Biomedical subjects

E Martínez Leandro

Publications and source records attributed to E Martínez Leandro.

4 recordsLinked to original sources

PubMed1996

[Study of the expression of proliferating cell nuclear antigen and p185 in non-small cell lung carcinoma].

We assessed immunohistochemical expression of p185 and the proliferating cell nuclear antigen (PCNA) in 68 patients undergoing surgery for non-small cell lung cancer. Adenocarcinoma of the lung was the histological type whose expression of p185 at levels exceeding 10% was greater to a statistically significant degree. Epidermoid carcinoma, on the other hand, was associated with the highest PCNA indices. Although these 2 markers had no prognostic value in the survival study, it must be pointed out that the longest survivors were patients with p185 expression less than 10% in neoplastic cells.

Adenocarcinoma↗

PubMedDate not supplied

[Moderately differentiated neuroendocrine carcinoma of the larynx].

We present a case of moderately differentiated neuroendocrine carcinoma of the larynx. These tumors represent 0.6% of all laryngeal carcinomas. Histological diagnosis requires the use of immunohistochemical methods, the tumoral cells presenting positivity for epithelial markers (cytokeratin) and neuroendocrine markers (chromogranin). Clinically, their location is supraglottic and they affect mainly males between the 6th-7th decades of life. The prognosis is better than that of squamous carcinoma or adenocarcinoma. The differential diagnosis must be made with granular cell tumor and paragangliomas.

Carcinoma, Neuroendocrine↗

PubMedDate not supplied

[Parotid tuberculosis].

Two rare cases of parotid gland tuberculosis are presented, which confirms the rising incidence of tuberculosis in Spain. Preoperative diagnosis is difficult, as the disease may be mistaken for a neoplastic process, and complementary tests, fine needle aspiration biopsy, CAT, analyses and chest X-rays are frequently nonspecific, particularly in the absence of a history of lung tuberculosis. As the diagnosis is histopathological, surgery in the form of a parotidectomy with preservation of the facial nerve is the treatment of choice, followed by 9 months of tuberculostatic medication. Only in cases in which the preoperative evidence (antecedents, chest X-rays) suggests the specific origin of the disease may antituberculosis treatment be given. Positive patient response is diagnostic.

Adult↗

PubMedDate not supplied

[Pseudosarcomatous lesions of the urinary bladder. Report of a case].

OBJECTIVE: The present study describes a case of pseudosarcomatous lesion of the urinary bladder, a rare disease entity that may occasionally be clinically mistaken for malignant neoplasms. METHODS/RESULTS: A 79-year-old male with hematuria who had previously undergone surgery is described. Cystoscopic examination revealed a tumor which was resected by TUR. The histological analysis disclosed a benign proliferative mesenchymal lesion comprised of spindle cells. CONCLUSIONS: Pseudosarcomatous lesions of the urinary bladder are benign lesions of fibroblastic or myofibroblastic origin that are more frequent in young adults and prevalent in females. Clinically they present with hematuria and treatment is by surgical excision (partial cystectomy or TUR). The prognosis is excellent.

Aged↗