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Biomedical subjects

E Malec

Publications and source records attributed to E Malec.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Tetralogy of Fallot in children--management and results of treatment].

The authors present the results of surgical treatment obtained in 288 children with tetralogy of Fallot. In 127 children palliative procedures (pulmonary-systemic anastomoses) were employed, whereas 161 patients were subjected to total surgical corrections of the defect, performed in cardiopulmonary bypass. In 127 (79%) belonging to the latter group the correction was a single stage procedure, and in 34 (21%), it followed pulmonary-systemic anastomoses. Perioperative mortality rate in children subjected to single stage procedures was 12%, being lightly lower than the rate observed in patients subjected to two stage procedures. The analysis of operative results corrected for age revealed a higher mortality rate in children operated when less then two years of age (17%) in comparison to older patients (11%).

Adolescent↗
PubMed1978

The changing incidence of malignant melanoma of the skin in Sweden, 1959-1968.

3289 cases of malignant melanoma of the skin, recorded in the Swedish Cancer Registry between 1959 and 1968, have been studied regarding sex, age, location, month of registration and mortality. The incidence showed a 7% annual increase. the increase was most pronounced on the trunk and legs in both sexes. The highest incidence rise for women was between the ages of 30 and 39 and for men in the age range 40-64. The incidence in women with melanoma on the legs was higher during the summer months June-August. Only a negligible change in mortality was found during the period under consideration.

Adult↗
PubMed1978

Sunlight and incidence of cutaneous malignant melanoma. Effect of latitude and domicile in Sweden.

The relationship between tumour incidence rate and habitation patterns was investigated in 3289 patients registered between 1959 and 1968 as cutaneous malignant melanoma in the Swedish Cancer Registry. A linear correlation analysis between latitude and melanoma incidence rate in various regions showed a coefficient, r, was -0.74, which implies a decreasing incidence with increasing latitude. This result supports the hypothesis that ultraviolet irradiation is the predominant cause of melanoma. However, considerable deviations from the regression line were seen in some regions. Moreover, a comparison between town and country indicated melanoma incidence increased with population density, an increase not explained by overdiagnosis and thus not in agreement with the working hypothesis of UV-irradiation as the predominant cause of melanoma. Increase of foreign travel, as estimated by passport issue, may explain the overrepresentation of melanoma in some regions namely city and county of Stockholm, city of Malmö and Göteborg county. As foreign travel in Sweden generally means sunshine trips, this town versus country paradox may also be explained on the basis of increased irradiation, as may the anomalies observed in some counties. A regression analysis of the epidemiological index for UV-irradiation and melanoma incidence, adjusted for foreign travel, demonstrated a close agreement with the results of the latitude gradient analysis.

Female↗
PubMed1977

Re-appraisal of malignant melanoma diagnosis in the Swedish cancer registry.

In many countries the registration of malignant melanoma of the skin shows an increased incidence; this may partially be due to an over-diagnosis. From the group of 3,268 adults and 21 children classified as suffering from malignant melanoma of the skin in the Swedish Cancer Registry between 1959-1968, a one-in-ten systematic sample survey was the object of a retrospective examination. 349 adults and 2 children had a uniform histopathological evaluation performed by one of the authors (B.L.). Slides were not available in 8 cases (2 per cent) and in the remaining 343, the diagnosis was regarded as incorrect in 13 (3.7 per cent). All these 13 cases, (2 children and 11 adults), showed no special predilection as to age, sex, location, or year of registration. In view of such a slight degree of error, the Swedish Cancer registry's melanoma group from 1959-1968 would seem suitable for further epidemiological studies.

Adolescent↗
PubMed1977

Malignant melanoma of the skin in children registered in the Swedish cancer registry during 1959-1971.

A clinical follow-up and histopathological reexamination of 26 cases originally diagnosed as malignant melanoma in children under 14 years of age registered in the Swedish Cancer Registry during 1959-1971 has been undertaken. Only one met current criteria of a malignant melanoma. This tumour occurred in a giant naevus in a 3-year-old girl, who died with widespread metastatic melanoma within a year. The other cases were reclassified as melanocytoma of Spitz, cellular blue naevus, compound naevus and neurofibroma. The results confirm that malignant melanoma is a rare tumour in prepubertal children. The risk for histophatological overdiagnosis is much higher in children (95%), than in adults (4%).

Adolescent↗