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Biomedical subjects

E N Beckman

Publications and source records attributed to E N Beckman.

At least 19 recordsLinked to original sources
PubMed1993

Spontaneous rupture of splenic hamartoma.

Hamartoma of the spleen is a rare benign tumor. Only one spontaneously ruptured splenic hamartoma has been reported that presented with an acute surgical abdomen. A second case of a ruptured hamartoma of the spleen is illustrated; however, this case is unique in that it presented as a nonsurgical abdomen. This case stresses the importance of serial physical examinations of the patient and appropriate diagnostic studies in correctly determining the diagnosis when preliminary findings are inconclusive. Surgeons should include splenic hamartomas in the differential diagnoses of splenic defects seen on radiologic studies or splenic masses palpated during abdominal exploration.

Female↗
PubMed1991

Neuromuscular hamartoma (benign "triton" tumor) of the brachial plexus. Case report.

Neuromuscular hamartoma (choristoma) or benign "triton" tumor is a very rare peripheral-nerve tumor composed of mature nerve fibers and well-differentiated striated muscle fibers. Only seven cases have been reported in the literature. A new case of this rare entity is described in a 36-year-old white woman with a recurrent left supraclavicular mass in the brachial plexus area. Unlike the previous cases, this patient had continued to have proliferation of her tumor since childhood, requiring total resection in adulthood. It is concluded that total resection of these tumors should be attempted at initial diagnosis. The histogenesis of these tumors remains unclear. They may represent proliferation of neuroectodermal-derived or limb mesodermal tissue in the elements of a peripheral nerve.

Adult↗
PubMed1990

Normal reticulin level in iliac bone marrow.

While the level of marrow reticulin may be a factor that is used when the presence of a hematologic disorder is being considered, to our knowledge no study has graded the amount of reticulin present in normal iliac bone marrow. Grading reticulin stains of bone biopsy specimens from 100 hematologically normal patients documented that the normal amount of reticulin in the marrow is low. Twenty-seven percent of the patients had marrow reticulin grade 0 using the Bauermeister scale, 42% had grade N, 27% had grade 1, and 4% had grade 2; no patient had a Bauermeister grade 3 or 4 reticulin level. Knowledge of the normal range of reticulin is essential when the reticulin level is used as a factor in evaluating the possibility of a hematologic disorder.

Adolescent↗
PubMed1989

Pulmonary dirofilariasis. The largest single-institution experience.

Pulmonary dirofilariasis caused by Dirofilaria immitis, the dog heartworm, is a rarely reported pulmonary lesion. It appears as a solitary pulmonary nodule, and the diagnosis is not established until thoracotomy and subsequent histologic examination of the specimen are performed. Sporadic reports of pulmonary dirofilariasis in the United States total only 70 cases. The six resections of pulmonary dirofilariasis at the Ochsner Clinic represent the largest reported series of cases originating at a single institution. We present an overview of the pathogenesis of this disease, its clinical manifestations, pathologic and epidemiologic features, and geographic distribution. The prevalence of pulmonary dirofilariasis appears to be increasing; hence, thoracic surgeons and pathologists need to be alert to this cause of granulomatous pulmonary lesions.

Adult↗
PubMed1988

Synovial sarcoma with an overwhelming epithelial component.

A patient 20 years of age had a synovial sarcoma, 90% of which was composed of very well-developed epithelial elements identical to moderately well-differentiated adenocarcinoma. Awareness of this histopathologic variant is important in establishing the proper diagnosis and in indicating prognosis.

Adenocarcinoma↗
PubMed1987

Multicystic renal oncocytoma.

The usual gross appearance of a renal oncocytoma is that of a well-circumscribed homogeneous tan-brown tumor with no evidence of necrosis or hemorrhage, but with a central fibrous scar. We describe a case of renal oncocytoma with the unusual gross appearance of a cystic tumor. While cystic change has occasionally been mentioned in an oncocytoma to our knowledge, this degree of cyst formation has not previously been described.

Adenoma↗
PubMed1986

Plasma cell infiltrates in atherosclerotic abdominal aortic aneurysms.

Thirty-one of 156 abdominal aortic resection specimens containing atherosclerotic aneurysm wall had an inflammatory infiltrate with a prominent plasma cell component of the media or of plaque replacing the media. The specimens in general were not examples of the so-called "inflammatory variant" of atherosclerotic aneurysm. No association between the infiltrate and syphilis, collagen vascular disease, furosemide exposure, chronic aneurysm leakage, aneurysm diameter, or duration of symptoms was found. The plasmacytic inflammation may be part of an immune response to atherosclerosis.

Aorta, Abdominal↗
PubMed1985

The histopathology of Mycobacterium marinum synovitis.

Eight patients with culture-proven Mycobacterium marinum synovitis had synovial specimens with a remarkably similar histologic appearance. There was considerable synovial hyperplasia, and the synovium was thickened by a moderately intense lymphohistiocytic infiltrate, notably devoid of plasma cells. Fibrin covered some synovial surfaces. Giant cells were both of the Langerhans' and foreign body types. Granulomas were noncaseating but varied in frequency and degree of definition. Knowledge of this morphologic picture has proved to be useful in patient care.

Adult↗
PubMed1985

Endometriosis of the prostate.

Endometriosis occurred within the prostate of a 78-year-old man after a long course of estrogen therapy. The presence of endometrial tissue in the region of the urethral crest has potential histogenic and therapeutic implications for some of the neoplasms that arise in this area.

Aged↗
PubMed1984

A potentially brighter prognosis for colon carcinoma in the third and fourth decades.

In contrast to earlier studies that suggested that colon carcinoma is unusually lethal in the young, 69 patients, ages 20 to 39 years, had a relatively good prognosis. Fifty-nine percent lived over 5 years after diagnosis, and 51% were cured. Furthermore, 67% were cured if they did not have distant spread of the carcinoma at the time of the initial operation. Neither age, sex, tumor size, location, mere presence of lymph node metastases, depth of tumor invasion, nor predisposing disease of the colon was a strong prognostic factor. Metastases to six or more lymph nodes and distant spread of the tumor at the time of initial surgery were ominous findings. Mucinous carcinoma was relatively frequent (28%) and was also an ominous feature (only 5 of 20 patients cured as opposed to 26 of 43 with classical adenocarcinoma).

Adenocarcinoma↗
PubMed1984

Persistent renal blastema in an adult.

To the authors' knowledge, this is the first reported case of any form of nephroblastomatosis occurring in an adult. Such a lesion is the presumed precursor of the rare Wilms' tumors that arise in adults.

Age Factors↗
PubMed1983

Renal cell carcinoma: the Ochsner Medical Institution experience (1945-1978).

We reviewed 161 patients operated upon for renal cell carcinoma between 1945 and 1978. Life table and survival analyses were computed to compare the effects of stage, tumor differentiation, cell type, surgical technique, renal vein involvement and sex on the years of survival. Patients with stage I and well differentiated tumors had the best prognosis. All patients surviving 10 years or more had well differentiated tumors. The type of nephrectomy did not affect survival and lymphadenectomy was only of value in staging the disease. The stage and differentiation of the tumor were more important to outcome than choice of therapy.

Adenocarcinoma↗
PubMed1983

Renal oncocytoma and its congeners.

Although the morphologic criteria for separating renal oncocytomas from renal carcinomas with overlapping features are not established completely, the distinction is crucial because of the marked difference in prognosis. Of the 247 renal carcinomas observed at our hospital since 1947, six had sufficient morphologic features of oncocytoma to pose potential difficulty in diagnosis. We term this group the "congeners of renal oncocytoma." Both the congeners and our 10 oncocytomas were well-circumscribed tumors, varied considerably in size, and were composed of cells with granular, pink-red cytoplasm. The congeners lacked the diffuse organoid packeting of cells, characteristic of oncocytoma. Additional features that helped separate individual congeners from oncocytomas included yellow-tan rather than brown-red gross color, necrosis, pleomorphism, ballooned cytoplasm, or clear cells. Our studies indicate that some renal carcinomas have fields identical to oncocytoma, and frozen section, needle biopsy, or aspiration cytology from such an area could lead to a misdiagnosis.

Adenoma↗
PubMed1983

Diagnostic use of CFU-E formation from peripheral blood in polycythemia vera.

Peripheral blood mononuclear cells from five patients with polycythemia vera (P. vera) and three with other polycythemias were cultured in a methylcellulose system. Colony-forming unit-erythroid (CFU-E) colonies appeared after seven days in the absence of added erythropoietin (Ep) in all P. vera cultures. A pattern of growth similar to the one seen for P. vera patients occurred in the culture from a patient in whom that disease was suspected. In the cultures from two of the patients with other polycythemias, erythroid colonies did not appear even in the presence of Ep. These findings emphasize the potential value of culturing peripheral blood for CFU-E colonies in diagnosing polycythemia vera.

Adult↗