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Biomedical subjects

E Novitski

Publications and source records attributed to E Novitski.

11 recordsLinked to original sources
PubMed1981

The entire compound autosomes of Drosophila melanogaster.

Three new unusual compound chromosomes have been synthesized in Drosophila melanogaster. They consist of two homologous autosomes joined together in the new order: right arm, left arm, centromere, left arm, right arm, for each of the two major autosomes, and one in which chromosomes 2 and 3 have been combined in the order: right arm of 2, left arm of 2, centromere, left arm of 3, right arm of 3. The attachments of the autosomal arms were accomplished by obtaining chromosome breaks at or very close to the ends of the left arms of the autosomes such that no essential chromosome material has been removed; the compounds derived from them are therefore referred to as entire compounds. These large chromosomes are recovered in progeny with frequencies lower than expectation partly because of zygote mortality associated with these chromosomes, and partly because of a failure of spermiogenesis.

Animals↗
PubMed1981

Terminal chromosome attachments.

Descriptions are presented of four cases of attachment of chromosome material at the ends of normal chromosomes in Drosophila. Since no material appears to be missing from the polytene chromosomes and there are no ill effects to the organism in morphology, viability, or fertility when the chromosome is made homozygous, it is argued that the attachment occurred without the loss of any essential genetic material and that, in all probability, the break at the end of the chromosome occurred within the telomere of the chromosome. These cases may serve as a parallel to cases of apparent terminal breakage and reunion in certain rearrangements in man.

Animals↗
PubMed1977

What chance did Mendel's experiments give him of noticing linkage?

The a priori probability of noticeable linkage among all conceivable experiments of the size reported by Mendel cannot reasonably be taken as greater than 24-36 per cent; and therefore, the frequently heard opinion that his chances of encountering linkage were high, approaching 99-4 per cent, appears to be mistaken.

Chromosomes↗
PubMed1975

Evidence for the single phase pairing theory of meiosis.

The segregation pattern of an attached X chromosome with several Y-autosome translocations conflicts with the expectations based on the distributive pairing hypothesis because the chromosomes segregating from the translocation configuration include both exchange and non-exchange chromosomes. The results of the second experiment involving three compound chromosomes go even further; they suggest that the essential association which determines the segregation of nonhomologous elements is in fact set up prior to the time of crossing over.

Animals↗