Biomedical subjects
Publications and source records attributed to E N Kovalev.
It has been established that some patients with organic lesions of the nervous system develop intensive immunological reaction to catecholamines. The presence in such patients of antibodies to adrenaline and noradrenaline is indicative of considerable disruption of catecholamine biotransformation.
Metabolic activity of the mononuclear phagocytic system (MPS) was studied in 65 patients with disseminated sclerosis (DS) and 65 control persons by determination of the test-substance biotransformation intensity. Sulfadimezine undergoing acetylation in MPS cells was chosen as a test-substance. Sulfadimezine was administered per os; both unchanged drug and its acetylated metabolite were detected in urine in 6 hours. Correlation between acetylated and non-acetylated sulfadimezine levels permitted dividing the examinees into "rapid" or "slow" acetylators (inactivators). Patients with DS belong mainly to slow acetylators since the test-substance in MPS cells of these patients is inactivated slowly. Correlation between "slow" and "rapid" acetylators in patients with DS was 5:1, that in the control group 2:1. A similar pattern was reported previously in patient with systemic lupus erythematosus. New approaches to the mechanisms of DS development based on MPS functions analysis are outlined.
The activity of N-acetyltransferase was investigated in chronic alcoholics by the intensity of sulfadimezine acetylation. The activity of the enzyme was shown to vary with the stage of the disease. As compared with control, patients with Stage II disease exhibited the predominance of "rapid" acetylators (60%) whilst a significant fall in the number of "rapid" acetylators (from 60% to 36%) was detected in Stage II disease.
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