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Biomedical subjects

E N Coomes

Publications and source records attributed to E N Coomes.

10 recordsLinked to original sources

Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthritis.

Benorylate and ibuprofen appear to be useful drugs for pain relief in rheumatoid arthritis but benorylate would appear to have a slightly better effect on the pain score and it improved the grip strength more than the moderate doses of ibuprofen. It could be a most useful drug when gastric problems limit the dose of aspirin or of other analgesics.

Arthritis, Rheumatoid

An assessment of penicillamine therapy in rheumatoid arthritis and the influence of previous gold therapy.

One hundred and fourteen patients with rheumatoid arthritis who had received treatment with penicillamine are reviewed. Side effects occurred in 50 patients. Sixty patients were considered to be improved with the drug. Low and high maintenance regimes were compared. There was no significant difference in the incidence of side effects or clinical improvement. Previous gold therapy did not influence the therapeutic response or total incidence of side effects observed with penicillamine. Rashes were, however, more common if patients had previously had treatment with gold.

Arthritis, Rheumatoid