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Biomedical subjects

E N Denisov

Publications and source records attributed to E N Denisov.

14 recordsLinked to original sources
PubMed1986

[Results of the clinical use of 75Se-methionine in gastroenterology with different modes of administration].

Gamma-topography of the abdominal region and radiometry of duodenal aspirates were used for examination of 707 patients with different gastroenterological pathology using various modes of the administration of 75Se-methionine (intravenously, per os, into the duodenal and cecal lumens, intra-arterially in the celiac trunk and superior mesenteric artery). The RP administered intravenously was accumulated in health in the liver and pancreas. The drug fixation by the proximal part of the jejunum was also typical of chronic pancreatitis, the degree of fixation being well correlated with a period of disease. A jejunum image on gamma-topograms proved to be determined not by radioactivity of the jejunum in passage of labeled pancreatic juice but by extraction of the radionuclide from the blood by its wall. In transduodenal administration of the radionuclide its major part was rapidly absorbed and accumulated in the liver. At the same time a considerable part of the drug remained at the site of administration and retained there for several days. There was almost no absorption of the drug in the cecum and ascending colon. Like in the duodenum, the drug retained at the site of administration for a long time. Intestinal extravasal trophicity was assumed.

Administration, Oral↗
PubMedDate not supplied

[Pulmonary hemodynamics during different regimens of AMV in patients with severe craniocerebral trauma].

Investigation of pulmonary hemodynamics were carried out in 26 victims operated on for brain compression with intracranial (epi-, subdural, and intracerebral) hematomas in combination with severe contusions during different regimes of artificial ventilation of the lungs (VCV, VCV + PEEP, PCV). Intracranial pressure and cerebral perfusion pressure were evaluated. The results indicate that in patients with severe craniocerebral injury PCV decreased systolic pulmonary artery pressure, total pulmonary resistance, central venous pressure, intracranial pressure, increased cerebral perfusion pressure, and therefore the pressure cyclic mode is pathogenetically validated in this patient population.

Acute Disease↗
PubMedDate not supplied

[Status of cerebral perfusion pressure and cerebral oxygenation in the acute period after cranio-cerebral injury].

Sixty-one patients with severe craniocerebral injuries were examined on days 1-3 after the injury. Consciousness was no more than 8 points by the Glasgow Coma Scale. The patients were divided into 2 groups: 1) favorable outcomes and 2) unfavorable outcomes. Gaseous composition of arterial and venous blood was analyzed in all patients, intracranial pressure (ICP) and cerebral perfusion pressure (CPP) were measured, artificial ventilation of the lungs (AVL) and noninvasive monitoring of cerebral oxygenation (CO) were carried out. The results indicate that continuous monitoring of CPP and CO helps control the time course of cerebral blood flow, thus promoting early detection and effective treatment of cerebral ischemia in critical patients.

Blood Gas Analysis↗
PubMedDate not supplied

[An algorithm of respiratory management in the complex treatment and prevention of acute pulmonary lesions in patients with impairments of the central nervous system].

The authors elaborated an algorithm of respiratory management (RM) based on the correlation of RM parameters with the actual and proper thoracopulmonary compliance (C). The algorithm was tested on 42 patients with affections of the central nervous system (CNS) due to severe craniocerebral trauma, spinal trauma, cerebral stroke and multitrauma. Thirty-nine case-matching patients where in the control group--the routine RM algorithm was used for them. Mean pressure in the respiratory paths (Pmean, C, PaO2/FiO2 and rSO2 readings by the Glasgow coma scale, cerebral perfusion pressure, and consumption of sedatives, muscle relaxants and vasopressins as well as frequency rate of acute pulmonary lesions (APL) were registered. The RM algorithm provided for a more effective prevention and treatment of APL versus the routine RM--it cut, 3-fold, the remote APL. With the above RM algorithm, the need in sedatives, muscle relaxants and vasopressins went down from day 2. Positive trends in the neurological status as well as normalized rSO2 were observed earlier versus the controls. Finally, its use ensured a more favorable treatment outcome.

Adult↗