PubMed Health⌕ Search

Biomedical subjects

E N Padeĭskaia

Publications and source records attributed to E N Padeĭskaia.

At least 19 recordsLinked to original sources
PubMed1994

[New achievements in the fluoroquinolone problem: possibilities of increasing activity and expansion of the spectrum of action].

Studies of antibacterial compounds and drugs belonging to the derivatives of 6-fluoroquinolones are reviewed. The structure-function dependencies, the introduction of additional fluorine atoms to the structure and the cycle substitutions at positions 5 and 8 are discussed from the viewpoint of the antibacterial activity increasing and the spectrum broadening. The data on the activity of new 6-fluoroquinolones against gram positive bacteria, including pneumococci, anaerobic organisms, mycobacteria, chlamydia, and mycoplasma are presented. Compounds belonging to 6-fluoroquinolones substituted at positions 2 and 3 are discussed. The activity of 6-fluoroquinolones and their nonfluorinated derivatives is compared in general.

Anti-Infective Agents↗
PubMed1993

[Effectiveness of the new quinolones, ciprofloxacin and pefloxacin in experimental plague].

Efficacy of ciprofloxacin and pefloxacin in plague infection was studies on albino mice by comparison with that of nalidixic acid. The mice were contaminated subcutaneously. The treatment with the drugs was started 6 or 24 hours after the contamination. The MICs of ciprofloxacin, pefloxacin and nalidixic acid were 0.01 to 0.02, 0.15 and 1.25 to 2.5 micrograms/ml respectively. By the ED50 ciprofloxacin proved to be the most efficient. Pefloxacin was 6 times less efficient and nalidixic acid was 100 times less efficient. The quinolones were shown to be highly efficient when administered at 48-hour intervals.

Animals↗
PubMed1991

[Chromosomal resistance of plague agent to quinolones].

The nature of increasing chromosomal resistance to quinolones was studied in a model of the plague microbe. Five virulent strains of the natural plague microbe (Y. pestis) were used in the experiment: 363 (1/1479), 231, 2385, 2442 and 2444. The one-stage procedure for isolation of the mutants was applied. It was shown that the frequency of the one-stage mutants resistant to oxalinic acid, pefloxacin and ciprofloxacin amounted to 10(-9)-10(-11) and was 2 to 3 orders of magnitude lower than that of the mutants resistant to nalidixic acid. Two types of the plague microbe mutants resistant to the quinolones were detected: those resistant to the quinolones to the generations (Nalr-phenotype) and those resistant to the representatives of the 3rd generation quinolones (Nals-phenotype). The quinolones were not efficient in the treatment of albino mice with experimental plague caused by the quinolone-resistant forms of the plague microbe.

Animals↗