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Biomedical subjects

E N Levina

Publications and source records attributed to E N Levina.

At least 19 recordsLinked to original sources
PubMed1987

Proteus dysbioses in patients with ulcerative colitis.

In patients with ulcerative colitis Proteus could be isolated from all the gastrointestinal portions studied: mouth cavity, stomach, small intestine, small intestinal mucous membrane, and mostly from faeces. In some patients with ulcerative colitis a decrease in membraneous hydrolysis of polysaccharides was noted. Severe Proteus dysbiosis was associated with a sharp decrease in absorption processes at the small intestinal mucous membrane. The Proteus strains obtained from the patients belonged mostly to 3 serogroups: OA, OB, OC. Studies in virulent properties of Proteus in experiments with white mice gave positive results in 96% cases. Enterotoxin could be found in no case. As the result of vaccinal therapy in most patients disappearance or decrease of signs of malabsorption, increase in weight, stool normalization, and better hematological indices was manifested.

Colitis, Ulcerative↗
PubMed1986

[Microecology of the gastrointestinal tract of chronic enteritis patients].

The results obtained in the simultaneous study of the microbiology of different sections of the gastrointestinal tract (the oral cavity, the stomach, the large and small intestines) in chronic enteritis patients, as well as in the study of biopsy mucosa samples from the small intestine of such patients, are presented. This method has been shown to give a complete picture indicating both the severity of dysbiotic disturbances in the patient and the degree of their spread in the alimentary canal, which should be taken into account in clinical practice for the determination of the severity of the disease, the rational course of treatment and the time of the discharge of the patient from the hospital.

Bacteria, Aerobic↗
PubMed1985

[Characteristics of the composition of the causative agents of different forms of suppurative inflammatory diseases and their antibiotic sensitivity].

Antibiotic sensitivity of 466 clinical strains of gram-positive and gram-negative microorganisms isolated from patients with different forms of pyoinflammatory diseases was studied. Most of the staphylococcal isolates were resistant to benzylpenicillin (74.3 per cent). The number of the isolates resistant to erythromycin amounted to 59.6 per cent. The respective figures for methicillin and dicloxacillin were 17.9 and 10.8 per cent. Staphylococci resistant to new aminoglycosides, fusidin and rifampicin were rare. It was shown that. P. aeruginosa preserved its sensitivity to the majority of the antipseudomonas antibiotics. Among Enterobacteriaceae the highest levels of antibiotic resistance were observed in Enterobacter, Citrobacter, Serratia and Klebsiella. Significant variation in the isolation frequency of different microbial species and in the proportion of gram-negative and gram-positive bacteria in the hospital departments was observed. It was noted that gram-negative causative agents predominated in the departments of chest and abdominal surgery, anesthesiology, intensive care and urology.

Anti-Bacterial Agents↗
PubMed1985

[Laboratory methods of controlling the effectiveness of antibacterial therapy].

The serum antibacterial activity (SAA) against causative agent isolated after the use of antibiotics was studied in 68 patients with pyoseptic diseases. The SAA ranged from 1:2 to 1:512 and depended on the antibiotic sensitivity of the causative agents. Antibiotic therapy was effective, when the SAA was equal to 1:8-1:512. With the use of monotherapy the adequacy of the regimens was controlled by the relation between the maximal blood level of the antibiotic and its MIC for the causative agent. The favourable clinical effect of the treatment with aminoglycosides and beta-lactams corresponded to the SAA exceeding 4.

Adolescent↗
PubMed1983

[Characteristics of nonspecific resistance in children with lung diseases due to opportunistic microflora].

Acute destructive pneumonia in children was found to be complicated by acute pleural empyema (APE) on days 3-21 of the disease. The time of the development of this complication depended on the state of the nonspecific resistance of the body: the greater was the degree of deficiency as manifested by cell-mediated and humoral immunity indices, the earlier developed APE. Staphylococci and Pseudomonas aeruginosa infected the pleural cavity of children under the conditions of essentially decreased phagocytic activity, phagocytic index, C'H50 and one of the classes of immunoglobulin. The reaction of the body to staphylococci and P. aeruginosa took its course after the type of primary or secondary immune response, depending on the time of infection.

Acute Disease↗
PubMed1981

[Antibiotic behavior of Ps. aeruginosa strains isolated from various types of clinical material].

Altogether 158 strains of P. aeruginosa isolated from the material of open and close cavities and blood of patients with bronchopulmonary diseases were studied. It was found that the majority of the virulent (92.6 per cent) and avirulent (70.3 per cent) cultures were characterized by multiple resistance to tetracycline, streptomycin, monomycin, kanamycin, levomycetin and polymyxin B with preserved sensitivity to gentamicin and carbenicillin. The source of the P. aeruginosa isolation had a significant influence on its relation to the effect of antibiotics: the highest number of the resistant cultures was isolated from the blood. No differences in the antibiotic effect on P. aeruginosa depending on the serotype were observed. No differences in the antibiotic effect on P. aeruginosa depending on the serotype were observed. Virulent cultures of P. aeruginosa typed with group agglutinating sera and isolated from the material of the open and close cavities were characterized by a higher resistance level to tetracycline, kanamycin, monomycin and levomycetin than the virulent not-typed strains.

Animals↗
PubMed1981

[Conditionally pathogenic microflora of the Enterobacteriaceae family of healthy young children and children with acute intestinal infections of unknown etiology].

The study of quantitative and species composition of intestinal microflora in infants with acute intestinal infection of unknown etiology and in normal infants maintained on mixed feeding has revealed that most often bacteria belonging to the genus Proteus are found. The main difference between these groups consists in the presence of bacteria belonging to the genus Klebsiella, as well as other opportunistic intestinal bacteria, in greater amounts in sick infants than in healthy ones; at the time sick infants show a decrease in bifido- and lactobacteria.

Acute Disease↗
PubMed1979

[Serotype characteristics of clinical strains of Pseudomonas aeruginosa].

A total of 348 P. aeroginosa strains isolated from patients with pulmonary and pleural diseases were studied, and 87% of the test showed the possibility of their serotyping with the use of group-specific agglutinating antisera. Serogroups II, III, IV were found to be prevalent among the strains isolated from patients with bronchopulmonary pathological states. Correlations between definite groups of P. aeroginosa in their sensitivity to antibiotics were established; thus, the cultures belonging the serogroups II, III, IV were found to be more sensitive to tetracycline annd chloramphenicol than the culture belonging to other serogroups.

Anti-Bacterial Agents↗
PubMed1979

[Pathogenicity of clinical strains of Pseudomonas aeruginosa].

The study of 208 Ps. aeruginosa clinical strains, introduced intraperitoneally into white mice, revealed the statistically significant prevalence of pathogenic cultures (87.5--100%). The pathogenic strains of Ps. aeruginosa were found to have statistically significant differences in their cultural and biochemical properties depending on the kind of clinical material: the strains isolated from blood formed mucoid colonies, the zones of hemolysis and thermolabile or thermostable alkaline phosphatase, and typing could be made in 100% of the isolated cultures; the strains isolated from material of closed cavities formed mucoid colonies and the zones of hemolysis; the pathogenic strains isolated from material of open cavities showed only a tendency towards greater activity in the formation of extracellular sline and greater capacity for the formation of clarification zones on yolk agar as compared with nonpathogenic cultures.

Animals↗
PubMed1979

[Gastrointestinal tract microflora in nonspecific ulcerative colitis].

The species and quantitative composition of the normal and conditionally pathogenic microflora of the stomach, the proximal portion of the small intestine, in material obtained by biopsy from the mucosa of this portion, and in feces was studied in 10 patients with non-specific ulcerative colitis. The study was made before and after treatment. Before treatment in most of the patients gastric juice and the proximal portion of the small intestine were found to be greatly contaminated with microflora commonly present in feces, and in fecal microflora sharp dysbiotic changes were observed. As a result of treatment the microflora was essentially normalized (with the exception of Proteus and bifidobacteria).

Actinomycetaceae↗
PubMed1977

[Antibiotic sensitivity and pyocin dependence of clinical strains of Ps. aeruginosa].

The effect of antibiotics on clinical strains of Ps. aeruginosa was analyzed. It shown that 92 per cent of the strains had multiple resistance to the most of the antibiotics used in the clinic. All the strains were sensitive to gentamicin and polymyxin. The apyocinogenic strains of Ps. aeruginosa were more sensitive to the effect of the antibiotics than the pyocinogenic ones.

Anti-Bacterial Agents↗