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Biomedical subjects

E Mullins

Publications and source records attributed to E Mullins.

7 recordsLinked to original sources
PubMed1996

Are hydrogen breath tests valid in the elderly?

Hydrogen breath testing (HBT) is frequently used as an alternative to small bowel aspiration in the diagnosis of small intestinal bacterial overgrowth (SIBO). The role of the glucose HBT was assessed in 30 elderly patients. A positive HBT was recorded in 15 of 20 SIBO cases and 7 of 10 culture negatives (sensitivity 75% and specificity 30%). The correlation coefficients between hydrogen gas (H2) rise and total bacterial count (r = 0.21) and H2 rise and anaerobic count (r = 0) were not significant. Fasting H2 levels were raised in only 4 of the 20 SIBO cases. This study indicates that the HBT is not reliable in the diagnosis of SIBO in the elderly. There was no evidence from the data that different H2 levels or bacterial counts would significantly alter the reliability of the HBT. This work suggests that factors other than small bowel bacteria are involved in the production and expiration of H2 in the elderly, and that these factors need to be considered in the interpretation of this breath test.

Aged↗
PubMed1994

Small intestinal bacterial overgrowth--an incidental finding?

OBJECTIVES: To assess the prevalence of typical clinical features and need for treatment of small intestinal bacterial overgrowth (SIBO) in the elderly. DESIGN: Random selection of patients, regardless of their nutritional status. SETTING: Acute admissions ward in the Dept. of Medicine for the Elderly. PATIENTS: Thirty elderly patients between 68 and 90 years of age. MEASUREMENTS: Active clinical problems, including the presence of recent weight loss and diarrhea, were recorded. Routine blood tests, including serum vitamin B12, red cell folate, albumin and calcium, and qualitative small bowel bacteriology results, were analyzed. The effect of age on all variables was studied. RESULTS: Twenty of the 30 small bowel aspirates had proven SIBO, and strict anaerobes were isolated in 15. The mean blood test values did not differ significantly between culture-positive and culture-negative patients. There was no significant correlation between those variables and the total bacterial counts. Of the 20 proven SIBO cases, eight had anemia, five had hypoalbuminemia, five had diarrhea, four complained of recent weight loss, and none had B12 deficiency. Alternative causes other than SIBO were identified for many of these abnormalities. Advancing age correlated significantly with rising counts of small bowel strict anaerobes. CONCLUSIONS: These data suggest that age may be a predisposing factor in the development of anaerobic overgrowth but that SIBO is a benign entity in the elderly. Contrary to previous recommendations, treatment of this condition is not routinely indicated.

Age Factors↗
PubMed1991

Relationship between kennel size and stress in greyhounds transported short distances by air.

Greyhounds are usually transported by air between Ireland and England in wooden kennels similar in size to greyhound racing starting traps. These kennels have been criticised in the belief that their small size leads to unnecessary stress. The present study compared plasma ACTH, cortisol, lactate and non-esterified fatty acid concentrations in 12 greyhounds transported either in the existing wooden kennels or in wider perspex kennels, which were stowed either in the belly hold or in the main cargo hold of jet freighter aircraft. Increased kennel size did not appear to result in decreased stress responses but there was a significantly greater stress response in the dogs kept in the belly hold of the aircraft. Individual variation between dogs was the most significant feature of the study.

Aircraft↗
PubMed1983

Natural background radiation and cancer mortality in the Republic of Ireland.

An extensive area of rural Ireland was monitored in detail for natural background radiation (NBR); average background radiation values were derived for all District Electoral Divisions (DEDs) in this area. Cancer mortality rates were calculated for the DEDs aggregated according to average NBR. No association was apparent between cancer mortality rates and levels of natural background radiation.

Background Radiation↗
PubMed1982

On the analysis of studies of choice.

In a review of 103 sets of data from 23 different studies of choice, Baum (1979) concluded that whereas undermatching was most commonly observed for responses, the time measure generally conformed to the matching relation. A reexamination of the evidence presented by Baum concludes that undermatching is the most commonly observed finding for both measures. Use of the coefficient of determination by both Baum (1979) and de Villiers (1977) for assessing when matching occurs is criticized on statistical grounds. An alternative to the loss-in-predictability criterion used by Baum (1979) is proposed. This alternative statistic has a simple operational meaning and is related to the usual F-ratio test. It can therefore be used as a formal test of the hypothesis that matching occurs. Baum (1979) also suggests that slope values of between .90 and 1.11 can be considered good approximations to matching. It is argued that the establishment of a fixed interval as a criterion for determining when matching occurs, is inappropriate. A confidence interval based on the data from any given experiment is suggested as a more useful method of assessment.

Journal Article↗