Renal fibrosis, origin and possible interventions: a time for action.
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Animals↗
Biomedical subjects
E Nigel Wardle
Publications and source records attributed to E Nigel Wardle.
Cellular oxidative processes in relation to renal disease.
This article summarizes the biochemical processes that produce reactive oxygen species (ROS) and other mediators that account for 'oxidative stress'. Formation of ROS in signal transduction cascades is illustrated from studies of kidney cell systems. The pathophysiological implications for the nephrologist are then reviewed.
Antioxidants↗
Is IgA nephropathy induced by hyperproduction of interferon-alpha?
The frequent occurrence of tonsillitis or upper respiratory tract infections preceeding exacerbations of haematuria in IgA nephropathy (IgAN) suggests a relationship to the pathogenesis. Since it has been shown that release of type I interferon (IFN-alpha) can promote the release of BAFF which aids maturation of B lymphocytes, and IFN-alpha is released as part of innate immunity to pathogens of the upper respiratory tract, it is suggested than IFN-alpha may trigger the pathogenic process of IgAN. How cells in the tonsils contribute and whether Il-6 formation in the lungs also helps development of Th.2 lymphocytes are to be considered.
Animals↗
Fish oils and glomerulonephritis.
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Fish Oils↗
Lupus nephritis in the new millennium.
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Clinical Trials as Topic↗
Antagonism of nuclear factor kappa B.
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Glomerulonephritis↗
COX-2 inhibitors and risk of heart failure.
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Blood Pressure↗