Biomedical subjects

E Meys

Publications and source records attributed to E Meys.

8 recordsLinked to original sources

PubMed1994

[Osteoarticular complications of organ transplantations].

Osteoarticular complications can develop after organ transplantation and are responsible for high morbidity. In addition to infectious complications due to common or opportunistic germs, those that are the best known are complications related to glucocorticoid treatment, namely osteoporosis and epiphyseal osteonecrosis. More recently, other complications such as the effect of cyclosporine on bone metabolism and epiphyseal impaction have been observed. Still others are iatrogenic, due to the multiple drugs required following transplantation, and may affect the joints, the tendons or the musculature. Early detection and treatment of these complications play an important role in the quality of life of transplanted patients.

Humans↗

PubMed1994

Automated computerized radiogrammetry of the second metacarpal and its correlation with absorptiometry of the forearm and spine.

The value of a new computerized radiogrammetric method of assessment of the second metacarpal has been evaluated, and its results have been compared with those of single (SPA) and dual photon absorptiometry measurements (forearm and spine) in 74 and 79 postmenopausal women, respectively. Standard hand X-rays were digitized by a video-camera connected to a microcomputer. The combined cortical thickness (CCT) was automatically calculated in a zone of 10 mm around the midpart of the second metacarpal. The intra- and interobserver coefficients of variation were close to 1%. The correlation between CCT and SPA of the proximal and midforearm (with a significant amount of cortical bone) was satisfactory (r = 0.62 and 0.50, respectively; P < 0.001). The correlation between CCT and osteodensitometry of sites comprising more trabecular bone were not so good (0.50 for lumbar and 0.44 for distal forearm bone mineral density, respectively), but still significant (P < 0.001). Radiogrammetry proved unaffected by a change of X-ray apparatus, as measurements of 48 metacarpals radiographed by two different kinds of X-ray apparatus were not significantly different. Radiogrammetry is by no means the best method to evaluate bone mass. Its automation did not improve the correlation with osteodensitometric values. Radiogrammetry is still of interest in mass screening, particularly when other more expensive techniques such as osteodensitometric methods of bone mass measurement are not readily available. Its automation makes it simpler, faster, and more precise, rendering its use easier on a larger scale.

Absorptiometry, Photon↗

PubMed1994

Bone loss after orthotopic liver transplantation.

PURPOSE: We assessed changes in body composition and bone loss following liver transplantation to determine if bone loss is related to the underlying liver disease or to other factors such as sex, menopause, or graft rejection episodes. PATIENTS AND METHODS: Our cross-sectional study component compared bone mass and body composition in 31 patients at 1 year after liver transplantation versus 33 pregraft patients with chronic liver disease. Bone mass was measured by dual energy X-ray absorptiometry (DXA) using anteroposterior views of the total body to determine bone mineral content (BMC), and of the lumbar spine to assess bone mineral density (BMD). The body fat content was also determined by DXA. Radiographs of the thoracic and lumbar spine were also obtained. In our longitudinal study component, 16 patients from the pregraft group underwent bone mass assessment again 1 year after transplantation. RESULTS: Graft patients and pregraft patients both had reduced lumbar spine BMD compared to age- and sex-matched normal values (P < 0.001). A 4.75% increase in body fat content was observed after liver transplantation (P < 0.05). In the cross sectional study, bone mass of the spine and total body were not different in pre- and posttransplantation patients. However, the longitudinal study revealed significant decreases in spinal BMD and total body BMC, with a mean 3.5% decrease and a rate of loss of 0.55% per month. In addition, a dramatically high prevalence (29%) of vertebral fractures was observed in grafted patients, contrasting with a low prevalence (8.4%) of fractures in pregraft patients. Menopause, primary biliary cirrhosis, and chronic alcohol abuse were the principal contributing factors for osteoporosis. Patients with vertebral fractures had a marked 17.4% decrease of the lumbar spine BMD (P < 0.001) and a 22% decrease in total BMC when compared to patients without fractures (P < 0.01). CONCLUSION: Patients with orthotopic liver transplantation for chronic liver disease evaluated 1 year after transplantation have a high prevalence of vertebral fractures. Cross sectionally, bone mass was not different in patients before and after transplantation, but the longitudinal study showed that liver transplantation induced a marked and rapid bone loss. Bone loss due to transplantation could enhance the risk of new vertebral fractures, as shown by the high prevalence of vertebral fractures. These results emphasize the need to identify patients with low bone mass by bone densitometry before transplantation.

Absorptiometry, Photon↗

PubMed1993

Bone loss after cardiac transplantation: effects of calcium, calcidiol and monofluorophosphate.

Of 203 patients who underwent cardiac transplantation and were given long-term treatment with cyclosporine and 0.3 mg/kg per day prednisone, 123 were studied prospectively for at least 6 months and 46 for up to 2 years to evaluate the effects on lumbar bone mineral density (BMD) and calcium metabolism of a combined therapy with calcium, calcidiol and disodium monofluorophosphate (MFP). The population was arbitrarily assigned to one of two groups. Group I consisted of patients who had a lumbar spine BMD Z score above -1.5 SD as compared with an age- and sex-matched population and no vertebral fractures. They received daily 1 g elemental calcium and 25 micrograms (1000 IU) calcidiol. Group II consisted of patients who received daily the same doses of calcium and calcidiol combined with 200 mg MFP, and was divided into two subgroups: (a) osteopenic subjects who had a lumbar spine BMD Z score below -1.5 SD without vertebral fractures and (b) osteoporotic subjects with vertebral fractures. If serum creatinine was higher than 140 mumol/l the daily dose of MFP was tapered to 100 mg. Fifty-four and 27 patients from group I and 38 and 19 patients from group II were followed respectively for 12 and 24 months. In both groups serum parathyroid hormone levels were significantly reduced from the twelfth month in parallel with a significant increase in serum 25-OHD levels. No decline in lumbar BMD occurred in non-osteopenic and non-osteoporotic patients (group 1) who received the calcium and calcidiol supplement. In group II, where MFP was added, a significant and linear increase in lumbar BMD was observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1992

Septic Streptococcus milleri prepatellar bursitis.

The osteoarticular affinity of Streptococcus milleri has only recently been recognized. We report a case of septic prepatellar bursitis caused by this pathogen. The recent literature concerning osteoarticular involvement by S. milleri is reviewed.

Bursitis↗

PubMed1992

Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity.

We describe a patient with rheumatoid arthritis (RA) who developed hypersensitivity after 3 weeks of therapy with azathioprine with fever, jaundice and renal insufficiency. A percutaneous liver biopsy was compatible with hypersensitivity hepatitis. During azathioprine rechallenge, the symptoms recurred within a few days, consistent with the diagnosis of an acute hypersensitivity reaction. This report is the first to describe the association of an azathioprine induced hypersensitivity simultaneously involving the liver and the kidneys, in the same patient with RA, with resurgence after rechallenge.

Acute Disease↗

PubMed1991

[Role of iatrogenic spondylodiscitis among pyogenic spondylodiscitis. 136 cases observed between 1980 and 1989].

The authors report 136 cases of spondylodiscitis due to ordinary organisms seen between 1980 and 1989 and note the increasing incidence of iatrogenic forms which during the past three years accounted for 50 per cent of cases. 60 per cent of these cases of iatrogenic spondylodiscitis complicated a medical of surgical procedure involving the spine (form by direct inoculation). In 40 per cent of cases, the organism came from a site of infection located at a distance (from by blood-borne spread). The clinical picture in cases of primary spondylodiscitis and of iatrogenic disease by blood-borne spread is essentially similar. That of iatrogenic forms by direct inoculation is different: most often young subjects, virtually exclusive involvement of the lumbar spine, fever and inflammatory syndrome less common. Escherichia coli and Staphylococcus aureus were the organisms most often responsible for primary spondylodiscitis (23 and 21.7 per cent of case respectively). Streptococci were in third position only (15.6 per cent of cases). Staphylococcus aureus remained predominant in iatrogenic spondylodiscitis (34 per cent of cases), while Escherichia coli and streptococci were significantly rarer than in primary forms and there was the appearance of Pseudomonas aeruginosa and Staphylococcus albus. No organism was found in 23 per cent of cases of primary spondylodiscitis. This figure reached 44% of iatrogenic forms by direct inoculation. Because of their increasing incidence, these cases of apparently aseptic spondylodiscitis, frequently complicating a procedure involving the spine, are modifying the picture of infectious spondylodiscitis. No doubt worthy of separate identification, they raise the problem of the significance of the concept of aseptic spondylodiscitis.

Adolescent↗

PubMed1991

[Severe hypertriglyceridemia and acute pancreatitis in pregnancy. A case report].

We report the case of a 32-year old woman who developed major hypertriglyceridaemia complicated by acute pancreatitis at 35 weeks of pregnancy. Caesarean section was performed within 24 hours of admission. After delivery, hypocaloric parenteral feeding without lipid emulsion was initiated. The outcome was favourable, and the patient could resume oral feeding after 5 weeks. The incidence of pancreatitis during pregnancy is 1 in 1,000 to 3,000 pregnancies. In the identification of the metabolic abnormality in our patient the differential diagnosis was between type III and type IV hyperlipaemia, according to Fredrickson's classification.

Acute Disease↗