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Biomedical subjects

E Margaria

Publications and source records attributed to E Margaria.

At least 37 records · Page 2Linked to original sources
PubMed1983

Analgesic effect of peridural labetalol in the treatment of cancer pain.

Labetalol is an alpha- and beta-blocking agent commonly used in anti-hypertensive therapy. Because of its beta-blocking and local anesthetic effect, labetalol via peridural catheter was supposed to reduce pain in patients suffering from gynecologic cancers. Thirty patients with terminal carcinomas (breast, uterus, ovary), whose pain was caused either by bone metastases or by primary invasion cancer, were treated. Peridural catheters were inserted and fixed at various levels, thoracic or lumbar, and 50 mg labetalol was injected every 4 h at the beginning and every 12-24 h on the following 2-3 days. The analgesia started immediately during the injection. No sensitive damage or neurovegetative block appeared. In 40% of the patients the catheter was removed after a 3-day treatment because of the definitive suppression of pain. Other analgesics were not required during the treatment; no tolerance to the drug was developed. The peridural catheter remained in situ for an average period of 4-30 days. Afterward it was possible to treat more cases as outpatients depending on their general conditions and with the help of their family doctors. After a few days of therapy, almost all the patients reported a burning pain at the site of the injection; this problem was easily resolved by prior injection of a 4-mg dose of betamethasone.

Analgesics↗
PubMed1980

[Intensive postoperative treatment in obstetrics and gynecology: proposal for a score system for medico-surgical assessment of the abdominal surgery patient].

It is often necessary in routine clinical practice to take a decision on therapeutic conduct regarding patients with abdominal type postoperative complications. A score system has been devised which increases with the gravity of objective findings and the laboratory data most frequently observed in this pathology. The theoretical score is applied a posteriori to 12 serious cases of abdominal surgery. The values suggest an appropriate therapeutic approach: in effect, a score of less than 50 would point to wait-and-see medical treatment, not to be prolonged beyond 72 hours; values higher than 50 point to medical treatment preparatory to indispensable surgery.

Abdomen↗