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Biomedical subjects

E N Wardle

Publications and source records attributed to E N Wardle.

At least 73 records · Page 4Linked to original sources
PubMed1987

Kupffer cells and their function.

The intention of this review is to stress new information regarding the quite versatile functions of Kupffer cells. Although their main function is phagocytosis and defence of the liver against bacteria, endotoxaemia and viral infections, they also fulfil other important roles. They will phagocytose and partially degrade bacterial antigens before handing them on to the hepatocytes for excretion into the bile. They handle LDL lipoproteins, whilst the HDL proceed directly into the hepatocytes. They produce lymphokine mediators that direct protein synthesis by the hepatocytes. Also they normally produce prostaglandins that are cyto-protective for the hepatocytes. Conversely, if they are required to attack infected hepatocytes or cancer cells, then they switch to the production of leukotrienes. Thus they function as specialised macrophages, and it is not surprising that other "activated macrophages" have to be recruited into the liver to support them in inflammatory reactions.

Animals↗
PubMed1987

Interferon-gamma: actions and importance.

Interferon-gamma is an important immune modulator that activates macrophages and enhances their antigen-presenting ability, boosts cell-mediated immune responses and increases antibody formation. It also enhances host cell-mediated immunity against cancer cells and it can inhibit their growth directly.

Antibody Formation↗
PubMed1985

Guide to the prostaglandins.

The prostaglandins are concerned with the regulation of all cells and physiological systems of the body. This article is a guide to the structure and action of there important substances.

Animals↗