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Biomedical subjects

E Magid

Publications and source records attributed to E Magid.

At least 55 records · Page 3Linked to original sources
PubMed1985

A randomized trial of iohexol versus amidotrizoate in endoscopic retrograde pancreatography.

To evaluate whether a low-osmolar contrast medium could decrease hyperamylasemia after endoscopic retrograde pancreatography, a prospective randomized double-blind trial of 54 consecutive patients with suspected pancreatic disease referred for endoscopic retrograde pancreatography was performed. The low-osmolar contrast medium iohexol and high-osmolar amidotrizoate were used. No statistically significant differences with regard to rise in pancreatic-type amylase, pain reaction, or diagnostic information were found. No case of acute pancreatitis was observed.

Adult↗
PubMed1984

Serum amylase during recovery from diabetic ketoacidosis.

To elucidate the mechanism of the hyperamylasaemia which is often found in diabetic ketoacidosis, 9 patients who were admitted in this disease state were studied. Blood samples were taken every 4 hours for the first 24 hours and thereafter daily for 7 days. Serum amylase concentration increased gradually in all patients, from 256 (65-1155) U/1 at the initial sampling to a maximum of 1160 (210-2670) U/1 20-24 hours later (p. greater than 0.01), median values with 95% confidence limits. Simultaneously, plasma inorganic phosphate concentrations decreased from a median value of 1.35 mmol/l to 0.45 mmol/l (p less than 0.01), and a significant negative correlation was found between the changes in these parameters in 5 patients. Isoenzyme analysis in 8 of the patients showed that hyperamylasaemia was of the "salivary type" in two and of the "pancreatic type" in two. None of the patients had clinical signs of pancreatitis. It is concluded that in diabetic ketoacidosis, the increase in serum amylase concentration observed in all patients is closely related to the action of insulin in the majority of these, and some possible mechanisms are discussed.

Adolescent↗
PubMed1984

Serum immunoreactive trypsin, pancreatic polypeptide, and pancreatic isoamylase as diagnostic tests for chronic pancreatitis.

The efficiency of immunoreactive trypsin (IRT), pancreatic polypeptide (PP), and pancreatic isoamylase (PI) in the diagnosis of chronic pancreatitis was studied in 80 consecutive patients clinically suspected of having chronic pancreatitis. Twenty-five patients had chronic pancreatitis, and of these, 17 had pancreatic insufficiency. IRT, PP, and PI were of no value in the diagnosis of chronic pancreatitis without insufficiency. The three tests were of equal but limited value in diagnosing pancreatic insufficiency (nosographic sensitivities, 0.53 to 0.59, and predictive values of a negative test, 0.88 to 0.90). The combination of IRT, PP, and PI did not increase the diagnostic efficiency compared with each of the three tests alone. We conclude that IRT, PP, and PI are of similar but limited value as diagnostic tests for pancreatic insufficiency.

Adult↗
PubMed1983

Comparison of an open and a closed tube system for collection of jejunal juice.

When jejunal juice is obtained by means of open pernasal tubes, the risk of the aspirates being contaminated is presumably high. The present study compares jejunal aspirates obtained from an open and from a closed tube system. Ten patients suspected of having abnormal jejunal flora and five healthy human volunteers were investigated. The pH values of aspirates obtained from the open tubes were significantly lower than the values registered in aspirates from the closed tube system, with a median difference of 0.70 (p less than 0.02). No differences between the two types of aspirate were registered with regard to total number of bacteria, number of bacterial species, lipase, total protein, total amylase or its fractions of pancreatic and salivary isoamylases. For the investigation of pH-sensitive substances in jejunal juice, a closed tube system is therefore recommended, whereas the use of such a device does not seem necessary for the study of bacterial microflora and pancreatic enzymes.

Adult↗
PubMed1983

Serum isoamylases in Sjögren's syndrome. Concentration levels and intra-individual variation.

A study of isoamylase in serum from 53 patients with Sjögren's syndrome demonstrated that the levels of both pancreatic type and salivary type amylases remain within reference value limits in most cases. However, abnormal low or high values for pancreatic type amylases were seen more frequently than in the control groups. The intra-individual variation in concentration levels of both isoenzymes among patients with Sjögren's syndrome were significantly greater than in the control groups. These observations are interpreted as signs of subclinical lesions of the pancreas and the salivary glands occurring during the course of the disease. Sjögren's syndrome should be borne in mind and sought in cases of unexplained hypo- or hyperisoamylasemias.

Adult↗
PubMed1981

Immunoreactive trypsin and pancreatic isoamylase activity in serum of patients with chronic renal failure or hepatic cirrhosis.

In 121 patients with either liver cirrhosis or chronic renal failure, abnormal values for the concentrations of two pancreatic enzymes in serum were a frequent finding. In renal insufficiency a decreased rate of enzyme elimination is the most likely cause of the above-normal values we observed for serum immunoreactive trypsin and pancreatic isoamylase activity. As for patients with liver cirrhosis, we believe that changes in entrance rates into the blood--i.e., an affected pancreas--is a likely explanation of the abnormally high values we often found for these serum enzymes.

Adult↗
PubMed1980

Concentration of immunoreactive trypsin and activity of pancreatic isoamylase in serum compared in pancreatic diseases.

We measured the concentration of immunoreactive trypsin and the enzymic activity of pancreatic isoamylase in sera from 103 patients with pancreatic diseases and 29 other subjects serving as a reference group. Almost all patients with pancreatic diseases had abnormal values for both enzymes. A strong positive correlation between these two variables over a 1000-fold range was observed.

Acute Disease↗
PubMed1977

Serum pancreatic isoamylases in the diagnosis of cystic fibrosis heterozygotes: A non-valuable test.

A group of 102 obligate heterozygotes for the cystic fibrosis gene were examined for genetic type of pancreatic isoamylases as well as enzyme activity of pancreatic iso-amylases, salivary isoamylases and total amylase in serum. The analysis was performed using electrophoretic separation for detection of the various types of isoamylases, and their relative activity was determined by means of densitometry. The activities of salivary isoamylases and total amylase in serum showed no significant differences between the cystic fibrosis heterozygotes and a control group. The frequency of the variant gene for pancreatic isoamylase was also the same as in the controls. The mean value for pancreatic isoamylase was slightly higher in the cystic fibrosis heterozygotes than in the control group (0.05 greater than P greater than 0.02).

Adult↗
PubMed1977

On the quantitation of Iso-amylases in serum and the diagnostic value of serum pancreatic type amylase in chronic pancreatitis.

The object of this study is to elucidate whether the quantitative determination of serum pancreatic type iso-amylase can be used as a diagnostic test for exocrine pancreatic insufficiency. We describe the normal appearance of serum amylase zymograms produced with an agarose electrophoresis technique and the reference values from studies of 142 normal subjects for salivary and pancreatic type amylases. The patient group comprises 95 cases assumed to be representative of a patient population in which verification or exclusion of a diagnosis of chronic pancreatitis is of importance. In this group exocrine pancreatic function has been assessed by means of the Lundh meal test. We find that a low serum pancreatic type amylase value indicates the presence of a reduced exocrine pancreatic function (p = 0.96), and that a normal or elevated serum pancreatic type amylase value excludes the presence of a severe exocrine pancreatic insufficiency (p = 0.91). We also describe the occurrence of an abnormal amylase fraction which may be of diagnostic significance in pancreatic disease.

Adult↗