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E N Maloman

Publications and source records attributed to E N Maloman.

8 recordsLinked to original sources

[Surgical treatment of patients with ulcerative pyloroduodenal stenosis].

The article discusses the results of surgical treatment of 342 patients with ulcerative pyloroduodenal stenosis. Selective proximal vagotomy (SPV) and truncal vagotomy (TV) with various operations were conducted in 202 patients, resection of the stomach--in 149 patients. To preserve the pylorus in the presence of anatomical conditions the authors combined SPV with duodenoplasty or pyloroduodenolysis (25 patients). The immediate results were best after vagotomy (0.4% fatal outcomes). Among 140 patients who underwent resection 5 (3.6%) died. Postoperative gastrostasis was encountered most frequently after vagotomy in patients with decompensated stenosis (17%). Bearing in mind marked and stable (up to 3 years) inhibition of gastric bioelectric activity occurring, according to the results of electrogastrography, after SPV, the authors consider decompensated stenosis too be a contraindication for any type of vagotomy. In the late-term period current peptic ulcers were revealed after SPV in 6.2%, after TV in 6.1%, and after resection in 2% of cases. Intraoperative pH measurement is recommended to improve the late-term results after vagotomy; it reduced the incidence of recurrences to 1.6%.

Adult

[Effect of proteolytic enzymes on the antimicrobial activity of antibiotics].

The results of the studies on the effect of chemotripsin on the antimicrobial activity of monomycin against laboratory cultures, such as Staph. aureus 209 P, E. coli M38 and Streptococcus zymogenes and 20 clinical strains isolated from patients with purulent peritonitis are presented. The studies were performed with the method of two-fold serial dilutions. It was found that chemotripsin decreased 3.2.10-2.6.10(5) times the MIC (minimum inhibitory concentration) and the bactericidal concentration of monomycin. The presence of fibrin in the medium inhibited 4-128 times the antibacterial effect of monomycin. The potentiating effect of chemotripsin on monomycin could be explained by both a better "contact" of the antibiotic with the microbes and an direct increase in the antibiotic sensitivity of the microbial cells. Combination of monomycin with chemotripsin provided the use of decreased doses of the antibiotic. It is an effective means of overcoming the antibiotic resistance in pathogenic microbes.

Adolescent