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Biomedical subjects

E Mayzner-Zawadzka

Publications and source records attributed to E Mayzner-Zawadzka.

14 recordsLinked to original sources
PubMed2003

Perioperative use of recombinant activated factor VII in liver transplantation.

Recombinant activated factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S, Denmark) is a treatment used to prevent and arrest intra- and postoperative bleeds in patients with haemophilia A or B complicated by circulating anticoagulants (inhibitors of FVIII and FIX). Patients who qualify for liver transplantation may have varying degrees of coagulation impairment, which may adversely impact elective anaesthetic and surgical procedures and elevate the risk of intraoperative bleeds, which require massive blood transfusions and worsen prognosis. Recently, reports have been published on the use of rFVIIa prior to surgical procedures, which are likely to cause severe blood loss as well as for so-called emergency therapy of coagulation disorders during liver transplantation.

Adolescent↗
PubMed2002

Application of recombinant activated factor VII for treatment of impaired haemostasis during liver transplantation in recipients with Wilson's disease--a report of two cases.

Recombinant activated factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S, Denmark) is a treatment used to prevent and arrest intra- and postoperative bleeding in patients with haemophilia A or B complicated by circulating anticoagulants (inhibitors of FVIII and FIX) and in patients without haemophilia who spontaneously develop inhibitors of FVIII, i.e. in acquired haemophilia. Patients who qualify for liver transplantation due to liver dysfunction may have varying degrees of coagulation impairment and thus carry an elevated risk of massive bleeding and have worse prognosis. The authors administered recombinant activated factor VII to two patients with coagulation abnormalities in the course of Wilson's disease during liver transplantation.

Adolescent↗
PubMed1997

[Atypical use of continuous spinal anesthesia sets].

Continuous spinal anesthesia technique with portex sets was used for treatment of neuroinfection. The patients was 43 years old woman with meningitis caused by Cryptococcus sp. suffered from chronic kidney failure, after transplantation and graft removal because of it's rejection. Effectiveness of therapy confirmed high value of CSA not only for pain treatment, but for central nervous system diseases as well.

Adult↗
PubMed1984

Experimental porcine malignant hyperthermia: macromolecular characterization of muscle plasma membranes.

The purpose of this study was to examine muscle plasmalemma which is implicated as the site responsible for the appearance of malignant hyperthermia in human and susceptible strains of animals. In pigs with malignant hyperthermia (MH) the activity of Na+/K+, Mg2+-ATPase, p-nitrophenylphosphatase and Mg2+-ATPase fell significantly during anaesthesia. In the control group the contrary occurred. In both the groups tested there was a marginal rise in the levels of sialic acid. The levels of cholesterol and lysoderivatives were abnormal before the provoking agents were administered but they changed significantly after onset of the MH syndrome. Anaesthesia reduced the phospholipids level in both tested animal groups. Before and after the provoking agents an impoverishment in the polypeptide pattern in the range between 80,000 and 30,000 daltons of mol. wt. in MH susceptible animals occurred. It is postulated that in MH the macromolecular disorganization of the muscle plasma membranes means that defence mechanisms maintaining cell gradients do not work in the presence of provoking agents.

4-Nitrophenylphosphatase↗
PubMed1982

Experimental porcine malignant hyperthermia: the activity of certain transporting enzymes and myofibrillar calcium-binding protein content in the muscle fibre.

The activity of enzymes transporting calcium across the membrane of the muscle fibre and sarcoplasmic reticulum was studied. The activity of actomyosin Mg2+-ATPase and the composition of troponin were investigated also. In seven Pietrain pigs halothane alone or with suxamethonium induced the malignant hyperthermia syndrome. In the animals with malignant hyperthermia Ca2+-ATPase was not activated in the plasma membranes of the muscle fibres, when compared with control animals (n = 4). An increase of Ca2+-ATPase of the sarcoplasmic reticulum was observed in animals with malignant hyperthermia; the opposite was noted in the control group. No significant changes in the activity of Mg2+-ATPase of the sarcoplasmic reticulum and of Mg2+-ATPase of actomyosin were observed after exposure to halothane in control pigs and those with malignant hyperthermia. The amount of troponin C was significantly changed in the animals with malignant hyperthermia. The mechanism of the development of malignant hyperthermia syndrome is discussed.

Actomyosin↗
PubMedDate not supplied

[Clinical evaluation of hydroxy-ethylated starch (preparation HAES)].

Hydroxy-ethylated starch (HAES-Fresenius) has been evaluated clinically at the Department of Anesthesiology and Intensive Care, Medical Academy in Warsaw. This plasma substitute is used in several countries as plasma substitute similar to dextran but of better properties. Results of our studies have shown, that HAES is worth its opinion. It is quite good plasma substitute of favourable effect on tissue perfusion. The above features together with a wide therapeutical margin and the lack of any effect on blood coagulation place HAES over dextran plasma substitutes. This preparation should have wider use in Poland.

Evaluation Studies as Topic↗