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Biomedical subjects

E N Gerasimova

Publications and source records attributed to E N Gerasimova.

At least 19 recordsLinked to original sources
PubMed1990

[Possible relationship between polyunsaturated fatty acids and signs of left ventricle hypertrophy].

In aborigines from the costal and continental areas of Chukotka who differ in dietary polyunsaturated fatty acid (PFA) n-3 intake, specific features of the composition of fatty acids in cell membranes were revealed in a model of erythrocytes: the costal inhabitants showed a higher proportion of PFA n-3 mainly through eicosapentaenic acid and lower proportion of major PFA n-6. With this, plasma lipoprotein lipids in whose composition the acids transported to the cell membranes displayed the similar regularities in changes in fatty acid composition. Only a far larger portion of eicosapentaenic acid in the cell membranes from the costal inhabitants than from the continental inhabitants was associated with greater mass of the left ventricular myocardium. It was concluded that transport of lipids containing high PFA n-3 in the composition of lipoproteins to the cell membranes caused an increase of the acids in them and, evidently, a change in physicochemical and, therefore, functional properties of cells.

Adult↗
PubMed1988

[Fatty acids of the omega-3 line in the erythrocytes of Chukchi with myocardial hypertrophy].

A study was made of the fatty acid composition of erythrocytes in the Chukchi aged 30 to 59 with myocardial hypertrophy and in controls. In erythrocytes of the Chukchi the percentage of polyunsaturated fatty acids of omega-3 series including eicosapentaenoic acid was increased (C 20:5), and the percentage of linoleic acid and arachidonic acid was decreased (C 18:2 and C 20:4, respectively) as compared to similar indices of erythrocytes in Muscovites. Myocardial hypertrophy was diagnosed in the Chukchi in whom the percentage C 20:5 in erythrocytes was higher and exceeded that in PL. It was assumed that changes in the fatty acid composition of cell membranes played certain part in disorder of their function and the development of myocardial hypertrophy in the Chukchi.

Adult↗
PubMed1988

[Changes in phospholipid composition of high density lipoproteins in children as a possible precursor of the development of ischemic heart disease].

The proportion of apoprotein-AI (apo-AI) phospholipids (PL) and HDLP phospholipid spectrum were determined in addition to principal coronary risk factors; cholesterol (CS), triglycerides (TG) and high-density lipoprotein (HDLP) CS, in high-risk children, whose parents had survived myocardial infarction at a young age, and also in children with vegetovascular dystonia and a control group. It is demonstrated that children with relatively low percentage of lecithin in HDLP, in the absence of changes in CS, TG, apo-B and apo-AI, and HDLP CS, could be found in all the examined groups, and were particularly numerous in the high-risk group. Correlations coefficients for the HDLP PL percentage in the father-child, mother-child and father-mother pairs were estimated, revealing a positive correlation with respect to lecithin in these pairs, an evidence of the contribution of the general familial environment to the variability of the parameter in question in the examined groups. Different correlations were demonstrated between lecithin/sphingomyelin and lecithin/kephalin ratios in boys and girls from the control and high-risk groups.

Adolescent↗
PubMed1986

[Transport of the fatty acids composing the phosphatidylcholines and sphingomyelins of the low- and very high-density lipoproteins in the blood plasma in myocardial hypertrophy].

A comparative analysis of the fatty acid composition of phosphatidylcholines (PC) and sphingomyelins (SP) of lipoproteins (LP) of low and very low density was performed in the blood plasma of Eskimos (indigenous population of the Chukot Peninsula) in myocardial hypertrophy and in the control group as well as in the control group of Muscovites. Some characteristic features of the fatty acid composition of low density LP PC and SP were revealed in Eskimos in myocardial hypertrophy. The role of changes in the transport of fatty acids of low density LP PC and SP of the blood plasma in the myocyte membrane liquidity as well as in the synthesis of biologically active prostacyclin revealed in myocardial hypertrophy was discussed.

Adult↗
PubMed1985

[Changes in the indices of plasma lipoprotein and apolipoprotein spectra in patients with myocardial infarct and unstable stenocardia over the course of a year's observation].

Over the period of one year the authors examined the changes in the parameters of the plasma spectrum of lipoproteins and apolipoproteins in 46 patients with acute macrofocal myocardial infarction and 35 patients with labile angina. In six cases variations in these parameters were studied in the course of unstable angina and in the post-infarction period. It was established that myocardial infarction induced specific alterations in the plasma lipoprotein system not only in the immediate post-infarction period but also at more long-term periods. Myocardial infarction causes deep and prolonged disorders in the apolipoprotein system which may contribute to the progression of atherosclerotic damage to the coronary arteries.

Adult↗
PubMed1984

[Serum apolipoproteins A-1 and B in young males with a history of myocardial infarction].

The content of the protein-lipid components of lipoproteins of individual classes was studied in 87 coronary heart disease patients surviving myocardial infarction under 40 years of age. All the patients lived in Sverdlovsk. The control group was made up of 49 age-matched males without any symptoms of CHD. CHD patients aged 30-39 years showed a number of differences as compared to healthy men; these included elevated plasma levels of cholesterol, triglycerides and low-density lipoprotein cholesterol as well as an increase in the apoprotein B levels and the apo-B/apo-A1 ratio. In a group of CHD patients aged 20-29 years enhanced plasma concentrations of apo-B and an increase in the apo-B/apo-A1 ratio, the latter approaching 1 were the only change in the lipoprotein system as against control.

Adult↗
PubMed1983

[Arterial pressure and concentrations of blood lipids in the populations of Moscow and Leningrad].

Epidemiological investigation of two randomized groups of men born in 1916-1935 (3908 men in Moscow, 3907 in Leningrad) has shown that in both populations there is a direct relationship between the arterial pressure (AP) and the level of total cholesterol (CS), triglycerides (TG) and cholesterol lipoproteids of high density (CS-LPHD) in blood plasma. A strong correlation between the level of the systolic arterial pressure (SAP) and age has been established. Age variations of the lipid levels were insignificant. The total CS, TG, SAP levels and the diastolic AP increase with the growth of the relative body weight, while the CS-LPHD level decreases. In the group engaged in manual labour the total CS and TG levels are simultaneously lowered and those of CS-LPHD and SAP elevated. There is a direct relationship between the level of CS-LPHD, AP and alcohol intake. Smoking somewhat lowers the level of CS-LPHD and AP. The direct relationship between AP and the level of CS-LPHD remains after complex analysis including all the factors studied.

Adult↗
PubMed1982

Flow cytofluorometric study of lipoprotein interactions with cultured endothelial cells.

Accumulation of rhodamine B isothyocyanate-conjugated low density lipoproteins (R-LDL) in cultured endothelial cells from human umbilical cord was studied with a fluorescence activated cell sorter. R-LDL uptake was blocked at 0 degrees C, inhibited by addition of excess of nonlabeled low density lipoprotein, high density lipoprotein-2 or high density lipoprotein-3. High density lipoprotein-2 was about twice as effective in inhibition of R-LDL uptake as high density lipoprotein-3. Endothelial cells that formed a contact-inhibited monolayer lost the ability to incorporate R-LDL via a receptor-mediated pathway. Using R-LDL, it was possible to distinguish cells with different levels of R-LDL incorporation.

Cell Separation↗
PubMed1979

[Total cholesterol, triglyceride and alpha-lipoprotein cholesterol levels in the blood of 40- to 59-year-old men in Moscow and Leningrad].

A population survey of 6.990 males 40--59 years of age living in Moscow and Leningrad was conducted to determine the level of lipids in blood plasma by means of automatic standard biochemical methods. Curves were built of the distribution of the concentration of total cholesterol, triglycerides and alpha-lipoprotein cholesterol, and the average content, the upper levels of the norm (and the lower level of the norm for alpha-lipoprotein cholesterol too) were determined from them. The average content of total cholesterol was 217 mg/100 ml, that of triglycerides 100 mg/100 ml, and that of alpha-lipoprotein cholesterol 50 mg/100 ml. The upper norm levels for total and alpha-lipoprotein cholesterol found by cutting off 10% of the higher values were 270 and 75 mg/100 ml, respectively; the upper norm level for triglycerides (cutting off 5% of the higher values) was 250 mg/100 ml. The lower norm level for alpha-lipoprotein cholesterol (cutting off 10% of the lower values) was 35 mg/100 ml.

Adult↗
PubMed1979

[High-density lipoprotein subfractions and sex hormones in the blood plasma of men 40 to 59].

Examination of 50 males aged from 40 to 59 years showed that an increase or decrease in the level of cholesterol of high-density lipoproteins (HDLP) occurs mostly at the expense of cholesterol of the HDLP2 subfraction. Changes in the concentration of sex hormones in the blood plasma are attended by a change in the number of HDLP2 particles, evidence of which was a change in the content of HDLP2 cholesterol and phospholipids with the level of HDLP3 cholesterol and phospholipids remaining unaltered. A higher content is attended by a rise in the level of HDLP2 cholesterol and HDLP2 phospholipids. A negative correlation between the level of estradiol and that of triglycerides in blood plasma (r=-0.61; p less than 0.01) and a positive correlation between the content of estradiol and the level of HDLP2 cholesterol and phospholipids (r=+0.34; p less than 0.05 and r=+0.37; p less than 0.05, respectively were revealed in males with estradiol concentration of 1--8 ng/dl. There was no correlation between the above-mentioned values when the concentration of estradiol in blood plasma was higher (8--16 ng/dl). In hypoalphalipoproteinemia and hypertriglyceridemia, the relation in very low density lipoproteins of apoprotein SH, which inhibits lipoprotein lipase, and apoprotein SP, which activates this enzyme, was higher than normal while the relation of these apoproteins in HDLP was lower.

Adult↗
PubMed1979

[Thrombocyte phospholipids in ischemic heart disease with a varying degree of coronary arteriosclerosis severity].

A significant increase of the relative phosphatidyl serine level, a decrease in the percentage of lipoleic and arachidonic acids, and an increase in the oleic acid level were revealed in blood platelet phospholipids of patients with ischemic heart disease and severe coronary atherosclerosis. In the entire group of patients with ischemic heart disease (with coronary atherosclerosis of various degree), these changes are less marked and only the decrease in the linoleic acid level as compared to that in healthy individuals is significant. It was established that besides these changes in the phospholipid structures, blood platelet aggregation increases when the severity of the atherosclerotic process in the coronary arteries becomes more pronounced.

Adult↗
PubMed1979

[Lipid peroxides and atherosclerosis. The enzymatic detoxication of lipid peroxides in the blood in ischemic heart disease due to coronary artery arteriosclerosis].

It was established that in blood of patients with ischemic heart disease due to atherosclerosis of the coronary arteries (the diagnosis was verified in selective coronaroangiography) the content of acylhydroperoxides grows while the activity of glutathione-peroxidase II decreases. In blood of patients with no damage to the coronary vessels (according to the results of angiography), glutathione-peroxidase II activity does not differ significantly from the values in the control group. The decrease of glutathione-peroxidase II activity was most marked in patients with ischemic heart disease and hypercholesterolemia. It is suggested that the increase in the peroxide content in blood of patients with ischemic heart disease may be due to the sharp decrease in the activity of glutathione-peroxidase II.

Adult↗
PubMed1978

[Content of testosterone and of different classes of lipoproteins in the blood plasma of men 40-59 years old].

The blood plasma of males aged from 40 to 59 (227 practically healthy individual and 48 persons suffering from ischemic heart disease) was tested for the content of testosterone, cholesterol, triglycerides, cholesterol of various classes of lipoproteins and the lipoprotein spectrum by electrophoresis in polyacrylamide gel. It was found that a change in the testosterone level in the blood plasma, even within the limits of physiological values, may affect the plasma lipoprotein spectrum: a decrease in the testosterone concentration is attended with an increase in the content of atherogenic (beta- and pre-beta-) pipoproteins and a decrease in the content of alpha-lipoproteins.

Adult↗