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Biomedical subjects

E M Parsch

Publications and source records attributed to E M Parsch.

9 recordsLinked to original sources
PubMed1994

Inhibition of angiotensin-converting enzyme--a new concept of medical treatment of male infertility?

OBJECTIVES: To evaluate the effectiveness of systemic captopril therapy. DESIGN: Randomized double-blind study. SETTING: Andrology Unit at the Department of Dermatology, University of Munich, Munich, Germany. PATIENTS: Infertile men suffering from oligozoospermia (5-20 x 10(6) spermatozoa/mL) and/or asthenozoospermia. INTERVENTIONS: Captopril was given orally; samples of seminal plasma were collected twice before treatment and 4 and 12 weeks after captopril administration. MAIN OUTCOME MEASURE: Semen parameters, pregnancy rate, ACE activity, and kinin levels. RESULTS: After 4 weeks of therapy, significant differences between verum group and placebo group were found concerning ACE activity and kinin levels. Sperm density improved significantly after 12 weeks of captopril therapy. All other semen parameters remained unchanged. The pregnancy rate was not improved. CONCLUSIONS: The suitability of captopril in the therapy of oligozoospermia and/or asthenozoospermia for improvement of male infertility seems to be limited.

Adolescent↗
PubMed1988

[Pathophysiology of secondary testicular dysfunction].

This review summarizes the most important forms of secondary testicular dysfunctions. The gonads are controlled by overlapping regulation systems. Disturbances within these systems possibly lead to gonadal dysfunction. Physicians should be aware of factors that might have a pathogenic effect on gonadal functions, because only then is it possible to prevent infertility.

Gonadal Steroid Hormones↗
PubMed1988

[Pathophysiology of primary testicular dysfunction].

This review summarizes the most important forms of primary testicular dysfunction with particular reference to new pathophysiological concepts that may lead to a better understanding of primary testicular dysfunctions. The observed abnormalities can be used as a model to understand the multiple interactions of the different gonadal compartments.

Humans↗
PubMedDate not supplied

Semen parameters and conception rates after surgical treatment and sclerotherapy of varicocele.

Varicocele is an important cause of male subfertility which may lead to varying degrees of pathological semen quality. Removal of varicocele can be an effective andrological treatment if associated with subfertility. Therefore, in a retrospective study, two possible methods of treatment, high ligation and transcatheter sclerotherapy, were compared with regard to semen parameters and conception rates. Three months after treatment, only high ligation showed a significant improvement of sperm concentration, morphology and motility. Sperm concentration and motility, however, similarly increased in both groups after six to nine months. Sclerotherapy showed a better conception rate of 25% than the surgical group with 14%. Sclerotherapy should be the treatment of first choice if associated with subfertility.

Adult↗
PubMedDate not supplied

Andrological investigations in men treated with acitretin (Ro 10-1670).

Ten subjects were treated orally with acitretin (Ro 10-1670) over a period of 3 months. Before, during and after treatment, semen and blood analyses were performed to investigate drug-induced impairment of spermatogenesis and the hypothalamic-pituitary-gonadal axis. Our study concludes that acitretin in therapeutically effective doses does not influence spermatogenesis, sperm morphology, sperm motility and the hypothalamic-pituitary-gonadal axis.

Acitretin↗
PubMedDate not supplied

Modern techniques of sperm preparation--do they influence the sex of offspring?

Four different semen preparation methods--migration-Sedimentation technique, Sperm Select, Percoll gradient centrifugation and swim-up technique--have been tested and compared in regard to progressive motility, viability and morphology. The data obtained clearly demonstrate significant enhancement of all parameters using the techniques mentioned above. The study also demonstrated significant differences in Y chromatin-positive spermatozoa before and after semen preparation. The rate of F-body-positive spermatozoa was significantly increased by all four methods.

Female↗