Biomedical subjects
Publications and source records attributed to E Mineva.
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Immune electron microscopy (IEM) was employed in studying faecal samples of viral hepatitis type A patients and their contacts, in whom the presence of an antigen, differing from the HBsAg, designated as Botevgrad antigen (BA) was proved by the CFT. Particles 25--28 nm in diameter, aggregated by sera positive for the anti-HAAg were established in the faecal samples. The buoyant density of these particles in CsCl was found to be 1.40 g/ml. Particles of the same buoyant density were established also in sera positive for BA which were aggregated in large masses with antiserum against BA obtained from rabbits. The associations between BA and HAAg are discussed.
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The development of cell-mediated immunity (CMI) to the surface antigen of hepatitis B virus (HBSAg) and Botevgrad antigen (BA) was traced in 50 hepatitis patients. Migration inhibition test (MIT) was performed with purified HBSg and AB. Blood samples from every hepatitis patient were obtained at the beginning of the icteric phase, 10 days later and during convalescence. There was correlation between the two types of viral hepatitis and the type of cellular immune response. The development of CMI is associated with disappearance of HBSAg from the serum of hepatitis patients. CMI to HBSAg develops within 9-12 days after the onset of icterus and to BA during the first two days of icterus. There is a relationship between the persistence of HBSAg and CMI.
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