Biomedical subjects

E Morishige

Publications and source records attributed to E Morishige.

3 recordsLinked to original sources

PubMed2006

Occlusal interference during mastication can cause pathological tooth mobility.

BACKGROUND AND OBJECTIVE: Despite little evidence regarding the relationship between tooth mobility and nonworking contact, the evaluation of occlusion is performed mainly by the detection of premature and/or nonworking contacts during tapping movements and lateral excursion. The hypothesis of this study is that occlusal contact during mastication is potentially traumatic to periodontal tissue. It clarifies the relationship between chewing patterns and the status of periodontal tissue. MATERIAL AND METHODS: Subjects included 73 adults, 20-29 years of age (39 men and 34 women), with complete sets of teeth and no history of orthodontic treatment or periodontal disease. The closing chewing patterns of each subject were classified into three groups by the Masticatory Deviation Index, which depicts the deviation from the normal chewing patterns within 5 mm from the intercuspal position. Periotest was used to diagnose teeth mobility and the values were compared among the three groups. RESULTS: The present study indicates that the chewing movements which deviated from the normal chewing movements increased the mobility of specific types of teeth. CONCLUSION: The results of this study imply a relationship between chewing movements and tooth mobility and indicate that functional evaluation of occlusion is necessary for the examination of periodontal tissue. Occlusal evaluation with border and tapping movements might be insufficient, and functional occlusal evaluation during chewing movements can be clinically useful for using to evaluate periodontal tissue.

Adult↗

PubMed1980

[Comparative studies on the hemodynamic effects of dobutamine, dopamine, and isoproterenol in dogs in experimental shock (author's transl)].

Cardiovascular effects of dobutamine (DOB), isoproterenol (Iso), and dopamine (DA) were compared in Beagle dogs weighing 6.8 to 11.6 kg under experimental shock produced by ligation of the left coronary arteries and intravenous administration of hexamethonium-Br (10 mg/kg). Intravenous infusion of DOB (1 approximately 20 microgram/kg/min) dose-dependently improved the hemodynamic state of shock by increasing left ventricular dp/dt (LV dp/dt), cardiac output (CO), and blood pressure. These improvements were also observed with the infusion of DA (20 approximately 40 microgram/kg/min). However, the improvement with Iso (0.01 approximately 0.2 microgram/kg/min) was incomplete because of the marked fall of total peripheral resistance. Both DOB and DA increased the venous return, pressure in the inferior vanae cavae, and pressure difference between venous pressure and left ventricular end diastolic pressure. It was presumed that these effects were related to the stimulation of the alpha receptor in the venous system, in addition to the marked positive inotropic effects by DOB or DA. Iso increased significantly only the venous return. Although increases of coronary flow with DOB and DA are probably mainly due to an increase of myocardial oxygen consumption, the increase of coronary perfusion pressure also may contribute to the increase of coronary flow. As a result, myocardial oxygen balance was improved with DOB or DA. alpha stimulation in the venous system as well as beta 1 stimulation apparently contributes to improvement of the deteriorated hemodynamic state, in experimental shock, as induced in dogs.

Animals↗

PubMed1977

[Comparative study between dobutamine and other catecholamines in their effects on the cardiac contraction and rhythm (author's transl)].

Dobutamine (DOB) showed a dose dependent positive introphic effect on the right ventricular muscle of vagotomized Beagle dogs under pentobarbital anesthesia. Positve inotropic effects of other catecholamines (CA) decreased in the following order; isoproterenol (Iso, 115) greater than norepinephrine (NE, 15) greater than DOB (1) greater than dopamine (DA, 0.36). Brachiocephalic arterial flow was also increased by DOB with a positive inotropic effect in the right ventricular muscle. Though the positive inotropic effect of DOB was slightly decreased by pretreatment with phenoxybenzamine, such was almost completely antagonized by propranolol. Contractions of isolated cat papillary muscle driven by electrical stimulation (12 beats/min) were increased by CA in the following order; Iso (17) greater than NE (3) greater than epinephrine (2.5) greater than DOB (1) greater than DA (1 greater than). Activity of DOB to induce spontaneous contractions of papillary muscle was weakest among these CA. To determine the arrhythmogenic effect of these CA, coronary ligated Beagle dogs were employed, in which the anterior descending branch of the left coronary artery was ligated. Arrhythmogenic activity of DOB was weaker than other CA employed both in early stages and 48 hr after coronary ligation. DOB shows good potential for treating acute cardiac insufficiency and cardiogenic shock, as effects on heart rate and blood pressure are weaker.

Adrenergic alpha-Antagonists↗