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Biomedical subjects

E Nunzi

Publications and source records attributed to E Nunzi.

At least 19 recordsLinked to original sources
PubMed1990

[Multibacillary atypical mycobacteriosis].

A case of atypical multibacillary mycobacteriosis is described. The differential diagnosis is discussed on the basis of clinical, microbiological and histopathological parameters.

Adolescent↗
PubMed1989

[Anti-nDNA antibodies in lupus erythematosus].

Using the ELISA technique we have tested anti-nDNA antibodies in 79 patients affected with Lupus Erythematosus. The same patients have previously been tested for anti-cardiolipin antibodies. According to the literature, cross inhibition ELISA tests show no cross reactions between these two auto-antibodies families. Patients with highest anti-nDNA antibodies show a production of polyclonal (IgG, IgM, IgA) antinuclear antibodies responsible for a homogeneous pattern detected by indirect immunofluorescence.

Adult↗
PubMed1989

Traumatic eosinophilic ulcer of the oral mucosa.

A typical case of eosinophilic ulcer of the tongue is described. It confirms the traumatic cause for this benign, self-healing lesion that may be misdiagnosed and clinically confused with squamous cell carcinoma. The short time that the lesion takes to heal is an important diagnostic clue in differentiating eosinophilic ulcer of the tongue from cancer, thus sparing the patient unnecessary surgery or radiation therapy. The histopathologic pattern is also diagnostic. We prefer to call this lesion traumatic ulcer of the oral mucosa.

Aged↗
PubMed1985

The speckled immunofluorescence of epidermal nuclei as an in vivo phenomenon.

The deposition of speckled-patterned immunoglobulins in epidermal nuclei has been investigated in seventeen patients with various diseases other than mixed connective tissue disease. The phenomenon was seen not only with low titres of circulating antinuclear antibodies of IgG and IgM classes, but even in their absence. The clinical significance of this finding remains obscure, but the common explanation, that it is a simple artifact, seems quite untenable.

Antibodies, Antinuclear↗
PubMed1985

Urticaria-like follicular mucinosis.

Two middle-aged men with a cyclic eruption of transient urticarial papules of the face are described. Deposits of mucinous material were observed in cycstic spaces in their hair follicles. In direct immunofluorescence cells bearing IgE and C1q were found scattered in the dermis and were identified as mast-cells. Both patients experienced some relief of their disease in summer.

Facial Dermatoses↗
PubMed1979

Antibodies eluted from lymphoid cell membrane. Occurrence in certain varieties of scleroderma.

By means of acid elution two antibodies could be removed successfully from the circulating lymphocytes of 11 patients with certain varieties of scleroderma. One was specifically directed against nuclear antigen(s) of endothelial cells (NEC) of the dermal blood vessels, and another against nuclear antigen(s) of epidermal basal cells (NBC) of the involved and uninvolved skin of the patients. In two cases of acroscleroderma, the eluates failed to react with either endothelial or basal cells of involved or uninvolved skin. In none of 20 healthy controls involved in this study could an antibody be eluted from the circulating lymphocytes. The aforementioned antibodies do not bind complement in vitro and do occur in the serum of four patients. Circulating antinuclear antibody (speckled type) was detectable in two cases of scleroderma.

Antibodies↗
PubMed1978

Buckley's syndrome.

An infant girl with chronic eczema, recurrent infections, elevated IgE and impaired neutrophil chemotaxis appeared to belong to the group of patients described by Buckley, Wray & Belmaker (1972). An hereditary influence is suggested by a similar defect found in the patient's mother. Levamisole improved the in vitro defect and the clinical picture.

Chemotaxis, Leukocyte↗
PubMed1978

Evaluation of the local antihistaminic activity of dimetindene maleate by a quantitative method.

The topical application of a 0.1% dimetindene maleate gel on the forearms of 11 subjects reduces the areas of both erythema and wheal produced by the intradermal injection of 0.025 mg of histamine hydrochloride to a statistically greater degree than 1% d-chlorpheniramine maleate cream (p less than 0.005 and p less than 0.0005, respectively). The quantitative method employed in this study has proved to be an excellent means for the evaluation of the antihistaminic activity of topical preparations.

Administration, Topical↗
PubMedDate not supplied

[Anti-cardiolipin antibodies in lupus erythematosus].

Anti-cardiolipin antibodies (ACA) were investigated in the serum of 79 patients with lupus erythematosus by means of ELISA method. 34 patients (43%) had ACA in their serum. 63.6% of the patients with ACA had 4 or more ARA criteria and 75% of them had malar rash. None of our patients had the "anti-cardiolipin antibodies syndrome" but three of them with thrombocytopenia had ACA.

Adult↗