Biomedical subjects
Publications and source records attributed to E Macotela-Ruiz.
A previously undescribed genodermatosis consisting of tiny hyperpigmented spots aggregated in irregular maculae and mainly localized in the regions exposed to light is reported. Hyperkeratotic papules in the palms and soles were also present. Autosomal dominant inheritance is concluded.
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In this paper, we report a case of sarcoidosis, in a 15-years-old boy. Clinical picture has cutaneous findings as only manifestation. Clinical approach was oriented by reticulosis. Diagnosis of sarcoidosis, was based in scans that shows pulmonary involvement. Lastly, granulomatoses disorders most common in our country, like tuberculosis and leprosy, were excluded.
Fifty-eight patients with cutaneous leukocytoclastic vasculitis were evaluated. The most frequent cutaneous manifestation was purpura, followed by palpable purpura. Vascular inflammation was confirmed by skin biopsy: two distinct patterns of cellular infiltrate were found, a neutrophilic-predominant and a mononuclear-predominant type, as a manifestation of the dynamic evolution of the process. On the basis of the associated disease we grouped our cases as follows: autoimmune disease, reaction, malignancy, infection and idiopathic.
The purpose of this review is to describe M. leprae antigenic structures that are considered relevant for the development of a vaccine. Other biological elements presently utilized in vaccination and immune therapy against leprosy are also reviewed, and the possibility of having in the future an effective vaccine obtained at low cost through molecular biology recombinant techniques. This review also describes some epidemiological and control aspects of leprosy within the general framework of the importance of this disease.
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