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Biomedical subjects

E N Danilov

Publications and source records attributed to E N Danilov.

At least 19 recordsLinked to original sources

[Oxygen transport function of the blood in acute disorders of gas metabolism and of the acid-base state].

The oxygen-transport function of blood in hyperoxia and acute disturbances of the acid-alkali condition was studied in "oxygenator--desoxygenator" as a model. It has been established that in acidosis there occurs decreased intensity of glycolysis in erythrocytes, accumulation of 2,3 diphosphoglyceric acid which decreases affinity of hemoglobin for oxygen. It does not occur in alcalosis.

Acid-Base Imbalance↗

[Participation of the lungs in carbohydrate and lipid metabolism].

The utilization of glucose, NFA, triglycerides, cholesterol and alpha-lipoprotein cholesterol as well as the production of lactic acid were studied at different pH levels on the model of isolated lungs of the dog perfused in a special chamber maintaining the conditions close to physiological. The data obtained may be used for the assessment of lung metabolism under these conditions.

Animals↗

[Use of a membrane oxygenator for correcting acute, experimental respiratory insufficiency].

A model of acute respiratory insufficiency ARI was created in the experiments on 16 dogs by means of a valvular device furnishing a free inhalation and a limited expiration. The diaphragmatic oxigenator devised in VNIIP with an armoured diaphragm of "Sigma"--type was switched on at the height of ARI. 3 hours' perfusion corrected successfully the manifestation of hypercapnic hypoxia. The pulmonary function restored after the experiment.

Acute Disease↗

[Registration of the dynamics of acute pulmonary edema development by means of rheoplethysmography].

The dynamics of acute lung edema development caused by injection of oleic acid into the right heart chambers was traced experimentally on dogs by means of impedance plethysmography. The most of information was collected with the help of electrodes applied to the chest. The development of acute lung edema was followed by decrease of the impedance respiratory undulations and by changes in their characteristics.

Acute Disease↗

[Measurement of thoracic complex electrical resistance (impedance)].

Experimental grounds for using clinically the chest impedence recording are presented. The method allows recording of ventilatory and hemodynamic parameters mainly in the minor circulatory circuit under conditions of surgery on thoracic organs and postoperatively, as well.

Animals↗