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E Michalodimitrakis

Publications and source records attributed to E Michalodimitrakis.

11 recordsLinked to original sources
PubMed2006

Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner.

Corticotropin-releasing factor (CRF) affects catecholamine production both centrally and peripherally. The aim of the present work was to examine the presence of CRF, its related peptides, and their receptors in the medulla of human and rat adrenals and their direct effect on catecholamine synthesis and secretion. CRF, urocortin I (UCN1), urocortin II (UCN2), and CRF receptor type 1 (CRF1) and 2 (CRF2) were present in human and rat adrenal medulla as well as the PC12 pheochromocytoma cells by immunocytochemistry, immunofluorescence, and RT-PCR. Exposure of dispersed human and rat adrenal chromaffin cells to CRF1 receptor agonists induced catecholamine secretion in a dose-dependent manner, an effect peaking at 30 min, whereas CRF2 receptor agonists suppressed catecholamine secretion. The respective effects were blocked by CRF1 and CRF2 antagonists. CRF peptides affected catecholamine secretion via changes of subplasmaliminal actin filament polymerization. CRF peptides also affected catecholamine synthesis. In rat chromaffin and PC12 cells, CRF1 and CRF2 agonists induced catecholamine synthesis via tyrosine hydroxylase. However, in human chromaffin cells, activation of CRF1 receptors induced tyrosine hydroxylase, whereas activation of CRF2 suppressed it. In conclusion, it appears that a complex intraadrenal CRF-UCN/CRF-receptor system exists in both human and rat adrenals controlling catecholamine secretion and synthesis.

Adrenal Glands↗
PubMed2006

The British Abortion Act (1967) and the interests of the foetus.

This article examines ethical issues on the rights and interests of the unborn foetus, an issue that remains highly contentious. Furthermore, it attempts to investigate how well the British legislation fits with the foetus and pregnant woman's rights and interests. "Pro-life" and "pro-choice" groups have provided extensive arguments for and against. One important theoretical issue rests on whether foetuses are human beings in the moral sense, in which all human beings have full and equal moral rights. What constitutes personhood is a matter of moral decision and is not one of scientific fact and thus it consists of all persons, rather than all genetically human entities. It is persons who invent moral rights and who are capable of respecting them. Legislators in Britain have sidestepped the ethical debate on abortion by opting for the pragmatic course of permitting abortion in a limited range of circumstances and thus the Abortion Act 1967 has failed to address the status of the foetus, or indeed the rights of any of the parties concerned. Thus, although the Act supports the interests of the foetus capable of free existence by lowering the foetal age to 24 weeks after which termination is not permissible, the legislators have accepted that the rights of the woman outweigh those of the foetus and if a woman's own life or health is in danger then even a late abortion is the best choice.

Abortion, Legal↗
PubMed2005

Forensic pathology--de profundis.

This review of the literature discusses the evolution of the professional role of the forensic pathologist. This role is defined as that of an expert who mainly assists the legal process of investigating suspicious or unexpected deaths. The forensic pathologist is independent, bringing his expertise to various parts of the judicial process. His role in the development of forensic investigation and promotion of human rights is important.

Criminology↗
PubMed2004

Organ and tissue transplantation in Greece: the law and an insight into the social context.

Advances in biological sciences and medicine have revolutionized current practice and opened new horizons. Tissue and organ transplantation is a miracle and an action of love and sacrifice for the sake of fellow human beings. Organ transplantation has been commonplace over the last decade but Greece still remains the lowest numerically among European countries in this field because of the lack of organ donation although it is highest in traffic accidents. Despite this, the legal framework regulating transplantation was enacted late in comparison to other European countries, and was not the only obstacle to the development of organ donation. Several other factors such as philosophy, culture, traditional and religious attitudes, lack of public information and lack of the relevant social fabric, have all contributed to the current sad situation. This article aims to present a critical view on the evolution of the legal framework in the field of tissue and organ transplantation in Greece. Issues that still deter organ donation are discussed along with an insight into the current situation in the Greek social context in order to make a constructive contribution to future perspectives.

Greece↗
PubMed2002

The importance of communication between physicians and patients. Special considerations in the era of endovascular therapy.

Most of the lawsuits in medical practice are the result of inadequate communication between doctors and patients and litigation has very little to do with errors. In the era of the technological development and the implementation of new techniques such as endovascular therapy, good communication between physicians and patients is essential. The purpose of this review is to elicit important considerations on challenging issues relating to the art of communication between physicians and patients and to provide information on what the vascular surgeon or interventionalist should bear in mind in obtaining an adequate informed consent from the patients.

Communication↗
PubMed2001

Prevalence of polyps and diverticulosis of the large bowel in the Cretan population. An autopsy study.

While a number of studies have been performed in the United States, northern Europe, and some other countries on the epidemiology of large bowel polyps and diverticulosis, information from southern Europe and especially Greece is very limited. Our autopsy study sought to determine the prevalence of large bowel polyps and diverticulosis in the population on Crete. Specimens of colon and rectum were obtained during forensic postmortem autopsies and examined for the presence of polypoid lesions and diverticulosis. Data were collected from a total of 502 autopsies (320 men, 182 women; median age 65 years (range 16-93). Polyps were found in 106 cases (21.1%). These were adenomas in 73 cases (14.5%), hyperplastic polyps in 25 (4.9%), and mucosal tags in 8 (1.5%). Diverticulosis of the large bowel was found in 115 (22.9%). The prevalence of adenomas and diverticulosis increased with advanced age. The prevalence of colonic diverticulosis in Crete is slightly lower than that which has been reported in most other studies in economically developed countries. The prevalence of colorectal adenomas in Crete is one of the lowest rates reported in Europe and is compatible to the known low incidence of colorectal cancer in Crete.

Adenoma↗
PubMed2000

Patterns of male-specific inter-population divergence in Europe, West Asia and North Africa.

We typed 1801 males from 55 locations for the Y-specific binary markers YAP, DYZ3, SRY10831 and the (CA)n microsatellites YCAII and DYS413. Phylogenetic relationships of chromosomes with the same binary haplotype were condensed in seven large one-step networks, which accounted for 95% of all chromosomes. Their coalescence ages were estimated based on microsatellite diversity. The three largest and oldest networks undergo sharp frequency changes in three areas. The more recent network 3.1A clearly discriminates between Western and Eastern European populations. Pairwise Fst showed an overall increment with increasing geographic distance but with a slope greatly reduced when compared to previous reports. By sectioning the entire data set according to geographic and linguistic criteria, we found higher Fst-on-distance slopes within Europe than in West Asia or across the two continents.

Africa, Northern↗
PubMed1999

The position of the axillary nerve in the deltoid muscle. A cadaveric study.

In 134 deltoid preparations taken from 67 fresh cadavers we examined the position of the axillary nerve in relation to the upper border of the muscle. The vertical distances from the upper deltoid border to the nerve in 17 of 67 cadavers was less than 4 cm in both shoulders. The minimal distance, measured from the mid-middle portion of the deltoid to the axillary nerve, was 2 cm. There was a significant negative correlation between the deltoid ratio (width/length) and the vertical distance, measured in all examined sites. The shorter the deltoid length the greater the danger of damaging the nerve in the short distance during surgical splitting of the muscle.

Adolescent↗
PubMed1987

Nitrogen narcosis and alcohol consumption--a scuba diving fatality.

Nitrogen narcosis can cause death among experienced scuba divers. Nitrogen under pressure affects the brain by acting as an anesthetic agent. Furthermore, the consumption of ethanol along with diving will cause the symptoms of nitrogen narcosis to occur at depths less than 30 m. Our case deals with an experienced diver who drank alcoholic beverages before diving and developed symptoms of nitrogen narcosis at a shallow depth. These two conditions contributed to his death by drowning.

Adult↗