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Biomedical subjects

E Muti

Publications and source records attributed to E Muti.

17 recordsLinked to original sources
PubMed2005

The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases.

Abnormal increments of pro-inflammatory cytokines (IL-6 and TNF-alpha) characterize the outbreak of infectious diseases, which are the major cause of death in the elderly. A counterbalance to the inflammation is exerted by IL-10 with an inhibitory role on TNF-alpha production. As is well known, some cytokine gene polymorphisms influence the cytokine production, playing a role as susceptibility or resistance factors against immune-mediated and infectious disease. Genetic variations in the -308A/G locus for TNF-alpha seems to affect the clinical outcome of some infectious diseases. In fact, the -308A allele is associated with severe septic shock and death. On this basis, we have screened healthy old subjects, nonagenarians and old patients affected by the acute phase of chronic obstructive bronchitis and bronchopneumonia of bacteria origin for the -308G/A locus (PCR-RFLP). Subjects are grouped in A+ (AG, AA genotypes) and A- (GG genotype) and data on IL-6, TNF-alpha, IL-10, NK cell cytotoxicity, zinc and metallothioneins (MTs) gene expression (RT-PCR) were stratified according to different TNF-alpha genotypes. The frequency of the A allele was increased in infected patients in comparison with healthy old controls. No differences existed between A+ and A- young adult, old and nonagenarian controls in tested parameters. Conversely, A+-infected patients displayed elevated IL-6, TNF-alpha and MTmRNA, low IL-10 coupled with impaired NK cell cytotoxicity and lower zinc ion than A- patients. However, the data reported are gender independent. Therefore, the -308A polymorphism at the locus of TNF-alpha may be one of the susceptibility factor for infectious diseases in old persons, particularly considering its association to the increased release of pro-inflammatory cytokines and to the reduction of zinc release and MTs synthesis involved in the control of the inflammatory response. These data strongly suggest that the genetic screening of the -308G/A polymorphism may be a valid tool for identification of subjects needing a more appropriate therapy when affected by acute and/or recurrent infectious diseases.

Adult↗
PubMed1993

Treatment of alar cartilages: should the "domes" be interrupted?

The author emphasizes that conservative rhinoplasty techniques are frequently satisfactory, but in certain techniques there is a limit to which nasal tips can be reshaped. In certain circumstances, therefore, interruption of the "domes" of the alar cartilages is suggested to achieve the most satisfactory aesthetic results.

Cartilage↗
PubMed1992

Modifications in the psychological and behavioural structure of women after mastectomy.

The authors report a psychological equiry carried out by interviews and tests on mastectomised patients to find out the psycho-effective and behavioural implications related to this type of mutilation, to the type of preoperative information and to the relation with the doctor in charge, also to an eventual morphological reconstruction of the breast. They also analyse the relation between the objective result evaluated by the surgeon and the subjective evaluation of the patient. Some results of breast reconstruction are presented.

Adult↗
PubMed1991

Cartilage chips synthesized with fibrin glue in rhinoplasty.

A new type of cartilage graft that is synthesized from cartilage fragments minced by our instrument and mixed with fibrin glue is described. This new material is useful when particular grafts are required in primary or secondary rhinoplasty.

Cartilage↗
PubMed1983

The nasofrontal angle and profile in rhinoplasty: case presentations.

Current anthropometric measurements establish the nasofrontal angle. However, it is unwise to establish the lines and equilibrium of volumes of the face within fixed geometrical parameters. Even the data given by various forms of rhinometers do no seem to be suitable since they do not take into account the inclination and curvature of the forehead. The authors thus prefer to study the individual to be treated within a program of harmonization of the three areas of the face, the upper, middle, and lower thirds. The results of treatment utilizing this concept are depicted.

Anthropometry↗
PubMed1983

Cryotherapy in the treatment of keloids.

A brief account of the clinical and histological features of keloids, their differentiation from hypertrophic scars, their etiopathogenesis, and the various methods for their treatment is followed by an assessment of the possibilities offered by cryotherapy and its advantages and drawbacks. Reference is made by way of illustration to 4 patients chosen from a series of more than 100 on the basis of the importance of their clinical pictures. The conclusion is drawn that cryotherapy with nitrogen protoxide is both useful and practical in the management of carefully selected cases and deserves fuller understanding and more widespread employment than it enjoys at present.

Adolescent↗
PubMed1975

[Treatment of tumors of some structures of the splanchocranium].

The results of long experience with many methods of reconstructive surgery following destruction of various splanchnocranial structures are presented. Emphasis is placed on the usefulness of cooperation between the oncological and plastic surgeon. Fifteen cases are illustrated. In many of these, endoarterial infusion of chemical antiblastics was first employed. Since tumours may vary considerably in site and histological type, as well in the biotype, age and sex of the patient, and since a variety of radical and reconstructive techniques exist for individual or associated use, therapeutical programmes cannot be put forward with any degree of confidence, but must obviously be determined by the surgeon's personal experience.

Adult↗
PubMedDate not supplied

Surgery of the naso-frontal angle.

The naso-frontal angle is one of the features that most markedly determines the morphology of the human face. Two main morphological elements must be taken into consideration: the slope of the forehead and the line of nasal dorsum. For a balanced physiognomy, nevertheless, it is necessary to achieve a correct interaction of the length and width of nasal pyramid, the naso-labial angle, and the chin. Closer examination of the naso-frontal angle shows that a cranial or caudal shift in its position affects the length of the dorsum; however, the fundamental aspect characterizing the naso-frontal angle is its width: it may be normal, too wide, or too narrow. Turning to surgical correction, the authors state that it is easier to modify an over-narrow angle, than one that is too wide. The authors show the single surgical techniques adopted for the correction of the angle, emphasizing the personal method applied to the overwide angle.

Female↗
PubMedDate not supplied

Personal approach to surgical correction of the extremely hypoplastic tuberous breast.

A surgical method for treatment of the extremely hypoplastic tuberous breast is described. It is based on turning differently shaped glandular flaps to correct the deformity, followed by insertion of a prosthesis, and, where necessary, correction of areola size and position and adjustment of the skin of the inferior pole. The results so far have afforded total and recurrence-free aesthetic correction of the usual deformities. The underlying aim of the operation is to transform a hypoplastic tuberous breast into a simple hypoplasia without discarding gland tissue which can be used to thicken the most deficient mammary area.

Breast↗
PubMedDate not supplied

Our "idèes fixes" in rhinoplasty: the naso-frontal angle and the alar lateral crus.

An examination of the naso-frontal angle shows that a cranial or caudal shift in position affects the dorsum length. The fundamental aspect characterizing the naso-frontal angle is its width: it may be normal, too wide, or too narrow. It's easier to modify a too-narrow angle than a too-wide one. We show surgical techniques, emphasizing their method applied to the over-wide angle. The second "idèe fixe" is the morphology of the alar lateral crus. Every variety of this structure has a peculiar property of shape and relationship with other elements that predetermines the therapeutic action. Diagrams and photographs are shown to describe the surgical techniques and the clinical results. There is also a demonstration of the method for alar lateral crus resection, which we call "the long keel shape," since it resembles the shape of a sailboat keel.

Esthetics↗
PubMedDate not supplied

Alar lateral crus in nasal tip surgery.

The authors consider the morphology of alar lateral crus as a means of classification. Every variety of lateral crus has a peculiar property of shape and relationship with other elements that determines the course of therapy. Diagrams for explication, descriptions of surgical techniques, and clinical results are included here.

Adult↗
PubMedDate not supplied

Primary reconstruction of the ala nasi in cleft Lip.

Displacement of the lateral crus of the alar cartilage of the nose in cleft lip is demonstrable in diagrams showing the pathological anatomy of this deformity. An account is given of our method used for several years, whereby the lateral limb is returned to a more natural position, alar convexity is restored, and the angle between the limbs is corrected. Two flaps taken from the inside surface of the nostril are alternated. The caudal one is a full-thickness flap composed of vestibular skin, while the cranial flap comprises the cartilage and the vestibular mucosa; the lateral limb is left attached to the mucosa. Alternation does not require any interruption of cartilage continuity, so there is no risk of surgical damage to the perichondrium and cartilage in young subjects. The two limbs (particularly the lateral one) are positioned in such a way that their normal growth can be expected, as shown by the aesthetic results on follow-up after a period of many years. This method is a primary reconstruction technique of the ala nasi, applied at the same time as the lip repair and compatible with current methods.

Cleft Lip↗