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Biomedical subjects

E Navas

Publications and source records attributed to E Navas.

79 records · Page 5Linked to original sources
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[Analysis of preoperative reserve criteria and intraoperative transfusion of blood derivatives at an anesthesiology and recovery service].

Three hundred and three patients undergoing elective surgery were studied prospectively. Patient data and results of serial blood cell counts were recorded before and after surgery and used to evaluate the criteria used to reserve and transfuse blood and blood products, as well as to assess the outcome of transfusions performed. Six hundred and ninety-nine units were reserved, indicating a reservation-to-transfusion ratio of 1.8. The most often cited reasons for reserving blood were surgical technique, nature of disease and prolonged surgery. A high number of reservations were called for from the ward by the surgeons themselves. A total of 180 patients were given transfusions, the main reason being the anesthesiologist's judgement that the Hb count was low (in 26% of cases). Transfusions because of slight bleeding during surgery and prolonged surgery gave rise to the highest Hb counts. The lowest post-transfusion Hb counts recorded occurred when the reason cited was presence of signs of anemia. We conclude that the ratio of reservations to transfusions in our study was acceptable, as were the reasons justifying reserves. There is an overall tendency to achieve excessively high Hb counts (10-11 g/dl) in the early postoperative period. The best criterion for performing transfusion is the presence of signs of anemia.

Anesthesia Department, Hospital↗
PubMedDate not supplied

[Electroencephalographic effects of subhypnotic doses of midazolam in healthy subjects and in brain disease patients].

The aim of this study was to analyze the electroencephalographic alterations produced by minimum doses of midazolam and look for a theoretic base for these changes in the benzodiazepinic receptor. To do so, the possible abnormal responses provoked by midazolam on the EEG of patients with ischemic cerebral infarctions were studied. Sub-hypnotic infusions of midazolam (0.15 mg kg/min) were administered prior to anesthetic induction in three groups of patients: control group, patients with tumoral cerebral pathology group, and ischemic cerebral infarctions group. In addition to the known modifications obtained in the patients of the control group, those presenting bioelectric activity alterations due to tumoral pathology did not show modifications. In the group of patients with ischemic infarctions, the intravenous perfusion of midazolam induced moderate increase in the localized theta and delta frequency and a lower representation of the beta rhythm which was also of lower amplitude. Midazolam is capable of making slow rhythms on the EEG, following it administration at low doses, in ischemic zones of the brain.

Adult↗
PubMedDate not supplied

[Tuberculosis of the otorhinolaryngologic region: laryngeal and extra-laryngeal forms].

BACKGROUND: The aim of the study was to assess all patients with ENT symptoms whose histologic and/or microbiologic diagnosis confirmed tuberculosis. METHODS: All the anatomopathologic studies performed in the ENT unit in the authors' hospital in which the presence of acid-alcohol resistant bacilli were observed. All cases of cervical adenitis were not included. RESULTS: Eighteen patients with the following localizations were studied: 14 laryngeal tuberculosis and 4 extra-laryngeal tuberculosis (2 oropharyngeal, 1 otic and 1 sinusal). In the laryngeal forms, all patients were male except for one, and all were smokers. The duration of the symptoms was greater than 3 months in all the cases. Unilateral cord involvement was most commonly found, and in 2 cases this was associated with carcinoma of the vocal cord. Twenty-nine percent did not present with coincident pulmonary tuberculosis. None of the extra-laryngeal forms showed pulmonary involvement. All the patients were women and only 1 was smoker, the symptomatology was greater than 3 months in all cases and all required biopsy for achieving diagnosis. The evolution with medical treatment was favorable in all cases. During the same time period, 2300 cases of pulmonary tuberculosis were diagnosed in the authors' hospital. CONCLUSIONS: Tuberculosis of the upper respiratory tract is infrequent. Pulmonary involvement is common, although in this series this was only found in 71% of all laryngeal forms. Diagnosis is difficult, except in cases of coinciding pulmonary involvement and usually requires surgery for biopsy. Response to medical treatment is usually good.

Adult↗
PubMedDate not supplied

[The study of cost effectiveness of breast cancer detection in Catalonia].

BACKGROUND: This study has researched the cost-effectiveness of Early Diagnosis of Breast Cancer in Catalonian women in the 50-64 age group. METHODS: The cost-effectiveness ratio was obtained by comparing the costs of a program for 100,000 women with results achieved. The program consisted of a twice yearly mammography on all of the women over a 10 year period. The study assumed a participation level of 70%, detection rate of 0.36%, 92% sensitivity and specificity of 94%. RESULTS: A cost-effectiveness ratio of 1,413.648 pesetas was determined per case of cancer detected. 705,489 per year of extended life and 783,982 per year of extended life adjusted according to quality. Cost-effectiveness of the test in the first year was 842,400 per case of cancer detected. 383,183 per year of extended life and 425,418 per year of extended life adjusted according to quality. CONCLUSION: The results of the study are consistent with those obtained by other evaluations and show that early diagnosis of breast cancer is associated with a favourable cost-effectiveness ratio.

Adult↗