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Biomedical subjects

E O Shcherbakova

Publications and source records attributed to E O Shcherbakova.

At least 19 recordsLinked to original sources
PubMed2005

[Infectious complications in using mofetil micofenolate in patients with renal allotransplant].

AIM: To study infectious complications in renal transplant recipients receiving mycophenolate mofetil (MMF) for prevention of acute transplant rejection or treatment of chronic allograft nephropathy (CAN). MATERIAL AND METHODS: A group of renal transplant recipients (n=47) receiving 1.0-2.0 g/day MMF with cyclosporine A (CsA) and steroids as maintaining immunosuppression was compared to a group (n=47) taking triple immunosuppressive therapy which included azathioprine (Aza). Separate group of patients (n=9) received MMF for treatment of CAN. In all groups etiology and incidence of infections were evaluated. RESULTS: During 2 years various posttransplant infections developed in 72.3% patients on MMF and 93.6% on Aza. The incidence of viral infections was 53.2% in MMF and 59.6% in Aza group, the incidence of bacterial infection--55.3 and 70.2%, respectively. Among 9 recipients with CAN the infections occurred in five. There were two cases of active tuberculosis in Aza group, one--in MMF group and one in patients with CAN. CONCLUSION: We suggest that MMF in the dose 1-2 g/day does not increase infection rates in renal transplant recipients comparing Aza.

Acute Disease↗
PubMed1989

[The significance of early dysfunction of the transplanted kidney].

The paper is concerned with the results of 39 transplantations of the kidney. All the patients received two basic immunosuppressants, namely prednisolone in a dose of 30 mg/day and Cy in a dose of 10-12 mg/kg a day. Within 6 to 11 months, the recipients' survival amounted to 82.5%, that of the organs to 84.5%. In 63.1% of the patients, immediate function of the transplant could be observed. It has been demonstrated that delayed function of the transplant was conjugated with reduction of the survival of the organs and recipients as well as with decrease of the quality of transplant functioning. Delayed function of the transplant might be determined not only by ischemic but also by immunologic injuries to the organ.

Adolescent↗
PubMed1986

[Risk factors and results in kidney transplantation].

The authors analyzed the results of 139 kidney transplantations in 115 patients with chronic renal failure depending on a degree of risk. The most frequent risk factors were poor compatibility, high arterial hypertension, myocardial and valvular lesions and retransplantation. As to the combination of various risk factors 4 types of risk were defined. It was proved that in the 4th type of risk kidney transplantation was inappropriate. In the 2nd and 3rd types of risk sparing immunodepression was indicated.

Graft Rejection↗
PubMed1978

[Treatment procedure with surgical patients with acute renal insufficiency].

The results of the treatment of 49 cases of surgical diseases complicated with acute renal insufficiency are presented. The lethality was 36.8%. The effectiveness of the treatment depends upon proper time and a radical character of a surgical intervention. Preoperative treatment includes an active hemodialysis aimed at the arrest of uremic intoxication. Cardiovascular insufficiency does not make a contraindication for hemodialysis.

Acute Kidney Injury↗