PubMed Health⌕ Search

Biomedical subjects

E O Yhap

Publications and source records attributed to E O Yhap.

6 recordsLinked to original sources
PubMed1987

Reproductive and teratogenic effects of nitrous oxide, isoflurane, and their combination in Sprague-Dawley rats.

The reproductive and teratogenic effects of nitrous oxide (N2O), isoflurane, and their combination were studied in 130 timed-pregnant rats. Rats were exposed to either air, 0.35% isoflurane (1/4 MAC), 50% N2O (a known teratogenic concentration), or 50% N2O plus 0.35% isoflurane for 24 h on day 8 of pregnancy. On day 20 of pregnancy, cesarean sections were performed; a total of 1268 offspring were delivered and immediately examined for external abnormalities. They were subsequently examined microscopically either for visceral or skeletal abnormalities. N2O caused significantly higher incidences of early and late resorptions, and major visceral malformations. The addition of isoflurane to N2O prevented the majority of these adverse effects. These results cast doubt on the methionine synthase inhibition theory of N2O teratogenicity.

Abnormalities, Drug-Induced↗
PubMed1981

Cardiovascular effects of and catecholamine responses to high dose fentanyl-O2 for induction of anesthesia in patients with ischemic coronary artery disease.

Cardiovascular effects of high dose fentanyl-O2 during induction of anesthesia for coronary artery bypass surgery were studied in 10 A.S.A. class III patients. All patients had normal left ventricular function at cardiac catheterization and had ejection fractions greater than or equal to 0.60. Cardiovascular profiles, obtained after the stepwise intravenous administration of 15, 30, and 50 microgram/kg of fentanyl and compared with base line values, showed statistically significant decreases in cardiac and left ventricular stroke work indices. Plasma samples were assayed radioenzymatically for norepinephrine, epinephrine, and dopamine. Plasma norepinephrine levels were elevated significantly after 15 microgram/kg, remained elevated after 30 microgram/kg, but after 50 microgram/kg declined toward base line values. Mixed venous oxygen content decreased significantly after 50 microgram/kg of fentanyl. From these data, it is concluded that although high dose fentanyl-O2 is suitable for induction of anesthesia in patients with ischemic coronary artery disease, it may be associated with decreasing left ventricular function at doses in excess of 30 microgram/kg. The decrease in mixed venous oxygen content excludes decreasing metabolic demands as a sole reason for decreases in cardiac and left ventricular stroke work indices. The catecholamine response observed suggests either a dose- or time-related effect of fentanyl or the "stress" of induction of anesthesia.

Blood Pressure↗
PubMed1975

Decreased oxygen uptake with stored blood in the isolated hindlimb.

Storage of red cells in acid-citrate-dextrose (ACD) solution for more than a week has been shown to cause a reduction in red cell 2,3-diphosphoglycerate (2,3-DPG), resulting in a decrease in the half-saturation pressure (P50) of stored blood, thus increasing hemoglobin-oxygen affinity and theoretically decreasing oxygen delivery to the tissues. A method to isolate and perfuse the hindlimb in a dog has been developed and used successfully to compare the difference of oxygen release between banked and fresh ACD blood. Ten dogs were perfused using canine blood collected in standard blood transfusion bags containing ACD and stored at 4 degrees C and fresh blood collected in a similar manner but used immediately. The total oxygen release in the limb during perfusion with fresh blood was significantly greater than during perfusion with stored blood.

Animals↗