Biomedical subjects

E Makó

Publications and source records attributed to E Makó.

15 recordsLinked to original sources

PubMed1998

[High-resolution computer tomography of diffuse infiltrative lung diseases].

During a period of 17 months, a total of 101 patients were examined by high resolution computed tomography (HRCT) whose minor focal changes revealed by chest X-ray raised the suspicion of diffuse infiltrative pulmonary disease. The disease of the interstitium was primarily caused by idiopathic pulmonary fibrosis (19%), autoimmune disease (18%), Boeck sarcoidosis (18%) as well as by specific (16%) and aspecific inflammation (12%). HRCT disclosed reticular (61%), nodular (55%), ground-glass opacity-like (48%), emphysematous (33%) and ring-like changes (17%). Also transbronchial excision was performed in 51 patients the results of which were compared to the changes observed during HRCT. Concerning fibrosis and inflammation, HRCT and histological analysis showed identical results in 70%. According to the authors observations, this technique is suitable for detection of fairly fine fibrotic, empysematous and inflammatory signs and for defining the activity of the individual disease as also for the selection of the optimal site of transbronchial excision. HRCT is a useful investigative method both for diagnosing diffuse infiltrative pulmonary disease as well as in following up the effectiveness of treatment.

Diagnosis, Differential↗

PubMed1998

Increased interleukin-6 levels, interleukin-6 receptor and gp130 expression in peripheral lymphocytes of patients with inflammatory bowel disease.

Interleukin-6 is one of the most well-characterized cytokines with pleiotropic properties. Besides its B-lymphocyte activation role in hematopoiesis, interleukin-6 plays a central role in regulation of systemic inflammation. Interleukin-6 binds to receptors on target cells (such as hepatocytes and lymphocytes), consisting of an 80 kDa binding chain and gp130, a polypeptide responsible for signal transduction. In addition to the detection of elevated amounts of interleukin-6 in the blood, gene expression (mRNA) of subunits of the interleukin-6 receptor complex have also been studied by examining the reverse transcriptase polymerase chain reaction on peripheral lymphocytes from patients with characteristic radiological symptoms suffering from Crohn's disease. Our data show significantly elevated gene expression both of the 80 kDa interleukin-6 binding chain and gp130. These results suggest that enhancement of the expression of the constituents of interleukin-6 and the interleukin-6 receptor system plays a relevant role in systemic inflammation in inflammatory bowel disease.

Antigens, CD↗

PubMed1997

Imaging of primary small intestinal tumours by enteroclysis and CT with pathological correlation.

Preoperative diagnosis of primary small intestinal neoplasms can be a challenge for both clinicians and radiologists. As a result of their infrequent occurrence, they invariably present difficult problems in diagnosis and management. These problems are reflected mainly in the delayed treatment and a very poor prognosis for such malignant tumours. Their morphological changes, however, shown in enteroclysis and CT, correlate almost perfectly with the lesions identified in the gross pathological specimens. This ability to accurately image a small intestinal neoplasm, independently of its size, anatomical localization and growing tendency, represents a major improvement in the diagnosis and management of these neoplasms. This paper, based on a large series of patients with primary small intestinal neoplasms, focuses on the recognition of their detailed radiological appearances when evaluated by enteroclysis and CT.

Barium Sulfate↗

PubMed1996

[Small intestinal leiomyoma causing gastrointestinal hemorrhage].

Leiomyomas are uncommon benign tumors of smooth muscle which may occur wherever smooth muscle is present. The small bowel is the most frequent site. Bleeding is the most common presenting symptom. Other symptoms, nausea, vomiting, abdominal pain are rare. In this article a 44 year-old male, presented, who was admitted with intermittent gastrointestinal bleeding in requence of jejunal leiomyoma with exulceration.

Adult↗

PubMed1995

[Crohn disease: diagnosis by graded compression ultrasound].

Fifty-four patients with suspected Crohn's disease of the small bowel underwent ultrasound examination with graded compression. The pathologic sonographic findings were compared with the clinical, endoscopic and in 32 cases with the parallel performed CT and selective enterographic examinations. Of the 29 proven cases of Crohn's disease 26 (89.7%) had bowel wall thickening detectable with US. The change in the bowel wall structure correlated to the stage of the disease. The luminal narrowing, the mesenteric involvement, the enlargement of the mesenteric lymph nodes, the abscesses and fistulas were judged easily, but the length and the location of the bowel segment were estimated only approximately. The characteristic but nonspecific signs observed by ultrasound were found to be a useful adjunct to the endoscopic and roentgen examinations. The ultrasound with graded compression in our view is a well usable alternative method for both diagnosis and follow-up, informing about the transmural spread of the pathology.

Abdomen↗

PubMed1995

[The value of ultrasonic diagnosis in acute appendicitis].

The diagnostic accuracy and practical value of graded compression ultrasound was evaluated in 298 patients admitted for ultrasound examination because of having suspected appendicitis by surgeons. The result of the ultrasound was considered to be positive, if the inflamed appendix, larger, than 6.5 mm in outer diameter or an abscess was depicted. Of the 99 pathologically proven cases of acute appendicitis ultrasound was positive in 94, that is the sensitivity was 94.9%. The diagnostic accuracy and specificity were 96.3% and 97.9%. The predictive value of a positive test was 95.9%, and was 97.5% of a negative one. In the group of patients under 18 years (140 patients) sensitivity, specificity and diagnostic accuracy were 93.3%, 96.3% and 95% respectively. The use of ultrasound helped many patients to earlier operation and reduced considerably the negative laparotomy rate. The routine use of ultrasound in the diagnosis of appendicitis especially if the clinical presentation is equivocal, complements usefully the clinical signs and increases diagnostic accuracy.

Acute Disease↗

PubMed1989

[Familial occurrence of carcinoid of the small intestine].

The case of a 41 year old woman has been reported, whose "flush" syndrome was caused by a carcinoid tumor originated from the jejunum. The patient's father had to be operated for intestinal carcinoid tumor several times. The occurrence of different forms of carcinoid tumors, especially in the gastrointestinal tract, has been discussed in connection with the diagnostic approaches and therapeutical possibilities. The authors considered the case interesting for publications, because carcinoid is a rather rare tumor, and one cannot find its familiar occurrence in the available literature.

Adult↗

PubMed1985

[Hysterosalpingography with the Foley catheter].

Five-hundred hysterosalpingographies with Foley-catheter were investigated and compared to that made with Schultze-instrument. The investigations were performed in both phases in cases of cyclic menstrual bleeding. The advantages of the method used are the followings: simple, atraumatic, painless. There was no flow-back of the contrast material, the shape of the internal genitals was visible in the proper position, moreover, the present method allowed an observation in the original state of the shape of the internal os and the cervical canal by a x-ray-amplifier. The method simplified the hydrotubations during and after plastic surgery on the fallopian tubes. The method can not be employed in the case of Asherman's syndrome, where the uterine cavity is significantly narrowed.

Catheterization↗

PubMed1984