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Biomedical subjects

E Mulagha

Publications and source records attributed to E Mulagha.

2 recordsLinked to original sources

Extracorporeal shock wave lithotripsy of gallstones revisited: current status and future promises.

The improvement and refinement of extracorporeal shock wave lithotripsy (ESWL) has made this non-invasive treatment modality not only more effective, but also applicable to a larger population of gallstone patients. It can be performed safely on an outpatient basis. Advances in lithotripsy technology have made it possible to fragment stones into very small, sand-like particles (pulverization), which clear the gall-bladder faster than large fragments. Recent studies provide evidence that adjuvant bile acids may not be necessary in most cases in which pulverization is achieved. Good gall-bladder emptying appears both to promote the clearance of gallstones after ESWL and to decrease their recurrence. Although generally found to be more expensive than surgery if bile acids are used, ESWL should be cost-effective, as bile acids may not be necessary in all patients. Elderly patients with radiolucent, solitary and less than 30 mm gallstones can particularly benefit from lithotripsy.

Ambulatory Care↗

Acute Cholecystitis.

Patients with a diagnosis of acute cholecystitis need to be hospitalized, with surgery (ie, cholecystectomy) being the treatment of choice. While hospitalized, they should be treated with intravenous hydration and with intravenous antibiotics covering enteric organisms. They should receive nothing by mouth and may require a nasogastric tube if ileus is present. The use of such conservative management for 24 to 48 hours allows the inflammatory and infectious processes to "cool down." Early surgery performed right after this initial period of conservative therapy is preferred over delayed surgical management (ie, discharge of the patient and readmission for the surgery 6 to 8 weeks later). Several studies have shown that early cholecystectomy not only has no adverse effects on complication rates but also leads to shorter hospital stays and quicker return to productivity. Laparoscopic cholecystectomy is the preferred operation because it is associated with a shorter hospital stay, less pain, and earlier return to productivity than is open cholecystectomy. There is an increase in the frequency of bile duct injury with this procedure, however. In patients who are poor surgical candidates, cholecystostomy can be performed via percutaneous catheter drainage of the gallbladder with the patient under local anesthesia. In addition, endoscopic transpapillary drainage with or without gallstone dissolution (methyl tert-butyl ether ) has been demonstrated to be an effective alternative to surgery in high-risk patients with acute calculous cholecystitis.

Journal Article↗