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E Mahon

Publications and source records attributed to E Mahon.

10 recordsLinked to original sources
PubMed2000

A "good hour" in child analysis and adult analysis.

An attempt is made to compare and contrast a "good hour" in child and adult psychoanalysis. Since all analytic hours reflect the conflicted vicissitudes of an associative process, what function can it serve to isolate certain specific hours as "good"? While analytic process always reflects the simultaneous impulse to reveal and to conceal, it is argued that at times the mind "surprises" itself with its own daring and savors the epiphany before the forces of defense make off with it again. A child's surprising formulation of the nature of transference and therapeutic alliance is compared to an adult's more mature grasp and use of the same concept. Analysis and creativity are compared as activities that nourish and foster surprise elements, creating new stabilities out of their tolerance for instability and destabilization. Childhood is emphasized as the crucible par excellence where surprises are not only engendered but integrated. Child analysis may be more accustomed to surprises and perhaps can contribute to adult analytic experience by way of this unusual expertise. The elements of surprise in certain analytic hours are discussed in terms of their developmental psychoanalytic components. Hours can be termed "good" as long as the implication that more defensive hours are "bad" is resisted with the psychoanalytic conviction that the mind reflects the human condition and that therefore nothing human is alien to it. As Shakespeare put it, there is nothing either good or bad but thinking makes it so!

Adult↗
PubMed2000

Parapraxes in the plays of William Shakespeare.

Parapraxes in the psychopathology of everyday life are "mistakes" that reveal the workings of the unconscious. (Obviously they existed before Freud's time, but it was Freud who gave them a name and dissected their complex psychological meanings.) When they occur in a great work of art (as in Shakespeare's plays) they are obviously not "mistakes" at all but carefully planted details of the artist's over-all aesthetic conception. Just as fictional dreams, as in Jensen's Gradiva, seem to follow the rules of nocturnal dream process and can be subjected to psychoanalytic scrutiny, fictional parapraxes are doubly interesting because they not only express the inwardness of a protagonist but reveal something of the writer's aesthetic method as well. This paper attempts to address these double points of entry into the mystery of Shakespeare's plays, posing the question, "Can the seemingly trivial or irrelevant (a handful of parapraxes in 38 plays) shed any light on the most complex characters in Western literature and the extraordinary mind of their creator?"

Amnesia↗
PubMed1999

beta-arrestins regulate interleukin-8-induced CXCR1 internalization.

The functional role of neutrophils during acute inflammatory responses is regulated by two high affinity interleukin-8 receptors (CXCR1 and CXCR2) that are rapidly desensitized and internalized upon binding their cognate chemokine ligands. The efficient re-expression of CXCR1 on the surface of neutrophils following agonist-induced internalization suggests that CXCR1 surface receptor turnover may involve regulatory pathways and intracellular factors similar to those regulating beta2-adrenergic receptor internalization and re-expression. To examine the internalization pathway utilized by ligand-activated CXCR1, a CXCR1-GFP construct was transiently expressed in two different cell lines, HEK 293 and RBL-2H3 cells. While interleukin-8 stimulation promoted CXCR1 sequestration in RBL-2H3 cells, receptor internalization in HEK 293 cells required co-expression of G protein-coupled receptor kinase 2 and beta-arrestin proteins. The importance of beta-arrestins in CXCR1 internalization was confirmed by the ability of a dominant negative beta-arrestin 1-V53D mutant to block internalization of CXCR1 in RBL-2H3 cells. A role for dynamin was also demonstrated by the lack of CXCR1 internalization in dynamin I-K44A dominant negative mutant-transfected RBL-2H3 cells. Agonist-promoted co-localization of transferrin and CXCR1-GFP in endosomes of RBL-2H3 cells confirmed that receptor internalization occurs via clathrin-coated vesicles. Our data provides a direct link between agonist-induced internalization of CXCR1 and a requirement for G protein-coupled receptor kinase 2, beta-arrestins, and dynamin during this process.

Animals↗
PubMed1999

A comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived beta-glucocerebrosidase: implications for clinical efficacy in treatment of Gaucher disease.

The objective of these studies was to characterize the macrophage mannose receptor binding and pharmacological properties of carbohydrate remodeled human placental-derived and recombinant beta-glucocerebrosidase (pGCR and rGCR, respectively). These are similar but not identical molecules that were developed as enzyme replacement therapies for Gaucher disease. Both undergo oligosaccharide remodeling during purification to expose terminal mannose sugar residues. Competitive binding data indicated carbohydrate remodeling improved targeting to mannose receptors over native enzyme by two orders of magnitude. Mannose receptor dissociation constants (Kd) for pGCR and rGCR were each 13 nmol/L. At 37 degrees C, 95% of the total macrophage binding was mannose receptor specific. In vivo, pGCR and rGCR were cleared from circulation by a saturable pathway. The serum half-life (t1/2) was 3 minutes when less than saturable amounts were injected intravenously (IV) into mice. Twenty minutes postdose, beta-glucocerebrosidase activity increased over endogenous levels in all tissues examined. Fifty percent of the injected activity was recovered. Ninety-five percent of recovered activity was in the liver. Parenchymal cells (PC), Kupffer cells (KC), and liver endothelium cells (LEC) were responsible for 75%, 22%, and 3%, respectively, of the hepatocellular uptake of rGCR and for 76%, 11%, and 12%, respectively, of the hepatocellular uptake of pGCR. Both molecules had poor stability in LEC and relatively long terminal half-lives in PC (t1/2 = 2 days) and KC (t1/2 = 3 days).

Animals↗
PubMed1998

A parapraxis in Hamlet. A note on the aesthetic genius of William Shakespeare.

Shakespeare has placed a parapraxis in Hamlet's mouth in the soliloquy in Act I. Hamlet says, "But two months dead, nay not so much not two." The slip attributed to Hamlet is of course no slip at all when seen as an aesthetic contrivance of the bard's to suggest the tension between warring aspects of Hamlet's psychology. I argue that Shakespeare's artistic methodology, his aesthetic sleight of hand, so to speak, which layers this complex drama with meanings concealing other meanings, supports Freud's notion that an unconscious latent oedipal drama underlies the whole manifest content, imbuing it with subtle but substantial dramatic tension. The slip of the tongue is not only a window into the unconscious of Hamlet that sheds light on the hero's Oedipus complex and the complexities of his attempted resolutions, it is also an example of Shakespeare's aesthetic subtlety at its most refined.

Authorship↗
PubMed1985

Some aspects of separation and loss in therapy with disturbed children.

I have suggested that the impact of loss and separation on disturbed children can best be assessed from a developmental point of view that takes into account not only the reality of the object loss but the subjective experiences of the loss or separation, which will be determined by a host of subtle psychological variables. I have attempted to illustrate these existential variables with clinical examples.

Anxiety, Separation↗