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Biomedical subjects

E Michels

Publications and source records attributed to E Michels.

10 recordsLinked to original sources
PubMed1991

Use of the t test.

Explore the source record for details and available documents.

Analysis of Variance↗
PubMed1987

Murine alpha-2-macroglobulin: localization on a subpopulation of macrophages.

We have previously shown that mouse peritoneal macrophages synthesize and secrete alpha-2-macroglobulin (alpha 2M) in culture. We have now examined whether alpha 2M delineates a subpopulation of murine macrophages. Mouse alpha 2M was purified from plasma by gel filtration and immunoabsorption to remove IgM. Purified alpha 2M was an active proteinase inhibitor, had a pI of 4.8, and a relative molecular mass (Mr) of 765 kD which dropped to 194 kD on reduction. Antisera raised against mouse alpha 2M were not cross-reactive with guinea pig or human alpha 2M, or with antigens in guinea pig, human, bovine or equine serum. One to 18 per cent of freshly isolated bone marrow, resident peritoneal or induced peritoneal macrophages displayed immunoreactive cytoplasmic and surface alpha 2M as detected by single cell immunoperoxidase assay or flow cytometry. alpha 2M was not detected in or on thymocytes or bone marrow lymphocytes. In culture, bone marrow-derived macrophages displayed peak levels of cytoplasmic alpha 2M on day 7 and two peaks of surface alpha 2M on days 2-3 and 5-7. The fact that alpha 2M can function as an anti-proteinase, can modulate lymphokine production and is present on inflammatory macrophages suggests a regulatory role for macrophages bearing and secreting this molecule at tissue sites of inflammation.

Animals↗
PubMed1976

Research and human rights. Part 1.

The problem of biomedical research and human rights is reviewed from the perspectives of current issues, historical events, and other sciences. Government control of research, reactions to and possible consequences of that control, and the concern for consent from members of vulnerable populations are examined. The nature of research is discussed and the origins of opposing ethical views are described in an attempt to clarify the issues within the problem.

Animals↗
PubMed1976

Guidelines for meetings.

The major purpose of a meeting is to make decisions. The most basic and important elements of conducting a meeting, preparing motions for consideration, and recording the decisions are presented. The use of the guidelines for more or less formal meetings is discussed.

Congresses as Topic↗
PubMed1975

On becoming a confederation.

This paper was presented as the keynote speech at the Seventh International Congress of the World Confederation for Physical Therapy. The question of what it will take to strengthen physical therapy as a world force for the health of mankind is examined. The past and present status of physical therapy and the Confederation are assessed as background for looking at ways to help the Confederation become truly a World Confederation for Physical Therapy.

History, 20th Century↗