Hairy cell leukemia--cell characteristics and morphology.
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Biomedical subjects
Publications and source records attributed to E Machado.
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A family history encompassing four generations is presented. Definite cyclic neutropenia has been noted in two generations. In one member, the symptoms abated as she grew older. One 12-year-old member died of clostridial septicemia secondary to gangrene of the terminal ileum. At autopsy he was found to have amyloidosis. A trial of lithium carbonate therapy was carried out in a 7-year-old male but a positive hematologic response was not obtained.
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Chronic myelogenous leukemia (CML) cells from line K-562, containing the Philadelphia (Ph1) chromosome, were transplanted into nude mice and grew as solid vascularized tumors containing cells like those seen in the patient and in the cultures. Cells taken from the tumors were near triphoid and retained all human chromosome markers in culture.
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