and identification of asbestos fibers in human tissue is presented in this report. The procedure is based on low-temperature plasma ashing of dry tissue, examination of the ash by scanning electron microscopy, and energy dispersive X-ray microanalysis. The advantages and disadvantages of this method are also discussed briefly.

Asbestos↗
PubMed1977

Pulmonary distributions of lead in human subjects.

The concentration of lead in five lung segments and in regional lymph nodes was determined post mortem in ten subjects by atomic absorption technique. In each case there was a considerable variation in the concentration of lead in different lung segments, and, in general, the apical segment in the upper lobe tended to be more contaminated than segments in the lower lobes. With one exception, the lead levels in the regional lymph nodes exceeded those of the lung segments. Individual differences in the distribution of lead in the lungs may be due to differences both in exposure and physiological response. When comparative analyses are made, we suggest that samples be taken from the same and preferably the basal segments of the lung.

Adult↗