Biomedical subjects

E M Pedersen

Publications and source records attributed to E M Pedersen.

92 records · Page 6Linked to original sources

PubMedDate not supplied

Numerical simulation and experimental validation of blood flow in arteries with structured-tree outflow conditions.

Blood flow in the large systemic arteries is modeled using one-dimensional equations derived from the axisymmetric Navier-Stokes equations for flow in compliant and tapering vessels. The arterial tree is truncated after the first few generations of large arteries with the remaining small arteries and arterioles providing outflow boundary conditions for the large arteries. By modeling the small arteries and arterioles as a structured tree, a semi-analytical approach based on a linearized version of the governing equations can be used to derive an expression for the root impedance of the structured tree in the frequency domain. In the time domain, this provides the proper outflow boundary condition. The structured tree is a binary asymmetric tree in which the radii of the daughter vessels are scaled linearly with the radius of the parent vessel. Blood flow and pressure in the large vessels are computed as functions of time and axial distance within each of the arteries. Comparison between the simulations and magnetic resonance measurements in the ascending aorta and nine peripheral locations in one individual shows excellent agreement between the two.

Adult↗

PubMedDate not supplied

Continuous registration of cardiac output with a new computer system designed for hot-film anemometry: an in vitro study.

We have developed and improved a method for the continuous on-line registration of cardiac output. By measuring blood velocity with a hot-film anemometer probe in the pulmonary artery, cardiac output can be estimated by gated systolic integration of the velocity signals. The integrated value for a certain period can be converted to a cardiac output proportional value. A thermistor placed next to the velocity probe enables thermodilution measurement of cardiac output, which serves as in vivo and in situ calibration. In this paper an in vitro study of the method applied to pulsatile flow is presented. A good correlation was found between real flow and both the velocity method and the thermodilution method. Fluid temperature and changing stroke volume and/or pulse frequency had minimal influence on accuracy, whereas altered probe position required recalibration for the velocity method but not for the thermodilution method. The advantages of the velocity method for the measurement of cardiac output are: The continuous on-line monitoring of cardiac output. The need for the injection of only very small volumes of cold saline, as the frequency of thermodilution measurements is reduced.

Cardiac Output↗