Life-threatening arrhythmias and intravenous cimetidine.
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Biomedical subjects
Publications and source records attributed to E N Fry.
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The action of orphenadrine when given towards the end of a general anaesthetic is described. It is shown to delay the need for postoperative analgesia and extend the analgesic action of papaveretum.
Sublingual buprenorphine (0.4 mg) and intramuscular papaveretum (20 mg) were compared in sixty patients after abdominal hysterectomy. Though slower in onset of effect the sublingual tablets proved effective for pain relief and appeared to have a longer duration of action. The only side-effects of note were nausea and vomiting which occurred after both treatments. Haloperidol was tried as a long acting antiemetic and appeared successful.
A technique of postoperative analgesia using continuous intravenous papaveretum with a dosage derived from previous intravenous titration is described. Hourly pain scores, pulse and respiration rates, and blood pressure readings were recorded. The patients were followed up until discharge from hospital. The nature and incidence of various complications were noted.
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A technique of general anaesthesia involving the use of propanidid, nitrous oxide, oxygen and halothane followed by a slow injection of suxamethonium and lignocaine is described. The technique decreased the increase in serum potassium concentration that follows the injection of suxamethonium and, it is suggested, possesses advantages over the existing practice of the injection of non-depolarizing neuromuscular blocking drugs before suxamethonium in an attempt to reduce the frequency of serious cardiac arrhythmia.
During operations for squint nodal rhythm and other more serious arrhythmias such as heart block and multifocal ventricular extrasystoles, as well as the oculocardiac reflex, are shown to occur more frequently in patients with brown or hazel eyes than in patients with blue or grey eyes.
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A technique of premiedication using oral diazepam and metoclopramide with a drink is described and shown to provide better sedation and less vomiting than pethidine and atropine given intramuscularly without a drink to a group of similar patients.
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