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Biomedical subjects

E Mallet

Publications and source records attributed to E Mallet.

At least 19 recordsLinked to original sources
PubMed1992

Long-term prevention of allergic diseases by using protein hydrolysate formula in at-risk infants.

This prospective, long-term study assessed the effects of a protein hydrolysate formula on allergy prevention in infants with a family history of allergy. Infants were randomly assigned to receive either the hydrolysate formula (n = 92) or an adapted cow milk formula (n = 85) alone or with breast-feeding for 4 months. The groups did not differ in family allergy history scores or cord blood IgE levels. After 4 months, total IgE levels and allergic reactions did not differ significantly between groups, although the hydrolysate group had a lower prevalence of eczema. At 12 months of age, neither IgE levels nor allergic reactions were significantly different. At 2 years of age, however, 18 allergic reactions had occurred in the hydrolysate group and 31 had occurred in the control group; the differences were significant for eczema (p < 0.001) but not for asthma. At 4 years of age, allergic signs were found in 11 children in the hydrolysate group and in 17 children in the control group; the difference was significant only for eczema (p < 0.01). These results suggest that early feeding of a protein hydrolysate formula to infants at risk for allergies had a long-term preventive effect on the prevalence of eczema but not of asthma.

Body Height↗
PubMed1992

Gastric secretion in infants. Application to the study of sudden infant death syndrome and apparently life-threatening events.

Sudden infant death is a problem of paediatric public health which remains an unpredictable phenomenon of unknown aetiology. Many authors have discussed the role of a neurovegetative aetiology, the role of the vagus nerve being suspected above all. A biological approach to vagal tone was attempted by assaying intragastric pepsin and serum pepsinogen and calculating the ratio of pepsin to acid in control infants, and by assaying serum pepsinogen levels in infants having suffered an apparently life-threatening event (ALTE) or who died of the sudden infant death syndrome (SIDS). This study showed that the age of 2 months appears to be a turning point in the development of digestive secretions, an age when the risk of SIDS is at its peak, and that the rates of the selected biological markers are significantly higher in victims of SIDS or ALTE than in controls. The predictive value of these biological markers is currently under evaluation.

Biomarkers↗
PubMed1992

GTP-dependent protein(Gs) activity in preterm infants.

In a previous study, we showed a renal resistance to PTH in preterm infants during their 1st week of life. We proposed it could explain early neonatal hypocalcemia. Such renal resistance is well known in type 1 pseudohypoparathyroid patients and is explained by a defect of stimulatory GTP-dependent protein (Gs). To determine if functional immaturity in the Gs protein could be involved in PTH resistance, we studied 27 newborn babies: 7 full-term and 20 preterm babies. Biological activity of the Gs unit was determined on days 1, 3 and 10 after delivery by bioassay. No correlation was found between the Gs unit activity and either gestation or birth weight at these dates. Eight infants had hypocalcemia and their Gs unit activity did not differ from those with normocalcemia. Furthermore, we showed that the Gs unit is active from 29 weeks of gestation. We conclude that the Gs protein appears not to be involved in the pathophysiology of early renal resistance to PTH and therefore in early neonatal hypocalcemia.

Adult↗
PubMed1992

[Insulin therapy using a portable pump in children. Apropos of a pediatric experience].

Experience accumulated with 17 pediatric patients with insulin-dependent diabetes mellitus treated with an insulin pump is reported. Follow-up exceeds four years in seven patients. A significant improvement in metabolic control was seen in only four patients and was confined to the first year of use of the pump. Overall, the improvement in control was not significant. Severe hypoglycemia was uncommon (0.27/patient-year). Ketoacidosis was rare (0.08/patient-year). Transient ketosis was the most common adverse event and was often related to technical problems which should immediately lead to appropriate action by patients who have received proper education. Use of an insulin pump remains an alternative which deserves to be considered when conventional therapies fail.

Adolescent↗
PubMed1991

[A prognostic study of cryptogenic infantile spasms].

The prognosis of infantile spasms is grim when a detectable brain lesion is present. In contrast, cryptogenic infantile spasms, in which there is no identifiable brain lesion, usually run a favorable course under treatment. Few studies have focused on the outcome in children with cryptogenic infantile spasms. Among 111 pediatric patients with a history of infantile spasms hospitalized over 18 consecutive years, 23 (21%) were given a diagnosis of cryptogenic infantile spasms. Follow-up ranged from 4 to 21 years. Outcome was as follows: the IQ was above 80 in 39% of cases and above 100 in 13% of cases; 42% of patients of school age were attending school but half of these had learning disabilities; 30% of patients had severe psychiatric disorders, and 22% had developmental delay and severe epilepsia. Early factors apparently associated with a good prognosis included the mild nature of psychomotor regression, persistence of spindles on EEGs recorded during NREM sleep, and prompt improvement of clinical status and EEG recordings under treatment. Conversely, severe regression, focalized EEG anomalies, failure of development to resume promptly after initiation of therapy, recurrence of spasms and hypsarrhythmia at discontinuation of treatment, and onset before 5 months or after 11 years of age were associated with a poor prognosis.

Adrenocorticotropic Hormone↗
PubMed1991

[The participation in sports of diabetic children. A survey in the Rouen region].

The purpose of this survey conducted during the 1987 academic year was to collect information on the participation in sports, whether at school or in athletic clubs, of 63 children followed on an outpatient basis for diabetes mellitus and to determine what steps are effectively taken by these children to prevent hypoglycemia. Simultaneously, the participation in sports of 200 children seen in a surgical outpatient clinic for any reason was determined. The data collected demonstrated that the diabetic children participated as actively as non-diabetic children in athletics at school and, in addition, were likely to participate in out-of-school non-compulsory sports (40% versus 27%). Approximately two out of three diabetic children reported attempting to prevent hypoglycemia during sports at school by an intake of carbohydrates before or after the activity and/or by a reduction in the dose of insulin acting during the activity, with variable results. Results suggested that hypoglycemic episodes tended to be overtreated, perhaps in part because the teachers were apprehensive about the possible negative effects of hypoglycemia. During out-of-school non-compulsory athletic activities, especially competitive sports, preventive measures against hypoglycemia were consistently taken and diary results seemed to improve steadily in patients who trained regularly several times a week. Lastly, in the population studied no correlation was found between the time spent every week participating in sports and glycated hemoglobin levels.

Adolescent↗
PubMed1990

[Neonatal hypocalcemia. Results of vitamin D supplement in the mother. Study on 13,377 newborn infants].

The incidence of hypocalcemia in newborn infant is greater in winter: 7.72% than in summer 2.63% if no vitamin D prophylaxis is given to the mother. After vitamin D supplementation, the incidence falls from 5.11 to 1.93%. This improvement occurs mainly in winter 7.72/2.43%. This last figure being equivalent in winter to the summer one above mentioned. Administration of a single dose (200,000 units vit D) at the end of pregnancy suppresses the seasonal handicap.

Female↗
PubMed1990

Comparison of two oral rehydration solutions in eutrophic infants with moderate acute diarrhea: results of an interim analysis.

A randomized, multicenter clinical trial comparing two oral rehydration solutions (ORS) with different sugar content and total osmolality was carried out in France. Solution A had 168 mmol/L of sugar and a total osmolarity of 326 mosm/kg; solution D had 90 mmol/L of sugar and a total osmolarity of 240 mosm/kg. Weight gain, stool output, and biologic variables were analyzed. This interim analysis included 49 infants (27 in group A and 22 in group D). Patients in both groups gained weight without any significant difference between the two ORS. Between admission and day 4, the overall number of stools and the number of liquid stools decreased. Laboratory values were within the normal range on admission and remained unchanged. The weight increase during the first 24 hours and the reduced frequency of stools was similar in both groups.

Acute Disease↗
PubMed1989

[Hypocalcemia in infants and children].

The hypocalcaemia observed in infants and children may have different causes, the most common being vitamin D deficiency rickets, which still exists, and hypoparathyroidism, which is rare. The clinical manifestations of hypocalcaemia may be neurological disorders, such as seizures, respiratory disorders with possible laryngospasm or severe cardiac disorders that may result in sudden death. Pronounced or symptomatic hypoglycaemia requires hospitalization and active therapy. Treatment has now been improved by the 1-hydroxyle derivatives of vitamin D.

Acute Disease↗
PubMed1989

Financial risk and hospital cost for elderly patients in non-age stratified urology DRGs.

The Diagnostic Related Group (DRG) hospital payment system may be inequitable for certain groups of Medicare patients. This study of 216 Medicare urology patients in the ten non-age stratified urology DRGs demonstrated that patients seventy years of age and older (70+) had higher resource consumption than patients under seventy years of age (70-). Findings were: (1) older patients (70+) had higher total hospital costs (+12,022 per patient) than younger patients (70-) (+9,872 per patient); (2) a longer hospital length of stay (14.2 days vs 11.6 days); (3) financial risk of +1,756 loss per (70+) patient vs +1,309 profit per (70-) patient (p less than 0.05); (4) more diagnoses and procedures per patient, and (5) a higher mortality (4.0% vs 3.3%). These findings suggest that the current DRG scheme may be inequitable vis-a-vis the older urology patient in non-age stratified DRGs, and thus could limit access and quality of care for these patients in the future.

Age Factors↗
PubMed1989

Postinfectious encephalitis with multifocal white matter lesions.

Two cases of multifocal white matter lesions occurring after viral illness are reported. Evoked potentials study and cranial magnetic resonance imaging (T2-weighted image) showed early abnormalities while CT scan was initially normal. Patients improved dramatically with steroid therapy. It would seem that because of a considerable responsiveness to steroids this affection should be differentiated from other types of encephalitis. Relations with multiple sclerosis are discussed.

Child↗